RGD Reference Report - A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. - Rat Genome Database

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A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts.

Authors: Zheng, D  Golubovskaya, V  Kurenova, E  Wood, C  Massoll, NA  Ostrov, D  Cance, WG  Hochwald, SN 
Citation: Zheng D, etal., Mol Carcinog. 2010 Feb;49(2):200-9.
RGD ID: 2317640
Pubmed: PMID:19885860   (View Abstract at PubMed)
PMCID: PMC3136037   (View Article at PubMed Central)
DOI: DOI:10.1002/mc.20590   (Journal Full-text)

Deregulation of insulin-like growth factor-1 receptor (IGF-1R) and focal adhesion kinase (FAK) signaling pathways plays an important role in cancer cell proliferation and metastasis. In pancreatic cancer cells, the crosstalk and compensatory mechanisms between these two pathways reduce the efficacy of the treatments that target only one of the pathways. Ablation of IGF-1R signaling by siRNA showed minimal effects on the survival and growth of pancreatic cancer cells. An increased activity of FAK pathway was seen in these cells after IGF-1R knockdown. Further inhibition of FAK pathway using Y15 significantly decreased cell survival, adhesion, and promoted apoptosis. The combination of Y15 treatment and IGF-1R knockdown also showed significant antitumor effect in vivo. The current study demonstrates the importance of dual inhibition of both these signaling pathways as a novel strategy to decrease both in vitro and in vivo growth of human pancreatic cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic cancer  IMP 2317640 RGD 
pancreatic cancer  ISOIGF1R (Homo sapiens)2317640; 2317640 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1r  (insulin-like growth factor 1 receptor)

Genes (Mus musculus)
Igf1r  (insulin-like growth factor I receptor)

Genes (Homo sapiens)
IGF1R  (insulin like growth factor 1 receptor)


Additional Information