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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1raffects expressionEXP 6480464CTDZinc affects the expression of IGF1R mRNAPMID:16413754
Igf1rdecreases expressionEXP 6480464CTDZinc deficiency results in decreased expression of IGF1R mRNA; Zinc deficiency results in decreased expression of IGF1R proteinPMID:21893222
Igf1rincreases phosphorylationEXP 6480464CTDZinc results in increased phosphorylation of IGF1R proteinPMID:14644152
Igf1rdecreases expressionISOIGF1R (Homo sapiens)6480464CTDZinc results in decreased expression of IGF1R proteinPMID:19913001
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTDZinc promotes the reaction [IGF1 protein binds to IGF1R protein]; Zinc promotes the reaction [IGF2 protein binds to IGF1R protein]PMID:9648927
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