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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rdecreases expressionEXP 6480464CTDDihydrotestosterone results in decreased expression of IGF1R proteinPMID:10650946
Igf1rmultiple interactionsEXP 6480464CTDnilutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of IGF1R protein]PMID:10650946
Igf1rincreases expressionISOIGF1R (Homo sapiens)6480464CTDDihydrotestosterone results in increased expression of IGF1R mRNA; Dihydrotestosterone results in increased expression of IGF1R proteinPMID:18491370 PMID:29581250
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTDMasoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R mRNA]; Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R protein]PMID:18491370
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