Gene:	Hras ( Rattus norvegicus ) Harvey rat sarcoma virus oncogene
Description:	mutated in rats exposed to the carcinogen 2-amino-1-methyl-6phenylimidazo[4;5-b]pyridine (PhiP); may be involved in the pathogenesis of chemically induced mammary tumors
Synonyms:	HRAS1; c-H-ras; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog;  (details...)
ArrayIDs:	6055263; A_44_P191864; 5848305; M13011cds_at; 6634632; 5673927; A_44_P191862; 1371255_at; 6436634; 6281677; 6652423; 5730581; 6332574;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Hcar4 - Hepatocarcinoma resistance QTL 4
Curated Variants:	Eras-ps
primer pair:	635087
Homologs
Homo sapiens: HRAS     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Hras1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Hras RH 3.4 1 1437.21     Rat Celera Assembly 1 193930155 - 193934070     RGSC genome assembly v3.4 1 201385925 - 201389504     Cytogenetic 1 q41     genome assembly 3.1 1 201540000 - 201542640 Mus musculus Hras1 Mouse genome assembly build 36.1 7 148377247 - 148378839     Cytogenetic 7 7 F5 Homo sapiens HRAS human genome assembly 11 522242 - 525550     Human genome assembly build 36.2 11 522242 - 525550     Cytogenetic 11 p15.5   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology GTP binding,  protein binding,  nucleotide binding ...  (details...)
Biological Process	Note Reference decreases both expression levels and activities of dystrophin-glycoprotein complex (DGC) in muscle atrophy 625642 Gene Ontology endocytosis,  positive regulation of cell proliferation,  negative regulation of neuron apoptosis ...  (details...)
Cellular Component	Gene Ontology intracellular,  anchored to membrane,  plasma membrane ...  (details...)
Disease	Ontology Diabetic Retinopathy (details...)
Phenotype	Ontology abnormal retinal apoptosis (details...)
Behavior	Ontology Autistic Disorder (details...)
External Links
Databases	DATABASE ID SOURCE SMART: RAS IPI PROSITE: RAS IPI UNIPARC: UPI0000001251 IPI UNIPARC: UPI000013312F IPI UNIPARC: UPI0001B7C093 IPI KEGG Report: rno:293621 ENTREZGENE HomoloGene Group ID: 55890 ENTREZGENE Germonline: 2827 Pfam: Ras IPI KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04530 ENTREZGENE KEGG Pathway: 05216 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04540 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 04144 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 05219 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 05221 ENTREZGENE KEGG Pathway: 05218 ENTREZGENE KEGG Pathway: 04916 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04720 ENTREZGENE KEGG Pathway: 04730 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE InterPro: GTPase_Ras. IPI InterPro: Ras. IPI InterPro: Ras_Ras_related. IPI InterPro: Ras_small_GTPase. IPI InterPro: Small_GTP_bd. IPI InterPro: Ras_GTPase. IPI Ensembl Protein: ENSRNOP00000022363 IPI Ensembl Protein: ENSRNOP00000060317 IPI IPI: IPI00196529 IPI IPI: IPI00763926 IPI IPI: IPI00948872 IPI Entrez Gene: Hras ENTREZGENE IMAGE_CLONE: IMAGE:7380273 IMAGE-MGC_LOAD IMAGE_CLONE: IMAGE:7318824 IMAGE-MGC_LOAD MGC_CLONE: MGC:105810 IMAGE-MGC_LOAD MGC_CLONE: MGC:116273 IMAGE-MGC_LOAD UniProt: RASH_RAT IPI UniProt: Q4KLL6_RAT IPI UniProt: Q8CGQ3_RAT IPI UniProt: Q5RJJ8_RAT IPI Ensembl Genes: ENSRNOG00000016611 IPI RatMap: 34068 ENTREZGENE PANTHER: Ras_Ras_related IPI TIGRFAMs: small_GTP IPI PRINTS: RASTRNSFRMNG. IPI
Sequences	Nucleotide: CO567790 Get FASTA Search GEO Profiles Nucleotide: NM_001130441 Get FASTA Search GEO Profiles Nucleotide: BC086608 Get FASTA Search GEO Profiles Nucleotide: NM_001098241 Get FASTA Search GEO Profiles Nucleotide: BC099130 Get FASTA Search GEO Profiles Nucleotide: XM_001062236 Get FASTA Search GEO Profiles Nucleotide: M61016 Get FASTA Search GEO Profiles Nucleotide: XM_001061671 Get FASTA Search GEO Profiles Nucleotide: AC118351 Get FASTA Search GEO Profiles Nucleotide: AY157970 Get FASTA Search GEO Profiles Nucleotide: M13011 Get FASTA Search GEO Profiles Nucleotide: CH473953 Get FASTA Search GEO Profiles (View all 12 Nucleotide Accessions) Protein: EDM11988 Get FASTA Protein: AAN76327 Get FASTA Protein: AAA42009 Get FASTA Protein: NP_001123913 Get FASTA Protein: NP_001091711 Get FASTA Protein: AAH86608 Get FASTA Protein: XP_001062236 Get FASTA Protein: AAH99130 Get FASTA Protein: EDM11987 Get FASTA Protein: P20171 Get FASTA Protein: Q4KLL6 Get FASTA Protein: Q5RJJ8 Get FASTA Protein: Q8CGQ3 Get FASTA Protein: XP_001061671 Get FASTA (View all 14 Protein Accessions)
Clusters	UniGene: 102180 UniGene: 129785
References
Curated References	13 references in RGD related to Hras
Other References	26 other references at PubMed related to Hras
Database Information
RGD ID	2827
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 15-FEB-08: Hras Harvey rat sarcoma virus oncogene Hras Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 10-JUN-02: Hras Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog APPROVED Symbol and Name status set to approved 70586