Hras (HRas proto-oncogene, GTPase) - Rat Genome Database

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Gene: Hras (HRas proto-oncogene, GTPase) Rattus norvegicus
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Symbol: Hras
Name: HRas proto-oncogene, GTPase
RGD ID: 2827
Description: Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and phospholipase C activator activity. Involved in several processes, including Ras protein signal transduction; positive regulation of DNA replication; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within insulin-like growth factor receptor signaling pathway and positive regulation of Ras protein signal transduction. Located in plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (S)-nicotine; 1,2-dichlorobenzene; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-H-ras; GTPase HRas; H-Ras-1; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma virus oncogene; HRAS1; p21ras; transforming protein p21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hcar4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,712,625 - 205,729,406 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1205,725,975 - 205,729,590 (-)EnsemblGRCr8
mRatBN7.21196,290,127 - 196,299,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,296,263 - 196,300,615 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1204,641,764 - 204,645,046 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,768,581 - 211,771,863 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,442,715 - 204,445,997 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,178,404 - 214,181,841 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,178,407 - 214,181,686 (-)Ensemblrn6Rnor6.0
Rnor_5.01221,095,943 - 221,099,362 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41201,385,705 - 201,388,987 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1193,930,281 - 193,933,583 (-)NCBICelera
RGSC_v3.11201,540,000 - 201,542,640 (-)NCBI
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
Alzheimer's disease  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cardiofaciocutaneous syndrome  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
Costello syndrome  (ISO,ISS)
Desbuquois dysplasia  (ISO)
diabetic retinopathy  (IDA)
Disease Progression  (ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IAGP,ISO)
Experimental Neoplasms  (ISO)
Follicular Thyroid Cancer  (ISO)
gastric adenocarcinoma  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO,ISS)
Hydrops Fetalis  (ISO)
large congenital melanocytic nevus  (ISO)
Leber congenital amaurosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
liver cancer  (ISO)
liver carcinoma  (IDA)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung squamous cell carcinoma  (ISO)
malignant astrocytoma  (ISS)
melanoma  (ISO)
Mouth Neoplasms  (IEP,ISO)
multiple myeloma  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neoplastic Processes  (ISO)
neuroblastoma  (ISO)
Noonan syndrome  (ISO)
obsessive-compulsive disorder  (ISO)
Ovarian Neoplasms  (ISO)
papillary renal cell carcinoma  (ISO)
papilloma  (ISO)
Penile Neoplasms  (ISO)
phobic disorder  (ISO)
pre-malignant neoplasm  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
RASopathy  (ISO)
Recurrence  (ISO)
seminoma  (ISO)
skin benign neoplasm  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
Splenic Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Trichilemmoma  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-Amino-2,4-dibromoanthraquinone  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3-aminobenzamide  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
ABT-100  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (ISO)
Azoxymethane  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[c]phenanthrene  (ISO)
Benzoyl peroxide  (ISO)
beryllium atom  (EXP)
beryllium dihydride  (EXP)
beryllium(0)  (EXP)
beta-lapachone  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
capecitabine  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzoylmethane  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erastin  (ISO)
escitalopram  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
farnesol  (ISO)
farnesyl diphosphate  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
GDP  (ISO)
geraniol  (ISO)
glafenine  (EXP)
gliotoxin  (ISO)
glucaric acid  (ISO)
glucose  (EXP)
glutathione  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
Goe 6976  (ISO)
GTP  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyl  (ISO)
iodoacetic acid  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoprenaline  (EXP)
isoprene  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
L-744832  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
limonene  (ISO)
lipopolysaccharide  (ISO)
lonafarnib  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
Maduramicin  (EXP)
malathion  (ISO)
manumycin A  (EXP,ISO)
MeIQ  (ISO)
MeIQx  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP)
Mezerein  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (EXP)
myricetin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-hydroxy-4-aminobiphenyl  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naringin  (EXP,ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitrofurazone  (EXP)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
plutonium atom  (EXP)
progesterone  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
Risedronate sodium  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
Siomycin A  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
SU6656  (ISO)
sulfur dioxide  (EXP)
superoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
Tetranitromethane  (EXP)
thapsigargin  (ISO)
theaflavin  (ISO)
thiram  (ISO)
thyroxine  (EXP)
tipifarnib  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (EXP)
triciribine  (ISO)
trimethyltin  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vinyl carbamate  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
cellular response to gamma radiation  (ISO)
cellular senescence  (IBA,IEP,ISO)
defense response to protozoan  (ISO)
endocytosis  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (IDA)
intrinsic apoptotic signaling pathway  (ISO)
liver development  (IEP)
myelination  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (ISO)
oncogene-induced cell senescence  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of DNA replication  (IMP)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP,ISO)
positive regulation of gene expression  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of miRNA metabolic process  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of Ras protein signal transduction  (IMP)
positive regulation of ruffle assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of wound healing  (ISO)
Ras protein signal transduction  (IBA,IEA,IMP,ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cell cycle  (ISO)
regulation of cell population proliferation  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to isolation stress  (IEP)
Schwann cell development  (ISO)
signal transduction  (IEA)
small GTPase-mediated signal transduction  (ISO)
T cell receptor signaling pathway  (ISO)
T-helper 1 type immune response  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
adenosine signaling pathway  (ISO)
B cell receptor signaling pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
endocytosis pathway   (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
erythropoietin signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
hepatitis C pathway   (IEA)
insulin signaling pathway  (IEA,ISO)
insulin-like growth factor signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
long term depression  (IEA)
long term potentiation  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (ISO)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
syndecan signaling pathway  (ISO)
T cell receptor signaling pathway   (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (ISO)
thyroid cancer pathway  (IEA)
urinary bladder cancer pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Germline mutations in HRAS proto-oncogene cause Costello syndrome. Aoki Y, etal., Nat Genet. 2005 Oct;37(10):1038-40. Epub 2005 Sep 18.
2. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Auer KL, etal., Mol Biol Cell. 1998 Mar;9(3):561-73.
3. c-H-ras and c-K-ras gene hypomethylation in the livers and hepatomas of rats fed methyl-deficient, amino acid-defined diets. Bhave MR, etal., Carcinogenesis. 1988 Mar;9(3):343-8. doi: 10.1093/carcin/9.3.343.
4. Predicting Recurrence and Progression of Noninvasive Papillary Bladder Cancer at Initial Presentation Based on Quantitative Gene Expression Profiles. Birkhahn M, etal., Eur Urol. 2009 Sep 9.
5. Activation of RAS family genes in urothelial carcinoma. Boulalas I, etal., J Urol. 2009 May;181(5):2312-9. Epub 2009 Mar 19.
6. Transforming function of proto-ras genes depends on heterologous promoters and is enhanced by specific point mutations. Chakraborty AK, etal., Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2217-21.
7. Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide. Cho YM, etal., J Toxicol Sci. 2009 Oct;34(4):407-12.
8. Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy. Chockalingam PS, etal., Am J Physiol Cell Physiol 2002 Aug;283(2):C500-11.
9. Studies of the c-Harvey-Ras gene in psychiatric disorders. Comings DE, etal., Psychiatry Res. 1996 Jun 26;63(1):25-32.
10. High mutation frequency in ras genes of skin tumors isolated from DNA repair deficient xeroderma pigmentosum patients. Daya-Grosjean L, etal., Cancer Res. 1993 Apr 1;53(7):1625-9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. Goriely A, etal., Nat Genet. 2009 Nov;41(11):1247-52. Epub 2009 Oct 25.
14. TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study. Gormally E, etal., Cancer Res. 2006 Jul 1;66(13):6871-6.
15. An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences. Gripp KW, etal., Am J Med Genet A. 2015 Sep;167A(9):2085-97. doi: 10.1002/ajmg.a.37128. Epub 2015 Apr 25.
16. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Groesser L, etal., Nat Genet. 2012 Jun 10;44(7):783-7. doi: 10.1038/ng.2316.
17. Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism. Herault J, etal., Psychiatry Res 1993 Mar;46(3):261-7.
18. Frequency of Ha-ras-1 gene mutations inversely correlated with furan dose in mouse liver tumors. Johansson E, etal., Mol Carcinog. 1997 Apr;18(4):199-205.
19. Investigation of oncogenic cooperation in simple liver-specific transgenic mouse models using noninvasive in vivo imaging. Ju HL, etal., PLoS One. 2013;8(3):e59869. doi: 10.1371/journal.pone.0059869. Epub 2013 Mar 28.
20. Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy. Kanwar M and Kowluru RA, Microvasc Res. 2008 Nov;76(3):189-93. Epub 2008 Apr 25.
21. DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. Kelly PA and Rahmani Z, Mol Biol Cell. 2005 Aug;16(8):3562-73. Epub 2005 May 25.
22. Mouse induced glioma-initiating cell models and therapeutic targets. Kondo T, Anticancer Agents Med Chem. 2010 Jul;10(6):471-80.
23. Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats. Kowluru RA, etal., Diabetes 2004 Mar;53(3):775-83.
24. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. Modulation of apoptosis, tumorigenesity and metastatic potential with antisense H-ras oligodeoxynucleotides in a high metastatic tumor model of hepatoma: LCI-D20. Liao Y, etal., Hepatogastroenterology. 2000 Mar-Apr;47(32):365-70.
26. Activation of ras oncogene in livers with cirrhosis. Liu P, etal., J Hepatol. 1994 Dec;21(6):1103-8.
27. Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a. Luth HJ, etal., Brain Res. 2000 Jan 3;852(1):45-55.
28. Down-regulation of K-ras and H-ras in human brain gliomas. Lymbouridou R, etal., Eur J Cancer. 2009 May;45(7):1294-303. doi: 10.1016/j.ejca.2008.12.028. Epub 2009 Jan 27.
29. Transcriptional activation of H- and N-ras oncogenes in human cervical cancer. Mammas IN, etal., Gynecol Oncol. 2004 Mar;92(3):941-8.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence. Min LJ, etal., Cardiovasc Res. 2007 Dec 1;76(3):506-16. Epub 2007 Jul 24.
32. Expression of ras p21 in the stromal cells of human neoplastic endometrium. Miturski R, etal., Eur J Gynaecol Oncol. 1998;19(3):308-11.
33. Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide. Naoi K, etal., Oncol Rep. 2010 Feb;23(2):337-44.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Increased expression of c-myc and c-Ha-ras in dichloroacetate and trichloroacetate-induced liver tumors in B6C3F1 mice. Nelson MA, etal., Toxicology. 1990 Oct;64(1):47-57.
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. [Immunohistochemical detection of p21ras, c-myc and p53 oncoproteins in hepatocellular carcinoma and in non-neoplastic liver tissue]. Pannain VL, etal., Arq Gastroenterol. 2004 Oct-Dec;41(4):225-8. doi: /S0004-28032004000400005. Epub 2005 Mar 29.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. GOA pipeline RGD automated data pipeline
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. MEK1/2 dual-specificity protein kinases: Structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
45. Distinct functions of H-Ras and K-Ras in proliferation and survival of primary hepatocytes due to selective activation of ERK and PI3K. Rosseland CM, etal., J Cell Physiol. 2008 Jun;215(3):818-26.
46. H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis. Roy S, etal., Mol Cell Biol 2002 Jul;22(14):5128-40.
47. Farnesyl transferase inhibitors induce neuroprotection by inhibiting Ha-Ras signalling pathway. Ruocco A, etal., Eur J Neurosci. 2007 Dec;26(11):3261-6. Epub 2007 Nov 14.
48. Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways. Sasaoka T, etal., Endocrinology. 1996 Oct;137(10):4427-34. doi: 10.1210/endo.137.10.8828504.
49. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. Shu FJ, etal., Cell Signal. 2010 Mar;22(3):366-76. doi: 10.1016/j.cellsig.2009.10.005. Epub .
50. H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity. Thornton C, etal., J Biol Chem. 2003 Jun 27;278(26):23823-9. Epub 2003 Apr 14.
51. Frequent activating HRAS mutations in trichilemmoma. Tsai JH, etal., Br J Dermatol. 2014 Nov;171(5):1073-7. doi: 10.1111/bjd.13143. Epub 2014 Sep 30.
52. Susceptibility of experimental autoimmune hepatitis in transgenic mice overexpressing the c-H-ras gene. Tsunematsu S, etal., J Gastroenterol Hepatol. 1997 Apr;12(4):319-24.
53. Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation. Vairaktaris E, etal., Histol Histopathol. 2009 May;24(5):531-9.
54. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
55. Recurring HRAS mutation G12S in Dutch patients with Costello syndrome. van Steensel MA, etal., Exp Dermatol. 2006 Sep;15(9):731-4.
56. ras gene mutations in human endometrial carcinoma. Varras MN, etal., Oncology. 1996 Nov-Dec;53(6):505-10. doi: 10.1159/000227627.
57. MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. Wang XF, etal., J Cancer Res Clin Oncol. 2012 Apr;138(4):573-84. doi: 10.1007/s00432-011-1114-x. Epub 2011 Dec 30.
58. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. Willard FS, etal., PLoS One. 2009;4(3):e4884. doi: 10.1371/journal.pone.0004884. Epub 2009 Mar 25.
59. Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis. Yaswen P, etal., Mol Cell Biol. 1985 Apr;5(4):780-6. doi: 10.1128/mcb.5.4.780.
60. H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer. Yu M and Snyderwine EG, Carcinogenesis 2002 Dec;23(12):2123-8.
61. Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase. Zhuravliova E, etal., Behav Brain Res. 2009 Dec 28;205(2):377-83. Epub 2009 Jul 16.
Additional References at PubMed
PMID:3023901   PMID:8142349   PMID:8316835   PMID:9054499   PMID:9178006   PMID:9219684   PMID:9230043   PMID:9679960   PMID:9765203   PMID:10845775   PMID:11022048   PMID:11877426  
PMID:12202034   PMID:12427827   PMID:12446704   PMID:12477932   PMID:12824760   PMID:12878730   PMID:14500341   PMID:14712229   PMID:15037605   PMID:15572682   PMID:15831492   PMID:15837622  
PMID:16153441   PMID:16213212   PMID:16478791   PMID:16568090   PMID:16717102   PMID:16895916   PMID:16954213   PMID:17260967   PMID:17380122   PMID:17724343   PMID:18218323   PMID:18367547  
PMID:18408766   PMID:18454179   PMID:18556515   PMID:18604197   PMID:19966300   PMID:20154697   PMID:20603646   PMID:21357543   PMID:21444916   PMID:21968647   PMID:22065586   PMID:22829592  
PMID:23027131   PMID:23648844   PMID:24553818   PMID:25533468   PMID:25774517   PMID:26035971   PMID:26568031   PMID:27125250   PMID:28193718  


Genomics

Comparative Map Data
Hras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,712,625 - 205,729,406 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1205,725,975 - 205,729,590 (-)EnsemblGRCr8
mRatBN7.21196,290,127 - 196,299,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,296,263 - 196,300,615 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1204,641,764 - 204,645,046 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,768,581 - 211,771,863 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,442,715 - 204,445,997 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,178,404 - 214,181,841 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,178,407 - 214,181,686 (-)Ensemblrn6Rnor6.0
Rnor_5.01221,095,943 - 221,099,362 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41201,385,705 - 201,388,987 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1193,930,281 - 193,933,583 (-)NCBICelera
RGSC_v3.11201,540,000 - 201,542,640 (-)NCBI
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
HRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811532,242 - 535,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11532,242 - 537,343 (-)Ensemblhg38GRCh38
GRCh3711532,242 - 535,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611522,242 - 525,550 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411522,242 - 525,550NCBI
Celera11594,708 - 598,010 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11346,981 - 349,115 (-)NCBIHuRef
CHM1_111529,852 - 534,465 (-)NCBICHM1_1
T2T-CHM13v2.011579,238 - 582,554 (-)NCBIT2T-CHM13v2.0
Hras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,770,839 - 140,773,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,769,018 - 140,773,918 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387141,189,934 - 141,194,019 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,189,105 - 141,194,005 (-)Ensemblmm10GRCm38
MGSCv377148,375,833 - 148,379,903 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367141,042,668 - 141,044,260 (-)NCBIMGSCv36mm8
Celera7140,983,643 - 140,987,701 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.48NCBI
Hras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,508,126 - 11,510,333 (+)Ensembl
ChiLan1.0NW_00495547611,508,446 - 11,510,333 (+)NCBIChiLan1.0ChiLan1.0
HRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,909,695 - 2,913,028 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,126,936 - 2,130,261 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011537,488 - 540,810 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111568,305 - 571,078 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11568,305 - 571,078 (-)EnsemblpanPan2panpan1.1
HRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,642,844 - 25,644,717 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,642,844 - 25,644,717 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1825,291,831 - 25,293,704 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01826,227,144 - 26,230,043 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,220,886 - 26,230,059 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,736,932 - 25,738,805 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,381,917 - 25,383,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,994,065 - 25,995,938 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947375,371 - 378,065 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888375,377 - 377,958 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936888375,372 - 378,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2299,660 - 302,501 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12299,662 - 302,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11343,613 - 345,782 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1343,506 - 346,637 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603897,407,188 - 97,410,502 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,911,241 - 21,913,653 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476621,907,423 - 21,913,414 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hras
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v128,283,904 - 8,286,995 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hras
69 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:87
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000022363
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512205777982Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
RH94696  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,301,010 - 196,301,262 (+)MAPPERmRatBN7.2
Rnor_6.01214,183,026 - 214,183,277NCBIRnor6.0
Rnor_5.01221,100,565 - 221,100,816UniSTSRnor5.0
RGSC_v3.41201,390,327 - 201,390,578UniSTSRGSC3.4
Celera1193,934,893 - 193,935,144UniSTS
RH 3.4 Map11437.21UniSTS
Cytogenetic Map1q41UniSTS
PMC112649P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,298,157 - 196,298,354 (+)MAPPERmRatBN7.2
Rnor_6.01214,180,173 - 214,180,369NCBIRnor6.0
Rnor_5.01221,097,712 - 221,097,908UniSTSRnor5.0
RGSC_v3.41201,387,474 - 201,387,670UniSTSRGSC3.4
Celera1193,932,050 - 193,932,246UniSTS
Cytogenetic Map1q41UniSTS
PMC86690P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,298,701 - 196,299,122 (+)MAPPERmRatBN7.2
Rnor_6.01214,180,717 - 214,181,137NCBIRnor6.0
Rnor_5.01221,098,256 - 221,098,676UniSTSRnor5.0
RGSC_v3.41201,388,018 - 201,388,438UniSTSRGSC3.4
Celera1193,932,594 - 193,933,014UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001098241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC118351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY157970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO567790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022363   ⟹   ENSRNOP00000022363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1205,726,602 - 205,729,276 (-)Ensembl
mRatBN7.2 Ensembl1196,296,263 - 196,300,615 (-)Ensembl
Rnor_6.0 Ensembl1214,178,407 - 214,181,686 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079464   ⟹   ENSRNOP00000069770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1205,725,975 - 205,729,590 (-)Ensembl
mRatBN7.2 Ensembl1196,296,392 - 196,300,615 (-)Ensembl
Rnor_6.0 Ensembl1214,178,407 - 214,181,686 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000126494   ⟹   ENSRNOP00000106430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1205,727,266 - 205,729,590 (-)Ensembl
RefSeq Acc Id: NM_001098241   ⟹   NP_001091711
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,725,972 - 205,729,254 (-)NCBI
mRatBN7.21196,296,389 - 196,299,671 (-)NCBI
Rnor_6.01214,178,404 - 214,181,686 (-)NCBI
Rnor_5.01221,095,943 - 221,099,362 (-)NCBI
RGSC_v3.41201,385,705 - 201,388,987 (-)RGD
Celera1193,930,281 - 193,933,583 (-)RGD
Sequence:
RefSeq Acc Id: NM_001130441   ⟹   NP_001123913
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,725,972 - 205,729,254 (-)NCBI
mRatBN7.21196,296,389 - 196,299,671 (-)NCBI
Rnor_6.01214,178,404 - 214,181,686 (-)NCBI
Rnor_5.01221,095,943 - 221,099,362 (-)NCBI
RGSC_v3.41201,385,705 - 201,388,987 (-)RGD
Celera1193,930,281 - 193,933,583 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230535   ⟹   XP_006230597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,726,192 - 205,729,406 (-)NCBI
mRatBN7.21196,296,609 - 196,299,823 (-)NCBI
Rnor_6.01214,178,620 - 214,181,841 (-)NCBI
Rnor_5.01221,095,943 - 221,099,362 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589008   ⟹   XP_017444497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,726,602 - 205,729,298 (-)NCBI
mRatBN7.21196,296,609 - 196,299,703 (-)NCBI
Rnor_6.01214,179,070 - 214,181,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107931   ⟹   XP_038963859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,712,625 - 205,729,406 (-)NCBI
mRatBN7.21196,290,127 - 196,299,823 (-)NCBI
RefSeq Acc Id: NP_001123913   ⟸   NM_001130441
- UniProtKB: Q5RJJ8 (UniProtKB/Swiss-Prot),   Q4KLL6 (UniProtKB/Swiss-Prot),   P20171 (UniProtKB/Swiss-Prot),   A6HXQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001091711   ⟸   NM_001098241
- UniProtKB: Q5RJJ8 (UniProtKB/Swiss-Prot),   Q4KLL6 (UniProtKB/Swiss-Prot),   P20171 (UniProtKB/Swiss-Prot),   A6HXQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230597   ⟸   XM_006230535
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCK8 (UniProtKB/TrEMBL),   A0A8L2R1F7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444497   ⟸   XM_017589008
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QIP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069770   ⟸   ENSRNOT00000079464
Ensembl Acc Id: ENSRNOP00000022363   ⟸   ENSRNOT00000022363
RefSeq Acc Id: XP_038963859   ⟸   XM_039107931
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCK8 (UniProtKB/TrEMBL),   A0A8L2R1F7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106430   ⟸   ENSRNOT00000126494

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20171-F1-model_v2 AlphaFold P20171 1-189 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690533
Promoter ID:EPDNEW_R1057
Type:initiation region
Name:Hras_1
Description:HRas proto-oncogene, GTPase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01214,181,675 - 214,181,735EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2827 AgrOrtholog
BioCyc Gene G2FUF-56978 BioCyc
Ensembl Genes ENSRNOG00000016611 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022363 ENTREZGENE
  ENSRNOT00000079464 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7318824 IMAGE-MGC_LOAD
  IMAGE:7380273 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot
KEGG Report rno:293621 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105810 IMAGE-MGC_LOAD
  MGC:116273 IMAGE-MGC_LOAD
NCBI Gene Hras ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PharmGKB HRAS RGD
PhenoGen Hras PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016611 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8L2QCK8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QIP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R1F7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LT38_RAT UniProtKB/TrEMBL
  A6HXQ6 ENTREZGENE, UniProtKB/TrEMBL
  P20171 ENTREZGENE
  Q4KLL6 ENTREZGENE
  Q5RJJ8 ENTREZGENE
  RASH_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4KLL6 UniProtKB/Swiss-Prot
  Q5RJJ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-07 Hras  HRas proto-oncogene, GTPase  Hras  Harvey rat sarcoma virus oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Hras  Harvey rat sarcoma virus oncogene  Hras  Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hras  Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process decreases both expression levels and activities of dystrophin-glycoprotein complex (DGC) in muscle atrophy 625642