RGD Reference Report - Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism. - Rat Genome Database

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Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism.

Authors: Herault, J  Perrot, A  Barthelemy, C  Buchler, M  Cherpi, C  Leboyer, M  Sauvage, D  Lelord, G  Mallet, J  Muh, JP 
Citation: Herault J, etal., Psychiatry Res 1993 Mar;46(3):261-7.
RGD ID: 1358733
Pubmed: PMID:8098541   (View Abstract at PubMed)

We tested for an association between autism and genes coding for enzymes involved in monoaminergic metabolism and for a linked marker, c-Harvey-Ras-1 (HRAS 1), using restriction fragment length polymorphisms. We did not find evidence of an association between autism and genes coding for tyrosine hydroxylase, dopamine-beta-hydroxylase (DBH), and tryptophan hydroxylase. However, we report a positive association between autism and the locus containing the gene for HRAS-1.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autistic disorder  IAGP 1358733 RGD 
autistic disorder  ISOHRAS (Homo sapiens)1358733; 1358733 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hras  (HRas proto-oncogene, GTPase)

Genes (Mus musculus)
Hras  (Harvey rat sarcoma virus oncogene)

Genes (Homo sapiens)
HRAS  (HRas proto-oncogene, GTPase)


Additional Information