HRAS (HRas proto-oncogene, GTPase) - Rat Genome Database

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Gene: HRAS (HRas proto-oncogene, GTPase) Pan paniscus
Analyze
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
RGD ID: 11716276
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN cellular senescence (ortholog); defense response to protozoan (ortholog); endocytosis (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); Golgi apparatus (ortholog); GTPase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GTPase HRas; v-Ha-ras Harvey rat sarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,909,695 - 2,913,028 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,126,936 - 2,130,261 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011537,488 - 540,810 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111568,305 - 571,078 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11568,305 - 571,078 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
Alzheimer's disease  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bladder carcinoma  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cardiofaciocutaneous syndrome  (ISO)
Chanarin-Dorfman syndrome  (ISO)
chronic lymphocytic leukemia  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
congenital fibrosis of the extraocular muscles  (ISO)
Congenital Myopathy with Excess of Muscle Spindles  (ISO)
Costello syndrome  (ISO)
delta beta-thalassemia  (ISO)
developmental and epileptic encephalopathy  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
early infantile epileptic encephalopathy  (ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Follicular Thyroid Cancer  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hydrops Fetalis  (ISO)
Hypophosphatemic Rickets  (ISO)
immunodeficiency 39  (ISO)
intellectual disability  (ISO)
large congenital melanocytic nevus  (ISO)
Leber congenital amaurosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
liver cancer  (ISO)
liver carcinoma  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neoplastic Processes  (ISO)
neuroblastoma  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 3  (ISO)
obsessive-compulsive disorder  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
papilloma  (ISO)
Paraproteinemias  (ISO)
parathyroid adenoma  (ISO)
Penile Neoplasms  (ISO)
phobic disorder  (ISO)
Pigmented Nevus  (ISO)
plasma cell neoplasm  (ISO)
pre-malignant neoplasm  (ISO)
prostate adenocarcinoma  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
Recurrence  (ISO)
rhabdomyosarcoma  (ISO)
Salivary Gland Neoplasms  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
seminoma  (ISO)
skin benign neoplasm  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
spermatocytoma  (ISO)
Splenic Neoplasms  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
thymoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Trichilemmoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IEA)
cellular response to gamma radiation  (IEA)
cellular senescence  (IEA,ISO)
defense response to protozoan  (IEA,ISO)
endocytosis  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
insulin receptor signaling pathway  (IEA)
intrinsic apoptotic signaling pathway  (IEA,ISO)
liver development  (ISO)
myelination  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
oncogene-induced cell senescence  (IEA,ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of JNK cascade  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of miRNA metabolic process  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein targeting to membrane  (IEA)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of ruffle assembly  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of wound healing  (IEA)
Ras protein signal transduction  (IEA,ISO)
regulation of actin cytoskeleton organization  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of cell population proliferation  (IEA)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to isolation stress  (ISO)
Schwann cell development  (IEA)
signal transduction  (IEA)
small GTPase-mediated signal transduction  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
T-helper 1 type immune response  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,909,695 - 2,913,028 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,126,936 - 2,130,261 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011537,488 - 540,810 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111568,305 - 571,078 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11568,305 - 571,078 (-)Ensemblpanpan1.1panPan2
HRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811532,242 - 535,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11532,242 - 537,321 (-)EnsemblGRCh38hg38GRCh38
GRCh3711532,242 - 535,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611522,242 - 525,550 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411522,242 - 525,550NCBI
Celera11594,708 - 598,010 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11346,981 - 349,115 (-)NCBIHuRef
CHM1_111529,852 - 534,465 (-)NCBICHM1_1
T2T-CHM13v2.011579,238 - 582,554 (-)NCBIT2T-CHM13v2.0
Hras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,770,839 - 140,773,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,769,018 - 140,773,918 (-)EnsemblGRCm39 Ensembl
GRCm387141,189,934 - 141,194,019 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,189,105 - 141,194,005 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,375,833 - 148,379,903 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,042,668 - 141,044,260 (-)NCBIMGSCv36mm8
Celera7140,983,643 - 140,987,701 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.48NCBI
Hras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,712,625 - 205,729,406 (-)NCBIGRCr8
mRatBN7.21196,290,127 - 196,299,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,296,263 - 196,300,615 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,641,764 - 204,645,046 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,768,581 - 211,771,863 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,442,715 - 204,445,997 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,178,404 - 214,181,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,178,407 - 214,181,686 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,095,943 - 221,099,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,385,705 - 201,388,987 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,540,000 - 201,542,640 (-)NCBI
Celera1193,930,281 - 193,933,583 (-)NCBICelera
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
Hras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,508,126 - 11,510,333 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,508,446 - 11,510,333 (+)NCBIChiLan1.0ChiLan1.0
HRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,642,844 - 25,644,717 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,642,844 - 25,644,717 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,291,831 - 25,293,704 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,227,144 - 26,230,043 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,220,886 - 26,230,059 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,736,932 - 25,738,805 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,381,917 - 25,383,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,994,065 - 25,995,938 (-)NCBIUU_Cfam_GSD_1.0
Hras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947375,371 - 378,065 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888375,377 - 377,958 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888375,372 - 378,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2299,660 - 302,501 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12299,662 - 302,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11343,613 - 345,782 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1343,506 - 346,637 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,407,188 - 97,410,502 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,911,241 - 21,913,653 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,907,423 - 21,913,414 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000033472   ⟹   ENSPPAP00000010818
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11568,305 - 571,078 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000033477   ⟹   ENSPPAP00000010823
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11568,305 - 571,078 (-)Ensembl
RefSeq Acc Id: XM_034931831   ⟹   XP_034787722
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v292,909,695 - 2,913,028 (-)NCBI
NHGRI_mPanPan1112,126,936 - 2,130,261 (-)NCBI
Mhudiblu_PPA_v011537,488 - 540,810 (-)NCBI
RefSeq Acc Id: XM_034931832   ⟹   XP_034787723
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v292,910,084 - 2,912,997 (-)NCBI
NHGRI_mPanPan1112,127,325 - 2,130,235 (-)NCBI
Mhudiblu_PPA_v011537,488 - 540,806 (-)NCBI
RefSeq Acc Id: XM_034931833   ⟹   XP_034787724
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v292,909,695 - 2,912,992 (-)NCBI
NHGRI_mPanPan1112,126,936 - 2,130,235 (-)NCBI
Mhudiblu_PPA_v011537,488 - 540,806 (-)NCBI
RefSeq Acc Id: XM_055093908   ⟹   XP_054949883
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v292,909,695 - 2,911,065 (-)NCBI
NHGRI_mPanPan1112,126,936 - 2,128,598 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034787722 (Get FASTA)   NCBI Sequence Viewer  
  XP_034787723 (Get FASTA)   NCBI Sequence Viewer  
  XP_034787724 (Get FASTA)   NCBI Sequence Viewer  
  XP_054949883 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000010818.1
  ENSPPAP00000010823.1
  ENSPPAP00000029828.1
Reference Protein Sequences
RefSeq Acc Id: XP_034787722   ⟸   XM_034931831
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A1W2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787724   ⟸   XM_034931833
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A1V9 (UniProtKB/TrEMBL),   A0A2R9BKB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787723   ⟸   XM_034931832
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A1V9 (UniProtKB/TrEMBL),   A0A2R9BKB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000010818   ⟸   ENSPPAT00000033472
RefSeq Acc Id: ENSPPAP00000010823   ⟸   ENSPPAT00000033477
RefSeq Acc Id: XP_054949883   ⟸   XM_055093908
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028620 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAG00000037915 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033472.1 UniProtKB/TrEMBL
  ENSPPAT00000033477.1 UniProtKB/TrEMBL
  ENSPPAT00000052680.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/TrEMBL
NCBI Gene HRAS ENTREZGENE
PANTHER GTPASE HRAS UniProtKB/TrEMBL
  GTPASE NRAS UniProtKB/TrEMBL
  PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9A1V9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A1W2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BKB7 ENTREZGENE, UniProtKB/TrEMBL