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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2827 Species: Rattus norvegicus RGD Object: Gene Symbol: Hras Name: Harvey rat sarcoma virus oncogene

Acc ID: CHEBI:16243 Term: quercetin Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. CasRN: 117-39-5 Chemical ID: MESH:D011794

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:730881	6480464	CTD	Quercetin results in decreased expression of HRAS mRNA Quercetin results in decreased expression of HRAS protein	PMID:10652438
increases expression	ISO	RGD:730881	6480464	CTD	Quercetin results in increased expression of HRAS mRNA	PMID:21632981