RT1-Db1 (RT1 class II, locus Db1) - Rat Genome Database

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Gene: RT1-Db1 (RT1 class II, locus Db1) Rattus norvegicus
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Symbol: RT1-Db1
Name: RT1 class II, locus Db1
RGD ID: 1593282
Description: Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Involved in response to dexamethasone. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to several human genes including HLA-DRB1 (major histocompatibility complex, class II, DR beta 1); PARTICIPATES IN interleukin-12 signaling pathway; allograft rejection pathway; antigen processing and presentation pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Db1; MGC105710; MHC class II RT1D beta1 chain antigen; rano class II histocompatibility antigen, D-1 beta chain; RT1 class II histocompatibility antigen, D-1 beta chain; RT1 class II, locus Db1 (mapped); RT1-D beta; RT1-Db; RT1-Db1_mapped; RT1-Db1n
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Is Marker For: Strains:   DA.KHW-(RT1-Db1-RT1-DMb)  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,550,594 - 4,560,182 (-)NCBIGRCr8
mRatBN7.2204,548,664 - 4,558,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,548,666 - 4,558,258 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0204,087,621 - 4,097,190 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,087,618 - 4,097,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,167,759 - 6,177,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,671,489 - 4,681,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,150,824 - 6,160,393 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Actinic Prurigo  (ISO)
acute disseminated encephalomyelitis  (ISO)
Addison's disease  (ISO)
allergic asthma  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic disease  (ISO)
Alport syndrome  (ISO)
alveolar echinococcosis  (ISO)
Alzheimer's disease  (ISO)
Amebic Liver Abscess  (ISO)
angioedema  (ISO)
ankylosing spondylitis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
antiphospholipid syndrome  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atrophic gastritis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune polyendocrine syndrome  (ISO)
autoimmune polyendocrine syndrome type 2  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
bacterial infectious disease  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
celiac disease  (ISO)
cerebral infarction  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chagas Cardiomyopathy  (ISO)
Chagas disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
choreatic disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cicatricial pemphigoid  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cystic echinococcosis  (ISO)
diabetic angiopathy  (ISO)
diabetic retinopathy  (ISO)
drug allergy  (ISO)
End Stage Liver Disease  (ISO)
endometriosis  (ISO)
eosinophilia-myalgia syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (EXP)
Germ Cell and Embryonal Neoplasms  (ISO)
glaucoma  (ISO)
Graves' disease  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Hashimoto Disease  (ISO)
Helicobacter Infections  (ISO)
hepatitis C  (ISO)
HIV Seropositivity  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
hypothyroidism  (ISO)
Idiopathic Hypersomnolence  (ISO)
idiopathic pulmonary fibrosis  (ISO)
infectious mononucleosis  (ISO)
Juvenile Pauciarticular Chronic Arthritis  (ISO)
juvenile rheumatoid arthritis  (ISO)
latex allergy  (ISO)
leprosy  (ISO)
liver cirrhosis  (ISO)
lupus nephritis  (ISO)
membranous glomerulonephritis  (ISO)
Meniere's disease  (ISO)
mixed connective tissue disease  (ISO)
Multibacillary Leprosy  (ISO)
multidrug-resistant tuberculosis  (ISO)
multiple sclerosis  (ISO)
myasthenia gravis  (ISO)
Mycobacterium Infections  (ISO)
myositis  (ISO)
narcolepsy  (ISO)
Nasal Polyps  (ISO)
nephrotic syndrome  (ISO)
neuromyelitis optica  (ISO)
non-Hodgkin lymphoma  (ISO)
optic neuritis  (ISO)
Oropharyngeal Neoplasms  (ISO)
Ovarian Neoplasms  (ISO)
pancreatitis  (ISO)
papillomavirus infectious disease  (ISO)
paracoccidioidomycosis  (ISO)
Parkinson's disease  (ISO)
pemphigus  (ISO)
peptic ulcer disease  (ISO)
PERITONEAL GLIOMATOSIS  (ISO)
Pneumocystis Infections  (IEP)
polyneuropathy  (ISO)
primary progressive multiple sclerosis  (ISO)
prostate cancer  (ISO)
proteasome-associated autoinflammatory syndrome 1  (ISO)
proteinuria  (ISO)
Pulmonary Atresia  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pure red-cell aplasia  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
renal cell carcinoma  (ISO)
retinopathy of prematurity  (ISO)
rheumatic fever  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
schistosomiasis  (ISO)
schizophrenia  (ISO)
sensorineural hearing loss  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
sympathetic ophthalmia  (ISO)
systemic lupus erythematosus  (ISO)
Takayasu's arteritis  (ISO)
temporal arteritis  (ISO)
thromboangiitis obliterans  (ISO)
toxic shock syndrome  (ISO)
Trichiasis  (ISO)
tuberculosis  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
type 1 diabetes mellitus  (ISO)
typhoid fever  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Uterine Cervical Neoplasms  (ISO)
uveitis  (ISO)
uveoparotid fever  (ISO)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
vulva cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (ISO)
3,7-dihydropurine-6-thione  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
auranofin  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beryllium sulfate  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cefepime  (ISO)
celecoxib  (ISO)
choline  (ISO)
ciprofloxacin  (ISO)
clindamycin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
diltiazem  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
epoxiconazole  (ISO)
ethylbenzene  (EXP)
ethylparaben  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hexachlorobenzene  (EXP)
hydrochlorothiazide  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
lead(0)  (ISO)
lumiracoxib  (ISO)
mercaptopurine  (EXP,ISO)
metronidazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-(6-acetamidohexyl)acetamide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nitric oxide  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
palladium  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
purine-6-thiol  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
antigen processing and presentation of endogenous peptide antigen via MHC class II  (ISO)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (IBA,ISO)
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II  (IEA)
humoral immune response  (ISO)
immune response  (ISO)
inflammatory response to antigenic stimulus  (ISO)
macrophage differentiation  (ISO)
myeloid dendritic cell antigen processing and presentation  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of type II interferon production  (ISO)
peptide antigen assembly with MHC class II protein complex  (IBA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of CD4-positive, alpha-beta T cell activation  (ISO)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of immune response  (IBA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of memory T cell differentiation  (ISO)
positive regulation of monocyte differentiation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of T cell activation  (IBA)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of T cell mediated immune response to tumor cell  (ISO)
positive regulation of viral entry into host cell  (ISO)
protein tetramerization  (ISO)
regulation of interleukin-10 production  (ISO)
regulation of interleukin-4 production  (ISO)
regulation of T-helper cell differentiation  (ISO)
response to dexamethasone  (IEP)
response to organic substance  (IEP)
response to type II interferon  (ISO)
signal transduction  (ISO)
T cell receptor signaling pathway  (ISO)
T-helper 1 type immune response  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Human leukocyte antigen (HLA)-B, DRB1, and DQB1 allotypes associated with disease and protection of trachoma endemic villagers. Abbas M, etal., Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1734-8. doi: 10.1167/iovs.08-2053. Epub 2008 Sep 29.
2. Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice. Adamus G, etal., Invest Ophthalmol Vis Sci. 2012 Jan 25;53(1):406-12. doi: 10.1167/iovs.11-8419.
3. Selected class I and class II HLA alleles and haplotypes and risk of high-grade cervical intraepithelial neoplasia. Ades S, etal., Int J Cancer. 2008 Jun 15;122(12):2820-6.
4. Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals. Agliardi C, etal., Brain Behav Immun. 2011 Jun 12.
5. Strong association of HLA class II sequences in Mexicans with Vogt-Koyanagi-Harada's disease. Alaez C, etal., Hum Immunol. 1999 Sep;60(9):875-82.
6. The rheumatoid arthritis-associated allele HLA-DR10 (DRB1*1001) shares part of its repertoire with HLA-DR1 (DRB1*0101) and HLA-DR4 (DRB*0401). Alvarez I, etal., Arthritis Rheum. 2008 Jun;58(6):1630-9.
7. Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study. Alves-Leon SV, etal., Arq Neuropsiquiatr. 2009 Sep;67(3A):643-51.
8. Human leukocyte antigen-DQB1 and -DRB1 associations in patients with idiopathic sudden sensorineural hearing loss from a defined population of Northwest Spain. Amor-Dorado JC, etal., Acta Otolaryngol. 2005 Dec;125(12):1277-82.
9. Relationship between HLA-DR antigen and HLA-DRB1 alleles and prostate cancer in Japanese men. Azuma H, etal., Int Urol Nephrol. 1999;31(3):343-9.
10. HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia? Baccar Harrath A, etal., Pathol Oncol Res. 2006;12(2):79-81. Epub 2006 Jun 24.
11. Alport syndrome: HLA association and kidney graft outcome. Barocci S, etal., Eur J Immunogenet. 2004 Jun;31(3):115-9.
12. Association of tumor necrosis factor and human leukocyte antigen DRB1 alleles with Graves' ophthalmopathy. Bednarczuk T, etal., Hum Immunol. 2004 Jun;65(6):632-9.
13. To B or not to B: Role of B cells in pathogenesis of arthritis in HLA transgenic mice. Behrens M, etal., J Autoimmun. 2011 Jun 10.
14. Genetic basis of the latex-fruit syndrome: association with HLA class II alleles in a Spanish population. Blanco C, etal., J Allergy Clin Immunol. 2004 Nov;114(5):1070-6.
15. [HLA-DRB1 typing in Caucasians patients with neuromyelitis optica.] Blanco Y, etal., Rev Neurol. 2011 Aug 1;53(3):146-152.
16. HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis. Bonagura VR, etal., Hum Immunol. 2004 Aug;65(8):773-82.
17. Carriage of DRB1*13 is associated with increased posttreatment IgE levels against Schistosoma mansoni antigens and lower long-term reinfection levels. Booth M, etal., J Immunol. 2006 Jun 1;176(11):7112-8. doi: 10.4049/jimmunol.176.11.7112.
18. HLA status in patients with chronic spontaneous urticaria. Bozek A, etal., Int Arch Allergy Immunol. 2010;153(4):419-23. Epub 2010 Jun 18.
19. Increased occurrence of anti-AQP4 seropositivity and unique HLA Class II associations with neuromyelitis optica (NMO), among Muslim Arabs in Israel. Brill L, etal., J Neuroimmunol. 2016 Apr 15;293:65-70. doi: 10.1016/j.jneuroim.2016.02.006. Epub 2016 Feb 15.
20. Analysis of maternal-offspring HLA compatibility, parent-of-origin effects, and noninherited maternal antigen effects for HLA-DRB1 in systemic lupus erythematosus. Bronson PG, etal., Arthritis Rheum. 2010 Jun;62(6):1712-7.
21. Occurrence rates of HLA-DRB1, HLA-DQB1, and HLA-DPB1 alleles in patients suffering from vitiligo. Buc M, etal., Eur J Dermatol. 1998 Jan-Feb;8(1):13-5.
22. HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients. Caliz R, etal., Rheumatology (Oxford). 2001 Jan;40(1):31-6.
23. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. Campbell JD, etal., J Exp Med. 2009 Jul 6;206(7):1535-47. Epub 2009 Jun 15.
24. HLA class II-associated genetic susceptibility in idiopathic progressive sensorineural hearing loss. Cao MY, etal., Ann Otol Rhinol Laryngol. 1996 Aug;105(8):628-33.
25. Tumour necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis. Castro F, etal., Ann Rheum Dis. 2001 Aug;60(8):791-5.
26. HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women. Cervantes J, etal., Hum Immunol. 2003 Sep;64(9):890-5.
27. Comprehensive genotyping in two homogeneous Graves' disease samples reveals major and novel HLA association alleles. Chen PL, etal., PLoS One. 2011 Jan 28;6(1):e16635. doi: 10.1371/journal.pone.0016635.
28. Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages. Cheng BH, etal., BMC Microbiol. 2010 Apr 8;10:103.
29. Association of HLA-DRB1 alleles and neuropsychological function in autism. Chien YL, etal., Psychiatr Genet. 2011 Jun 28.
30. Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies. Chinoy H, etal., Rheumatology (Oxford). 2007 Sep;46(9):1411-6. Epub 2007 Jun 22.
31. The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma. Choi JH, etal., Int Arch Allergy Immunol. 2009;150(2):156-63. Epub 2009 May 12.
32. Distribution of the human leukocyte antigen class II alleles in Brazilian patients with chronic hepatitis C virus infection. Corghi DB, etal., Braz J Med Biol Res. 2008 Oct;41(10):884-9. Epub 2008 Sep 30.
33. Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women. Cuzick J, etal., Br J Cancer. 2000 Apr;82(7):1348-52.
34. HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance. da Silva SA, etal., BMC Infect Dis. 2009 Aug 22;9:134.
35. HLA-DRB1* alleles and symptoms associated with Heerfordt's syndrome in sarcoidosis. Darlington P, etal., Eur Respir J. 2011 Jun 9.
36. Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women. Davidson EJ, etal., Cancer Res. 2003 Jan 15;63(2):400-3.
37. Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome. de Gruijl TD, etal., J Gen Virol. 1999 Feb;80 ( Pt 2):399-408.
38. HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis. Djilali-Saiah I, etal., J Hepatol. 2006 Dec;45(6):844-50. Epub 2006 Sep 28.
39. HLA-DRB1 and HLA-DQB1 genes in susceptibility and resistance to cicatricial pemphigoid in French Caucasians. Drouet M, etal., Eur J Dermatol. 1998 Jul-Aug;8(5):330-3.
40. HLA class II alleles as markers of tuberculosis susceptibility and resistance. Duarte R, etal., Rev Port Pneumol. 2011 Jan;17(1):15-9.
41. Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam. Dunstan SJ, etal., J Infect Dis. 2001 Jan 15;183(2):261-268. doi: 10.1086/317940. Epub 2000 Dec 21.
42. Variation at HLA-DRB1 is associated with resistance to enteric fever. Dunstan SJ, etal., Nat Genet. 2014 Dec;46(12):1333-6. doi: 10.1038/ng.3143. Epub 2014 Nov 10.
43. No association between bronchial asthma and HLA-DRB1, -DQB1 alleles in the Slovak population. Dzurilla M, etal., Bratisl Lek Listy. 2013;114(2):93-5.
44. HLA and alveolar echinococcosis. Eiermann TH, etal., Tissue Antigens. 1998 Aug;52(2):124-9. doi: 10.1111/j.1399-0039.1998.tb02275.x.
45. Heterozygosity or homozygosity for 2 HLA class II haplotypes predict favorable outcomes for renal cell carcinoma treated with cytokine therapy. Ellerhorst JA, etal., J Urol. 2003 Jun;169(6):2084-8.
46. Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry. Erichsen MM, etal., J Clin Endocrinol Metab. 2009 Dec;94(12):4882-90. Epub 2009 Oct 26.
47. HLA-DRB and HLA-DQ genetic variability in patients with aspirin-exacerbated respiratory disease. Esmaeilzadeh H, etal., Am J Rhinol Allergy. 2015 May-Jun;29(3):e63-9. doi: 10.2500/ajra.2015.29.4154.
48. HLA class II haplotype DRB1*04-DQB1*0301 contributes to risk of familial generalized vitiligo and early disease onset. Fain PR, etal., Pigment Cell Res. 2006 Feb;19(1):51-7.
49. HLA profile in patients with AIDS and tuberculosis. Figueiredo JF, etal., Braz J Infect Dis. 2008 Aug;12(4):278-80. doi: 10.1590/s1413-86702008000400004.
50. The role of the human leukocyte antigen system in retinopathy of prematurity: a pilot study. Flor-de-Lima F, etal., Acta Paediatr. 2013 Aug 29. doi: 10.1111/apa.12410.
51. Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. Flynn JC, etal., J Autoimmun. 2002 May;18(3):213-20.
52. Distribution of HLA-DRB1 alleles in Argentinean patients with Chagas' disease cardiomyopathy. Garcia Borras S, etal., Immunol Invest. 2009;38(3-4):268-75.
53. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
54. HLA-DBR 1 alleles and the susceptibility of Iranian patients with breast cancer. Ghaderi A, etal., Pathol Oncol Res. 2001;7(1):39-41.
55. HLA-DRB and HLA-DQB loci in the genetic susceptibility to develop glaucoma in Mexicans. Gil-Carrasco F, etal., Am J Ophthalmol. 1999 Sep;128(3):297-300.
56. HLA-DRB1*0405 is the predominant allele in Brazilian patients with Vogt-Koyanagi-Harada disease. Goldberg AC, etal., Hum Immunol. 1998 Mar;59(3):183-8.
57. Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus. Goldberg AC, etal., Hum Immunol. 2001 Feb;62(2):165-9.
58. Human leukocyte antigen (HLA) class I and II alleles in Turkish patients with rheumatic heart disease. Gundogdu F, etal., J Heart Valve Dis. 2007 May;16(3):293-9.
59. Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis. Haas JP, etal., Clin Exp Rheumatol. 1994 Sep-Oct;12 Suppl 10:S7-14.
60. Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients. Han YN, etal., World J Gastroenterol. 2005 Sep 28;11(36):5721-4. doi: 10.3748/wjg.v11.i36.5721.
61. Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population. Hashimoto K, etal., Horm Res. 2005;64(5):253-60. Epub 2005 Oct 27.
62. MICA4/HLA-DRB1*04/TNF1 haplotype is associated with mixed connective tissue disease in Swedish patients. Hassan AB, etal., Hum Immunol. 2003 Feb;64(2):290-6.
63. Prevalent HLA Class II Alleles in Mexico City Appear to Confer Resistance to the Development of Amebic Liver Abscess. Hernández EG, etal., PLoS One. 2015 May 4;10(5):e0126195. doi: 10.1371/journal.pone.0126195. eCollection 2015.
64. Association of HLA-DRB1*0405 with resistance to multibacillary leprosy in Taiwanese. Hsieh NK, etal., Hum Immunol. 2010 Jul;71(7):712-6. Epub 2010 Apr 9.
65. [Possible association between HLA-HRB1 and DQB1 genes frequency and susceptibility or resistance to Helicobacter pylori infection in Kunming Yi ethnic group children]. Huang YK, etal., Zhonghua Er Ke Za Zhi. 2005 Feb;43(2):137-40.
66. HLA-DR alleles determine responsiveness to Borrelia burgdorferi antigens in a mouse model of self-perpetuating arthritis. Iliopoulou BP, etal., Arthritis Rheum. 2009 Dec;60(12):3831-40.
67. Does HLA Class II haplotype play a role in adult acute disseminated encephalomyelitis? Preliminary findings from a Southern Italy hospital-based study. Imbesi D, etal., Arch Ital Biol. 2012 Mar;150(1):1-4. doi: 10.4449/aib.v150i1.1384.
68. The distribution of HLA alleles among children with atopic asthma in Croatia. Ivkovic-Jurekovic I, etal., Coll Antropol. 2011 Dec;35(4):1243-9.
69. Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. Julg B, etal., J Infect Dis. 2011 Mar 15;203(6):803-9. Epub 2011 Jan 21.
70. The association between the HLA system and retinopathy development in patients with type 1 diabetes mellitus. Kastelan S, etal., Coll Antropol. 2013 Apr;37 Suppl 1:65-70.
71. Effect of human leukocyte antigen class II genes on acute-onset and slow-onset type 1 diabetes in the Japanese population. Katahira M, etal., Hum Immunol. 2010 Aug;71(8):789-94. Epub 2010 May 25.
72. HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice. Khare M, etal., J Neuroimmunol. 2005 Dec;169(1-2):1-12. Epub 2005 Sep 27.
73. Immunogenetics and clinical phenotype of sympathetic ophthalmia in British and Irish patients. Kilmartin DJ, etal., Br J Ophthalmol. 2001 Mar;85(3):281-6.
74. Korean Red Ginseng Up-regulates C21-Steroid Hormone Metabolism via Cyp11a1 Gene in Senescent Rat Testes. Kim IH, etal., J Ginseng Res. 2011 Sep;35(3):272-82. doi: 10.5142/jgr.2011.35.3.272.
75. Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ. Knutsen AP, etal., Allergy. 2010 Nov;65(11):1367-75. doi: 10.1111/j.1398-9995.2010.02382.x. Epub 2010 Jun 16.
76. Association between HLA Class II alleles with HPV mediated Cervical Cancer in Indian women. Kohaar I, etal., Hum Immunol. 2009 Jan 17.
77. HLA-DRB genotypes in Japanese patients with renal cell carcinoma. Kojima Y, etal., Oncology. 2000 Jun;59(1):57-62.
78. Major histocompatibility complex class II (DRB1*, DQA1*, and DQB1*) and DRB1*04 subtypes' associations of Hashimoto's thyroiditis in a Greek population. Kokaraki G, etal., Tissue Antigens. 2009 Mar;73(3):199-205.
79. Efficacy of HLA-DRB1 *03:01 and H2E transgenic mouse strains to correlate pathogenic thyroglobulin epitopes for autoimmune thyroiditis. Kong YC, etal., J Autoimmun. 2011 Jun 17.
80. [HLA-DRB1/DQA1/DQB1 alleles and haplotypes in Czech children with celiac sprue]. Kotalova R, etal., Cas Lek Cesk. 2002 Aug 16;141(16):518-22.
81. HLA associations with multiple sclerosis in Greece. Kouri I, etal., J Neurol Sci. 2011 Jul 7.
82. Genetic alterations of HLA-class II in ovarian cancer. Kubler K, etal., Int J Cancer. 2008 Sep 15;123(6):1350-6.
83. The role of HLA molecules in susceptibility to chronic rheumatic heart disease. Kudat H, etal., Int J Immunogenet. 2006 Feb;33(1):41-4.
84. The 8.1 ancestral MHC haplotype is associated with delayed onset of colonization in cystic fibrosis. Laki J, etal., Int Immunol. 2006 Nov;18(11):1585-90. Epub 2006 Sep 20.
85. Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population. Lara-Marquez ML, etal., Clin Exp Allergy 1999 Jan;29(1):60-71.
86. HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California. Levinson RD, etal., Hum Immunol. 2004 Dec;65(12):1477-82.
87. Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. Levinson RD, etal., Invest Ophthalmol Vis Sci. 2003 Feb;44(2):653-7.
88. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. Li X, etal., J Allergy Clin Immunol. 2010 Feb;125(2):328-335.e11. doi: 10.1016/j.jaci.2009.11.018.
89. A three-way interplay of DR4, autoantibodies and synovitis in biopsy-proven idiopathic inflammatory myositis. Limaye VS, etal., Rheumatol Int. 2010 Dec 2.
90. HLA class I and II alleles are associated with microvascular complications of type 1 diabetes. Lipner EM, etal., Hum Immunol. 2013 May;74(5):538-44. doi: 10.1016/j.humimm.2013.01.013. Epub 2013 Jan 29.
91. [Association of haplotype formed on HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection]. Lu LP, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Aug;23(4):427-30.
92. [Distribution of HLA specificity frequencies in patients with cystic echinococcosis]. Lukmanova GI, etal., Med Parazitol (Mosk). 2011 Oct-Dec;(4):14-6.
93. The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients. Luo H, etal., BMC Nephrol. 2011 May 13;12:21.
94. Can the prognosis of polymyalgia rheumatica be predicted at disease onset? Results from a 5-year prospective study. Mackie SL, etal., Rheumatology (Oxford). 2010 Apr;49(4):716-22. Epub 2010 Jan 11.
95. Human leukocyte antigen class II and cervical cancer risk: a population-based study. Madeleine MM, etal., J Infect Dis. 2002 Dec 1;186(11):1565-74. Epub 2002 Nov 4.
96. Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes. Manan H, etal., Hum Immunol. 2010 Dec;71(12):1238-42. Epub 2010 Sep 19.
97. Human leukocyte antigen type and progression from onset of symptoms to development of asthma. Martyn MB, etal., Allergy Asthma Proc. 2010 Mar;31(2):120-5. Epub 2010 Mar 8.
98. Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer. Matsumoto K, etal., Int J Cancer. 2003 Oct 10;106(6):919-22.
99. HLA class II antigens positively and negatively associated with hepatosplenic schistosomiasis in a Chinese population. McManus DP, etal., Int J Parasitol. 2001 May 15;31(7):674-80. doi: 10.1016/s0020-7519(01)00132-1.
100. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Mignot E, etal., Am J Hum Genet. 2001 Mar;68(3):686-99. Epub 2001 Feb 13.
101. Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. Miyagawa T, etal., J Hum Genet. 2010 Jan;55(1):63-5. Epub 2009 Nov 20.
102. Human leukocyte antigen serologic and DNA typing of Behcet's disease and its primary association with B51. Mizuki N, etal., Invest Ophthalmol Vis Sci. 1992 Nov;33(12):3332-40.
103. HLA-A*11 and novel associations in Malays and Chinese with systemic lupus erythematosus. Mohd-Yusuf Y, etal., Immunol Lett. 2011 Sep 30;139(1-2):68-72. Epub 2011 May 30.
104. HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis. Molnar-Gabor E, etal., Laryngoscope. 2000 Mar;110(3 Pt 1):422-5.
105. Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis. Morgan AW, etal., Arthritis Res Ther. 2006;8(4):R109.
106. Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity. Moriguchi M, etal., Metabolism. 2011 Jun;60(6):761-6. Epub 2010 Sep 9.
107. HLA-DRB1 and HLA-DQB1 genes on susceptibility to and protection from allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Muro M, etal., Microbiol Immunol. 2013 Mar;57(3):193-7. doi: 10.1111/1348-0421.12020.
108. Associations of MHC class II alleles in Norwegian primary Sjogren's syndrome patients: implications for development of autoantibodies to the Ro52 autoantigen. Nakken B, etal., Scand J Immunol. 2001 Oct;54(4):428-33.
109. Amyloid beta-HSP60 peptide conjugate vaccine treats a mouse model of Alzheimer's disease. Nemirovsky A, etal., Vaccine. 2011 May 23;29(23):4043-50. Epub 2011 Apr 5.
110. Hinyokika kiyo. Acta urologica Japonica Nishimura K, etal., Hinyokika Kiyo. 1996 Feb;42(2):95-9.
111. [Immune polymorphism analysis of HLA class II antigens in ulcer diseases associated with Helicobacter pylori in children]. Nizhevich AA, etal., Eksp Klin Gastroenterol. 2010;(1):58-63.
112. Genetic analysis of HLA- and HPA-typing in idiopathic (autoimmune) thrombocytopenic purpura patients treated with cepharanthin. Nomura S, etal., Autoimmunity. 1999;30(2):99-105.
113. Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. O'Hanlon TP, etal., Medicine (Baltimore). 2006 Mar;85(2):111-27.
114. Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study. Ogata T, etal., BMC Med Genet. 2006 Jul 31;7:67.
115. Immunogenetic characteristics of patients with autoimmune gastritis. Oksanen AM, etal., World J Gastroenterol. 2010 Jan 21;16(3):354-8.
116. HLA-DRB alleles are differentially expressed by tumor cells in breast carcinoma. Oldford SA, etal., Int J Cancer. 2004 Nov 10;112(3):399-406.
117. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
118. Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes. Orchard TR, etal., Gastroenterology. 2002 Sep;123(3):714-8.
119. High-resolution HLA-DRB1 and DQB1 genotyping in Japanese patients with testicular germ cell carcinoma. Ozdemir E, etal., Br J Cancer. 1997;76(10):1348-52.
120. HLA-DRB1*0101 and *0405 as protective alleles in Japanese patients with renal cell carcinoma. Ozdemir E, etal., Cancer Res. 1997 Feb 15;57(4):742-6.
121. Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients. Pachot A, etal., Crit Care Med. 2005 Jan;33(1):31-8; discussion 236-7.
122. Pediatric and adult forms of type I autoimmune hepatitis in Argentina: evidence for differential genetic predisposition. Pando M, etal., Hepatology. 1999 Dec;30(6):1374-80.
123. HLA DQA1*0501 and DRB1*0301 antigens do not independently convey susceptibility to Graves' disease. Philippou G, etal., J Endocrinol Invest. 2001 Feb;24(2):88-91.
124. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
125. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
126. The association of anti-r-HuEpo-associated pure red cell aplasia with HLA-DRB1*09-DQB1*0309. Praditpornsilpa K, etal., Nephrol Dial Transplant. 2009 May;24(5):1545-9. doi: 10.1093/ndt/gfn450. Epub 2008 Aug 8.
127. Nationwide collaborative study of HLA class II associations with distinct types of juvenile chronic arthritis (JCA) in Greece. Pratsidou-Gertsi P, etal., Eur J Immunogenet. 1999 Aug;26(4):299-310.
128. Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia. Qiu W, etal., J Clin Neurosci. 2010 Aug;17(8):1009-13. Epub 2010 May 23.
129. Transfer of the shared epitope through microchimerism in women with rheumatoid arthritis. Rak JM, etal., Arthritis Rheum. 2009 Jan;60(1):73-80.
130. Association of HLA DQ B1* and HLA DR B1* alleles with goitrous juvenile autoimmune hypothyroidism--a case control study. Rekha PL, etal., J Clin Immunol. 2007 Sep;27(5):486-9. Epub 2007 Jun 22.
131. GOA pipeline RGD automated data pipeline
132. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
133. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
134. Comprehensive gene review and curation RGD comprehensive gene curation
135. Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus. Richards KA, etal., J Virol. 2009 Jul;83(13):6566-77. Epub 2009 Apr 22.
136. HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. Rossman MD, etal., Am J Hum Genet. 2003 Oct;73(4):720-35. Epub 2003 Aug 20.
137. Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors. Saad AH, etal., J Egypt Soc Parasitol. 2006 Dec;36(3):889-910.
138. Generic human leukocyte antigen class II (DRB1 and DQB1) alleles in patients with paracoccidioidomycosis. Sadahiro A, etal., Med Mycol. 2007 Feb;45(1):35-40.
139. Association of the human leucocyte antigen region with susceptibility to Parkinson's disease. Saiki M, etal., J Neurol Neurosurg Psychiatry. 2010 Aug;81(8):890-1. Epub 2010 May 12.
140. Association of hypersensitivity to the nematode Anisakis simplex with HLA class II DRB1*1502-DQB1*0601 haplotype. Sanchez-Velasco P, etal., Hum Immunol. 2000 Mar;61(3):314-9.
141. Sensitivity to bee venom antigen phospholipase A2: association with specific HLA class I and class II alleles and haplotypes in beekeepers and allergic patients. Sanchez-Velasco P, etal., Hum Immunol. 2005 Jul;66(7):818-25.
142. Regression of low-grade cervical intraepithelial neoplasia in patients with HLA-DRB1*13 genotype. Sastre-Garau X, etal., Obstet Gynecol. 2004 Oct;104(4):751-5.
143. HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris. Shams S, etal., J Clin Immunol. 2009 Mar;29(2):175-9. Epub 2008 Sep 9.
144. Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus-infected patients of Mumbai, India. Shankarkumar U, etal., Int J Immunogenet. 2010 Jun;37(3):199-204. Epub 2010 Mar 14.
145. Clinical and genetic risk factors for the development of multi-drug resistant tuberculosis in non-HIV infected patients at a tertiary care center in India: a case-control study. Sharma SK, etal., Infect Genet Evol. 2003 Sep;3(3):183-8.
146. Immunogenetic study of sympathetic ophthalmia. Shindo Y, etal., Tissue Antigens. 1997 Feb;49(2):111-5.
147. A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan. Shinomiya N, etal., Clin Immunol. 2004 Feb;110(2):154-8.
148. Multiple Loci in the HLA Complex Are Associated with Addison's Disease. Skinningsrud B, etal., J Clin Endocrinol Metab. 2011 Aug 3.
149. Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02. Smyth CM, etal., Eur J Gastroenterol Hepatol. 2007 Jun;19(6):493-8. doi: 10.1097/MEG.0b013e328010687d.
150. HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children. Stanevicha V, etal., Arthritis Res Ther. 2007;9(3):R58.
151. Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1. Sundqvist J, etal., Fertil Steril. 2011 Jan;95(1):437-40. Epub 2010 Aug 24.
152. Increased frequency of HLA-DRB1*15 in patients with multifocal motor neuropathy. Sutedja NA, etal., Neurology. 2010 Mar 9;74(10):828-32.
153. Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles. Suzuki H, etal., Invest Ophthalmol Vis Sci. 2012 Oct 11;53(11):7109-15. doi: 10.1167/iovs.12-10491.
154. HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom. Suzuki K, etal., Tissue Antigens. 2005 May;65(5):459-66.
155. Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships. Tang J, etal., PLoS One. 2010 Mar 10;5(3):e9629.
156. Sequence feature variant type (sfvt) analysis of the hla genetic association in juvenile idiopathic arthritis. Thomson G, etal., Pac Symp Biocomput. 2010:359-70.
157. A shared HLA-DRB1 epitope in the DR beta first domain is associated with Vogt-Koyanagi-Harada syndrome in Indian patients. Tiercy JM, etal., Mol Vis. 2010 Mar 5;16:353-8.
158. Low frequency of HLA-DRB1*11 in hepatitis C virus induced end stage liver disease. Tillmann HL, etal., Gut. 2001 May;48(5):714-8. doi: 10.1136/gut.48.5.714.
159. Strain-based HLA association analysis identified HLA-DRB1*09:01 associated with modern strain tuberculosis. Toyo-Oka L, etal., HLA. 2017 Sep;90(3):149-156. doi: 10.1111/tan.13070. Epub 2017 Jun 14.
160. HLA-DRB1 allele distribution and its relation to rheumatoid arthritis in eastern Black Sea Turkish population. Ucar F, etal., Rheumatol Int. 2011 Jan 19.
161. Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis. Vasconcelos CC, etal., J Neuroimmunol. 2009 Sep 29;214(1-2):101-3. Epub 2009 Jul 17.
162. Differences in the genetic background of latent autoimmune diabetes in adults (LADA) and type 1 diabetes mellitus. Vatay A, etal., Immunol Lett. 2002 Nov 1;84(2):109-115.
163. Analysis of B- and T-cell clonality and HLA class II alleles in patients with idiopathic thrombocytopenic purpura: correlation with Helicobacter pylori infection and response to eradication treatment. Veneri D, etal., Platelets. 2005 Aug;16(5):307-11.
164. Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Wagner AM, etal., Diabetes Metab Res Rev. 2011 Jul;27(5):493-498. doi: 10.1002/dmrr.1189.
165. Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis. Ward MM, etal., Arthritis Rheum. 2009 Jul 15;61(7):859-66.
166. Autoimmune polyglandular syndrome type 2 shows the same HLA class II pattern as type 1 diabetes. Weinstock C, etal., Tissue Antigens. 2011 Apr;77(4):317-24. doi: 10.1111/j.1399-0039.2011.01634.x.
167. Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. Wiseman MC, etal., J Am Acad Dermatol. 2001 Jun;44(6):952-6.
168. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis among the Chinese Kazakh population: a case-control study. Wu F, etal., Biomed Res Int. 2013;2013:484535. doi: 10.1155/2013/484535. Epub 2013 Sep 1.
169. Influence of HLA-DRB1 allele heterogeneity on disease risk and clinical course in a West Australian MS cohort: a high-resolution genotyping study. Wu JS, etal., Mult Scler. 2010 May;16(5):526-32. Epub 2010 Mar 5.
170. Association between HLA-DRB1 and myasthenia gravis in a northern Han Chinese population. Xie YC, etal., J Clin Neurosci. 2011 Nov;18(11):1524-7. doi: 10.1016/j.jocn.2011.05.002. Epub 2011 Sep 15.
171. The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis. Xue J, etal., PLoS One. 2011 Feb 23;6(2):e14715.
172. Autoimmunity against neurofilament protein and its possible association with HLA-DRB1*1502 allele in glaucoma. Yano T, etal., Immunol Lett. 2005 Sep 15;100(2):164-9.
173. Distribution of HLA-A, -B and -DRB1 alleles in patients with sudden sensorineural hearing loss. Yeo SW, etal., Acta Otolaryngol. 2000 Sep;120(6):710-5.
174. Influence of human leukocyte antigen in the pathogenesis of Meniere's disease in the South Korean population. Yeo SW, etal., Acta Otolaryngol. 2002 Dec;122(8):851-6.
175. Genetic analysis of the HLA region of Japanese patients with type 1 autoimmune hepatitis. Yoshizawa K, etal., J Hepatol. 2005 Apr;42(4):578-84. Epub 2005 Jan 21.
176. Common major histocompatibility complex class II markers in clinical variants of cicatricial pemphigoid. Yunis JJ, etal., Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7747-51.
177. Association of HLA-DRB1*13 with susceptibility to uveitis in juvenile idiopathic arthritis in two independent data sets. Zeggini E, etal., Rheumatology (Oxford). 2006 Aug;45(8):972-4. Epub 2006 Feb 22.
178. Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population. Zhang F, etal., BMC Med Genet. 2009 Dec 11;10:133.
179. Relationship between HLA-DRB1 polymorphism and susceptibility or resistance to multiple sclerosis in Caucasians: a meta-analysis of non-family-based studies. Zhang Q, etal., Autoimmun Rev. 2011 Jun;10(8):474-81. Epub 2011 Apr 2.
180. Evidence for human leukocyte antigen-related susceptibility in idiopathic childhood ischemic stroke. Zou LP, etal., Eur Neurol. 2002;48(3):153-7.
Additional References at PubMed
PMID:1300424   PMID:1448172   PMID:2388838   PMID:7477400   PMID:7606781   PMID:9354468   PMID:9745012   PMID:10369938   PMID:11027433   PMID:11465104   PMID:11714799   PMID:12136338  
PMID:12477932   PMID:12519789   PMID:15517241   PMID:15795121   PMID:16502470   PMID:18039812   PMID:18305173   PMID:19946888   PMID:20458337   PMID:20543955   PMID:21484216   PMID:21502329  
PMID:22321387   PMID:22733780   PMID:23376485   PMID:24586191   PMID:24942581  


Genomics

Comparative Map Data
RT1-Db1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,550,594 - 4,560,182 (-)NCBIGRCr8
mRatBN7.2204,548,664 - 4,558,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,548,666 - 4,558,258 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0204,087,621 - 4,097,190 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,087,618 - 4,097,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,167,759 - 6,177,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,671,489 - 4,681,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,150,824 - 6,160,393 (-)NCBICelera
Cytogenetic Map20p12NCBI
HLA-DRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,578,775 - 32,589,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,577,902 - 32,589,848 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,546,552 - 32,557,625 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,654,527 - 32,665,559 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,654,526 - 32,665,559NCBI
Cytogenetic Map6p21.32NCBI
CHM1_1632,549,025 - 32,560,089 (-)NCBICHM1_1
T2T-CHM13v2.0632,408,987 - 32,422,414 (-)NCBIT2T-CHM13v2.0
H2-Eb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,524,841 - 34,535,648 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,524,841 - 34,535,648 (+)EnsemblGRCm39 Ensembl
GRCm381734,305,867 - 34,316,674 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,305,867 - 34,316,674 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,442,812 - 34,453,619 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,913,637 - 33,923,895 (+)NCBIMGSCv36mm8
Celera1737,067,715 - 37,078,914 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
HLA-DRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,151,409 - 2,164,564 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,300,636 - 2,313,266 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,427,792 - 2,440,407 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1122,150,930 - 2,163,511 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,232,117 - 2,244,754 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,306,389 - 2,319,034 (-)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in RT1-Db1
1156 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:270
Count of miRNA genes:148
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000000522, ENSRNOT00000060327
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
7175099Tcs2T cell selection QTL 2T cell selectionexpression2045040024693102Rat


Related Rat Strains
The following Strains have been annotated to RT1-Db1
DA.KHW-(RT1-Db1-RT1-DMb)    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 23 9 19 9 2 18 9 11
Low 19 18 16 16 8 9 25 11 21 8
Below cutoff 18 16 16 16 39 6 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF084933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF246657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ003231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ003234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY626207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO563535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV111238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000522   ⟹   ENSRNOP00000000522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,548,666 - 4,558,237 (-)Ensembl
Rnor_6.0 Ensembl204,087,618 - 4,097,090 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000060327   ⟹   ENSRNOP00000057075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,549,323 - 4,558,240 (-)Ensembl
Rnor_6.0 Ensembl204,087,644 - 4,097,089 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,094,738 - 4,097,078 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,556,337 - 4,558,165 (-)Ensembl
Rnor_6.0 Ensembl204,087,693 - 4,089,521 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080590   ⟹   ENSRNOP00000069704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,549,323 - 4,558,240 (-)Ensembl
Rnor_6.0 Ensembl204,087,685 - 4,096,777 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,096,432 - 4,097,190 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,087,687 - 4,092,207 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,087,703 - 4,092,325 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113681   ⟹   ENSRNOP00000080217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,548,666 - 4,558,258 (-)Ensembl
RefSeq Acc Id: NM_001008884   ⟹   NP_001008884
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,550,594 - 4,560,162 (-)NCBI
mRatBN7.2204,548,664 - 4,558,237 (-)NCBI
Rnor_6.0204,087,621 - 4,097,190 (+)NCBI
Rnor_5.0206,167,759 - 6,177,328 (+)NCBI
RGSC_v3.4204,671,489 - 4,681,058 (-)RGD
Celera206,150,824 - 6,160,393 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279016   ⟹   XP_063135086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,550,694 - 4,560,182 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001008884   ⟸   NM_001008884
- Peptide Label: precursor
- UniProtKB: Q9TQA6 (UniProtKB/TrEMBL),   A6JJD3 (UniProtKB/TrEMBL),   Q5M933 (UniProtKB/TrEMBL),   A0A023ILS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069704   ⟸   ENSRNOT00000080590
RefSeq Acc Id: ENSRNOP00000000522   ⟸   ENSRNOT00000000522
RefSeq Acc Id: ENSRNOP00000057075   ⟸   ENSRNOT00000060327
RefSeq Acc Id: ENSRNOP00000080217   ⟸   ENSRNOT00000113681
RefSeq Acc Id: XP_063135086   ⟸   XM_063279016
- Peptide Label: isoform X1
Protein Domains
Ig-like   Ig-like C1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18211-F1-model_v2 AlphaFold P18211 1-264 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701330
Promoter ID:EPDNEW_R11853
Type:initiation region
Name:RT1-Db1_1
Description:RT1 class II, locus Db1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,087,633 - 4,087,693EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593282 AgrOrtholog
BioCyc Gene G2FUF-4563 BioCyc
Ensembl Genes ENSRNOG00000033215 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065029200 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000522 ENTREZGENE
  ENSRNOT00000000522.9 UniProtKB/TrEMBL
  ENSRNOT00000060327.4 UniProtKB/TrEMBL
  ENSRNOT00000080091.2 UniProtKB/TrEMBL
  ENSRNOT00000080590.2 UniProtKB/TrEMBL
  ENSRNOT00000113681.1 UniProtKB/TrEMBL
  ENSRNOT00065050476 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7310949 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_a/b_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_b_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294270 UniProtKB/TrEMBL
MGC_CLONE MGC:105710 IMAGE-MGC_LOAD
NCBI Gene 294270 ENTREZGENE
PANTHER HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1 BETA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC CLASS II-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HLA-DRB1 RGD
PhenoGen RT1-Db1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033215 RatGTEx
  ENSRNOG00065029200 RatGTEx
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A023ILS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JW17_RAT UniProtKB/TrEMBL
  A0A8I5ZQ79_RAT UniProtKB/TrEMBL
  A0A8I6AEE1_RAT UniProtKB/TrEMBL
  A6JJD3 ENTREZGENE
  F1M7F9_RAT UniProtKB/TrEMBL
  HB2D_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M933 ENTREZGENE, UniProtKB/TrEMBL
  Q9TQA6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6JJD3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-12 RT1-Db1  RT1 class II, locus Db1  RT1-Db1_mapped  RT1 class II, locus Db1 (mapped)  Data merged from RGD:3480 737654 APPROVED
2006-11-20 RT1-Db1_mapped  RT1 class II, locus Db1(mapped)  RT1-Db1  RT1 class II, locus Db1  Symbol set to symbol_mapped, name set to name (mapped) 1582166 APPROVED
2006-11-20 RT1-Db1  RT1 class II, locus Db1      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-11 RT1-Db1  RT1 class II, locus Db1      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 RT1-Db1  RT1 class II, locus Db1      Symbol and Name status set to approved 70586 APPROVED