RGD Reference Report - Association between HLA-DRB1 and myasthenia gravis in a northern Han Chinese population. - Rat Genome Database

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Association between HLA-DRB1 and myasthenia gravis in a northern Han Chinese population.

Authors: Xie, YC  Qu, Y  Sun, L  Li, HF  Zhang, H  Shi, HJ  Jiang, B  Zhao, Y  Qiao, SS  Wang, SH  Wang, DX 
Citation: Xie YC, etal., J Clin Neurosci. 2011 Nov;18(11):1524-7. doi: 10.1016/j.jocn.2011.05.002. Epub 2011 Sep 15.
RGD ID: 7365051
Pubmed: PMID:21924912   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jocn.2011.05.002   (Journal Full-text)

The cause of myasthenia gravis (MG) is unknown, but it is widely believed to be an autoimmune disease occurring in genetically susceptible individuals. The human leukocyte antigen (HLA) region is considered to be the most important genetic region for MG susceptibility genes. To investigate the association between HLA-DRB1 and myasthenia gravis (MG) in a northern Han Chinese population, a polymerase chain reaction with sequence-specific oligonucleotide probe hybridization method was used to determine the HLA-DRB1 genotypes of 91 patients with MG and 171 healthy individuals. We found that the HLA-DRB1(*)09 allele was significantly more prevalent among patients with MG than among healthy controls, especially those who experienced early onset of the disease (

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myasthenia gravis susceptibilityISOHLA-DRB1 (Homo sapiens)7365051; 7365051DNA:polymorphism: :HLA-DRB1∗ more ...RGD 
myasthenia gravis susceptibilityIAGP 7365051DNA:polymorphism: :HLA-DRB1∗ more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information