RGD Reference Report - Association of the human leucocyte antigen region with susceptibility to Parkinson's disease. - Rat Genome Database

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Association of the human leucocyte antigen region with susceptibility to Parkinson's disease.

Authors: Saiki, M  Baker, A  Williams-Gray, CH  Foltynie, T  Goodman, RS  Taylor, CJ  Compston, DA  Barker, RA  Sawcer, SJ  Goris, A 
Citation: Saiki M, etal., J Neurol Neurosurg Psychiatry. 2010 Aug;81(8):890-1. Epub 2010 May 12.
RGD ID: 5147576
Pubmed: PMID:20462916   (View Abstract at PubMed)
DOI: DOI:10.1136/jnnp.2008.162883   (Journal Full-text)

OBJECTIVE: The core pathology of Parkinson's disease (PD) is a loss of the dopaminergic neurons in the nigro-striatal pathway, but this is only part of a more widespread pathological process, the nature of which is unknown. Recent data suggest a possible role for inflammation in this disease process. The Human Leucocyte Antigen (HLA) region is one of the most important genetic susceptibility factors in many immune-mediated diseases but has not been extensively investigated in PD. METHODS: The authors typed the HLA class II loci HLA-DRB1 and -DQB1 in 528 patients with Parkinson's disease and 3430 controls from the UK. RESULTS: The authors observed an association of HLA-DRB1 with susceptibility to Parkinson's disease. In particular, HLA-DRB1*03 was more common in patients compared with controls. CONCLUSIONS: These data suggest a possible role of the HLA region in susceptibility to Parkinson's disease and as such are consistent with other evidence supporting the role of an inflammatory process in the cellular loss in Parkinson's disease, especially of the nigral dopaminergic neurons.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinson's disease  ISOHLA-DRB1 (Homo sapiens)5147576; 5147576DNA:polymorphism: :HLA-DRB1*03 (human)RGD 
Parkinson's disease  IAGP 5147576DNA:polymorphism: :HLA-DRB1*03 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bradykinesia  IAGP 5147576DNA:polymorphism: :HLA-DRB1*03RGD 
Parkinsonism  IAGP 5147576DNA:polymorphism: :HLA-DRB1*03 RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information