RGD Reference Report - Immunogenetic study of sympathetic ophthalmia. - Rat Genome Database

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Immunogenetic study of sympathetic ophthalmia.

Authors: Shindo, Y  Ohno, S  Usui, M  Ideta, H  Harada, K  Masuda, H  Inoko, H 
Citation: Shindo Y, etal., Tissue Antigens. 1997 Feb;49(2):111-5.
RGD ID: 7365100
Pubmed: PMID:9062965   (View Abstract at PubMed)

Sympathetic ophthalmia (SO) is very rare but it remains one of the most intractable eye diseases. In clinical manifestations and histopathologic features SO is known to resemble closely Vogt-Koyanagi-Harada's disease (VKH disease). We had reported that VKH disease was significantly associated with HLA-DRB1*04 and -DQB1*04 in Japanese patients. In this study, to investigate an HLA association with SO we performed HLA serological and PCR-based DNA typing in 16 patients and 50 healthy controls. Our study revealed that HLA-DRB1*04 (0405; Pc < 5 x 10(-4)), DQA1*03 (Pc < 5 x 10(-3)), and DQB1*04 (0401; Pc < 5 x 10(-4)) were significantly associated with SO as compared to the healthy controls but there was no significant difference in the frequencies of any DPB1 alleles between the patients and healthy controls. It can be postulated that not only the clinical manifestations but also the genetic predisposition of SO are very similar to those of VKH disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
sympathetic ophthalmia susceptibilityISOHLA-DRB1 (Homo sapiens)7365100; 7365100DNA:polymorphism: :HLA-DRB1*04(human)RGD 
sympathetic ophthalmia susceptibilityIAGP 7365100DNA:polymorphism: :HLA-DRB1*04(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information