RGD Reference Report - The association between the HLA system and retinopathy development in patients with type 1 diabetes mellitus. - Rat Genome Database

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The association between the HLA system and retinopathy development in patients with type 1 diabetes mellitus.

Authors: Kastelan, S  Tomic, M  Salopek-Rabatic, J  Pavan, J  Lukenda, A  Gotovac, M  Zunec, R 
Citation: Kastelan S, etal., Coll Antropol. 2013 Apr;37 Suppl 1:65-70.
RGD ID: 7365113
Pubmed: PMID:23837223   (View Abstract at PubMed)

Duration of diabetes and chronic hyperglycemia are the most important risk factors in the pathogenesis of diabetic retinopathy (DR). However, there is increasing evidence suggesting that genetic factors may also contribute to its development. The aim of this study was to determine the role of the HLA system in the development of DR in patients with type 1 diabetes mellitus. Class II genes (DRB1, DQB1) were typed using the PCR-SSP method. Based on the fundus examination the patients were divided into two groups: one group with no or mild nonproliferative diabetic retinopathy (NPDR) and the other group with severe/very severe NPDR or proliferative diabetic retinopathy (PDR). The study confirms the influence of HLA genes in the development of DR in Croatian type 1 diabetic patients. In our patients, susceptibility to PDR appears to be primarily associated to DQB1*0201 with the relative risk, RR = 5.29 and DQB1*0302 (RR = 2.84). However, a strong positive correlation between DR and alles DRB1*0301 (RR = 2.12) and DRB1*0402 (RR = 3.01) was also found.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetic retinopathy susceptibilityISOHLA-DRB1 (Homo sapiens)7365113; 7365113associated with Diabetes Mellitus Type 1 more ...RGD 
diabetic retinopathy susceptibilityIAGP 7365113associated with Diabetes Mellitus Type 1 more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information