RGD Reference Report - Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis. - Rat Genome Database

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Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis.

Authors: Ward, MM  Hendrey, MR  Malley, JD  Learch, TJ  Davis JC, JR  Reveille, JD  Weisman, MH 
Citation: Ward MM, etal., Arthritis Rheum. 2009 Jul 15;61(7):859-66.
RGD ID: 5147611
Pubmed: PMID:19565552   (View Abstract at PubMed)
PMCID: PMC2710412   (View Article at PubMed Central)
DOI: DOI:10.1002/art.24585   (Journal Full-text)

OBJECTIVE: To improve prognostic ability in ankylosing spondylitis (AS), we sought to identify demographic, clinical, and immunogenetic characteristics associated with radiographic severity in a large cohort of patients. METHODS: Patients with AS for > or =20 years were enrolled in a cross-sectional study (n = 398). Pelvic and spinal radiographs were scored using the Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI-s), and radiographic severity was measured as the BASRI-s/duration of AS. Clinical factors and HLA-B, DR, DQ, and DP alleles associated with the highest quartile of the distribution of radiographic severity were identified by first using random forests and then using multivariable logistic regression modeling. Similar procedures were used to identify factors associated with the lowest quartile of radiographic severity. RESULTS: Radiographic severity (being in the top quartile of BASRI-s/duration of AS) was associated with older age at onset of AS (odds ratio [OR] 1.10 per year), male sex (OR 1.90), current smoker (OR 4.72), and the presence of HLA-B*4100 (OR 11.73), DRB1*0804 (OR 12.32), DQA1*0401 (OR 5.24), DQB1*0603 (OR 3.42), and DPB1*0202 (OR 23.36), whereas the presence of DRB1*0801 was strongly negatively associated (OR 0.03). Being in the lowest quartile of BASRI-s/duration of AS was also less likely among those with an older age at onset of AS (OR 0.94 per year), men (OR 0.28), and current smokers (OR 0.29). CONCLUSION: The accuracy of the prognosis of radiographic severity in AS is improved by knowing the age at disease onset, sex, smoking history, and the presence of HLA-B*4100, DRB1*0804, DQA1*0401, DQB1*0603, DRB1*0801, and DPB1*0202 alleles.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ankylosing spondylitis severityISOHLA-DQA1 (Homo sapiens)5147611; 5147611DNA:polymorphism:cds:HLA-DQA1*0401 (human)RGD 
ankylosing spondylitis severityISOHLA-DQB1 (Homo sapiens)5147611; 5147611DNA:polymorphism:cds:HLA-DQB1*0603 (human)RGD 
ankylosing spondylitis severityISOHLA-DRB1 (Homo sapiens)5147611; 5147611DNA:polymorphisms:cds:HLA-DRB1*0801 and HLA-DRB1*0804 (human)RGD 
ankylosing spondylitis severityIAGP 5147611DNA:polymorphism:cds:HLA-DQA1*0401 (human)RGD 
ankylosing spondylitis severityIAGP 5147611DNA:polymorphism:cds:HLA-DQB1*0603 (human)RGD 
ankylosing spondylitis severityIAGP 5147611DNA:polymorphisms:cds:HLA-DRB1*0801 and HLA-DRB1*0804 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Back pain severityIAGP 5147611DNA:polymorphism:cds:HLA-DQA1*0401RGD 
Back pain severityIAGP 5147611DNA:polymorphism:cds:HLA-DQB1*0603RGD 
Back pain severityIAGP 5147611DNA:polymorphisms:cds:HLA-DRB1*0801 and HLA-DRB1*0804RGD 
Sacroiliac arthritis severityIAGP 5147611DNA:polymorphism:cds:HLA-DQA1*0401RGD 
Sacroiliac arthritis severityIAGP 5147611DNA:polymorphism:cds:HLA-DQB1*0603RGD 
Sacroiliac arthritis severityIAGP 5147611DNA:polymorphisms:cds:HLA-DRB1*0801 and HLA-DRB1*0804RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)
RT1-Bb  (RT1 class II, locus Bb)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information