RGD Reference Report - The role of the human leukocyte antigen system in retinopathy of prematurity: a pilot study. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

The role of the human leukocyte antigen system in retinopathy of prematurity: a pilot study.

Authors: Flor-de-Lima, F  Rocha, G  Proenca, E  Tafulo, S  Freitas, F  Guimaraes, H 
Citation: Flor-de-Lima F, etal., Acta Paediatr. 2013 Aug 29. doi: 10.1111/apa.12410.
RGD ID: 7365093
Pubmed: PMID:24033735   (View Abstract at PubMed)
DOI: DOI:10.1111/apa.12410   (Journal Full-text)

AIM: To assess the association between the human leukocyte antigen system and retinopathy of prematurity. METHODS: Neonates of <32 weeks of gestational age, born at two level III neonatal intensive care units from January 2000 to December 2001 and from January 2006 to June 2009, were included in the study. Demographic and clinical data were recorded, and retinopathy was classified according to the International Classification. Epithelial cells were collected from the oral cavity and the HLA were studied using the PCR/SSO method. Univariate and multivariate analyses were performed using SPSS(R) v.18. RESULTS: We evaluated 156 neonates, including 82 (52.6%) males. Median gestational age was 29 (23-31) weeks, and median birth weight was 1030 (525-1935) grams. Seventy (44.9%) of the neonates developed retinopathy. Alleles HLA-B*38, HLA-Cw*12, HLA-DRB1*09, HLA-DRB1*14 (univariate analysis) and HLA-A*68 and HLA-Cw*12 were associated to retinopathy (multivariate analysis). CONCLUSION: The results suggest that the HLA system may be associated with the development of retinopathy of prematurity. A large-scale population-based study should be performed to clarify this association.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
retinopathy of prematurity susceptibilityISOHLA-DRB1 (Homo sapiens)7365093; 7365093DNA:polymorphism: :HLA-DRB1*09 and HLA-DRB1*14(human)RGD 
retinopathy of prematurity  ISOHLA-B (Homo sapiens)7365093; 7365093DNA:polymorphisms:cds:HLA-B*38 (human) RGD 
retinopathy of prematurity  IAGP 7365093DNA:polymorphism:cds:HLA-B*38 (human)RGD 
retinopathy of prematurity susceptibilityIAGP 7365093DNA:polymorphism: :HLA-DRB1*09 and HLA-DRB1*14(human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal retinal morphology  IAGP 7365093DNA:polymorphism:cds:HLA-B*38RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-CE13  (RT1 class I, locus CE13)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)
H2-Q4  (histocompatibility 2, Q region locus 4)

Genes (Homo sapiens)
HLA-B  (major histocompatibility complex, class I, B)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information