RGD Reference Report - Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis. - Rat Genome Database

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Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis.

Authors: Vasconcelos, CC  Fernandez, O  Leyva, L  Thuler, LC  Alvarenga, RM 
Citation: Vasconcelos CC, etal., J Neuroimmunol. 2009 Sep 29;214(1-2):101-3. Epub 2009 Jul 17.
RGD ID: 5147610
Pubmed: PMID:19616314   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2009.06.009   (Journal Full-text)

The effect of HLA alleles on the outcome of multiple sclerosis (MS) has been widely investigated; however, results are conflicting and no consistent correlation has been established. This study evaluated the association between the HLA DR2 haplotype in patients with primary progressive MS (PPMS) and the effect of alleles on progression. An association was found between PPMS and the DR2 and DRB1*1501 and DQB1*0602 alleles. Severe morbidity was found in DRB1*1501-positive PPMS patients. This exploratory study raises new hypotheses for future research and emphasizes the need to investigate possible candidate genes other than HLA that may contribute towards heterogeneity in the course of the disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
primary progressive multiple sclerosis severityISOHLA-DQB1 (Homo sapiens)5147610; 5147610DNA:polymorphism: :HLA-DQB1*0602 (human) RGD 
primary progressive multiple sclerosis severityISOHLA-DRB1 (Homo sapiens)5147610; 5147610DNA:polymorphisms more ...RGD 
primary progressive multiple sclerosis severityIAGP 5147610DNA:polymorphism: :HLA-DQB1*0602 (human) RGD 
primary progressive multiple sclerosis severityIAGP 5147610DNA:polymorphisms more ...RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal cerebrospinal fluid morphology severityIAGP 5147610DNA:polymorphism: :HLA-DQB1*0602 (human) RGD 
Abnormal cerebrospinal fluid morphology severityIAGP 5147610DNA:polymorphisms more ...RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information