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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: RT1-Db1
Name: RT1 class II, locus Db1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RT1-Db1decreases expressionEXP 6480464CTDOzone results in decreased expression of RT1-DB1 mRNAPMID:16716893
RT1-Db1decreases expressionISOH2-Eb1 (Mus musculus)6480464CTDOzone results in decreased expression of H2-EB1 mRNAPMID:12763052 PMID:20032013
RT1-Db1increases expressionISOHLA-DRB1 (Homo sapiens)6480464CTDOzone results in increased expression of HLA-DRB1 mRNAPMID:23033980
RT1-Db1multiple interactionsISOH2-Eb1 (Mus musculus)6480464CTD[[LTA gene mutant form co-treated with TNF gene mutant form co-treated with LTB gene mutant form] co-treated with Ozone] results in decreased expression of H2-EB1 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of H2-EB1 mRNA; [H2-AB1 gene mutant form co-treated with H2-AA gene mutant form co-treated with H2-EB1 gene mutant form co-treated with H2-EB2 gene mutant form co-treated with H2-EA gene mutant form] inhibits the reaction [Ozone results in increased expression of LTA mRNA]; [H2-AB1 gene mutant form co-treated with H2-AA gene mutant form co-treated with H2-EB1 gene mutant form co-treated with H2-EB2 gene mutant form co-treated with H2-EA gene mutant form] inhibits the reaction [Ozone results in increased expression of TNF mRNA]; [H2-AB1 gene mutant form co-treated with H2-AA gene mutant form co-treated with H2-EB1 gene mutant form co-treated with H2-EB2 gene mutant form co-treated with H2-EA gene mutant form] results in decreased susceptibility to Ozone; [LTA gene mutant form co-treated with Ozone] results in decreased expression of H2-EB1 mRNAPMID:20032013 PMID:34911549
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