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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: RT1-Db1
Name: RT1 class II, locus Db1
Acc ID: CHEBI:50667
Term: mercaptopurine
Definition: A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.
Chemical ID: MESH:D015122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RT1-Db1decreases expressionEXP 6480464CTDMercaptopurine results in decreased expression of RT1-DB1 mRNAPMID:23358152
RT1-Db1affects response to substanceISOHLA-DRB1 (Homo sapiens)6480464CTDHLA-DRB1 gene polymorphism affects the susceptibility to MercaptopurinePMID:25217962
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