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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:phosphatidylinositol 3-kinase-Akt signaling pathway
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Accession:PW:0000232 term browser browse the term
Definition:The phosphatidylinositol 3-kinase-Akt signaling pathway, involving PI3K class I enzymes, particularly class IA, controls various processes such as cell growth, proliferation and survival. Class IA enzymes couple to receptor tyrosine kinases or their adaptors; class IB couple to G-protein-coupled receptors mainly via Galphai. Members of the Akt family of protein kinases are activated downstream of class I PI3Ks and collectively (Akt1, 2, and 3) phosphorylate more than 70 cytoplasmic and nuclear substrates. Deregulation of the pathway has been linked to various forms of cancer.
Synonyms:related_synonym: PI3K Cascade;   PI3K-Akt signaling pathway;   PI3K/AKT Signaling;   phosphoinositide 3-kinase-Akt signaling pathway
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phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO
IMP		 PID
RGD		 PMID:17641274 PMID:27188433 PMID:17272396 PMID:12084817 PID:200197, RGD:2290458, RGD:152995510, RGD:152177689, RGD:625444 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IMP
ISO		 PID
RGD		 PMID:12089343 PMID:17641274 PID:200197, RGD:632179, RGD:2290458 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO PID
RGD		 PMID:17641274 PID:200197, RGD:2290458 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Bad BCL2-associated agonist of cell death ISO PID PID:200197 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Casp9 caspase 9 ISO PID PID:200197 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO PID PID:200197 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B ISO PID PID:200197 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200197 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ckb creatine kinase B IMP RGD PMID:17272396 RGD:152177689 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Esr1 estrogen receptor 1 IMP RGD PMID:17272396 RGD:152177689 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Foxo1 forkhead box O1 ISO PID PID:200197 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Foxo3 forkhead box O3 ISO PID PID:200197 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Foxo4 forkhead box O4 ISO PID PID:200197 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO PID PID:200197 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO PID PID:200197 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IMP RGD PMID:17272396 RGD:152177689 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200197 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO RGD PMID:17371235 RGD:2302068 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO RGD PMID:17371235 RGD:2302068 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500 		JBrowse link
G Insr insulin receptor IEP RGD PMID:29896241 PMID:25352008 RGD:14700925, RGD:14700927 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Kpna1 karyopherin subunit alpha 1 ISO PID PID:200197 NCBI chr11:64,715,844...64,774,647
Ensembl chr11:64,717,563...64,774,623 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO PID PID:200197 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapkap1 MAPK associated protein 1 ISO PID PID:200197 NCBI chr 3:17,715,813...17,918,387
Ensembl chr 3:17,715,834...17,918,384 		JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO PID PID:200197 NCBI chr10:13,498,377...13,504,128
Ensembl chr10:13,498,388...13,504,128 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO PID PID:200197 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID
RGD		 PMID:17641274 PID:200197, RGD:2290458 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pgr progesterone receptor IMP RGD PMID:17272396 RGD:152177689 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 ISO RGD PMID:24794538 RGD:11535053 NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977 		JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 ISO RGD PMID:24794538 RGD:11535053 NCBI chr19:37,835,125...37,901,804
Ensembl chr19:37,835,125...37,905,513 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO RGD PMID:17641274 PMID:27188433 RGD:2290458, RGD:152995510 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO RGD PMID:17641274 RGD:2290458 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO RGD PMID:17641274 PMID:26311905 PMID:29893841 RGD:2290458, RGD:40890274, RGD:40890270 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO
IMP		 RGD PMID:29666415 PMID:29323718 PMID:21665152 RGD:38599151, RGD:38599216, RGD:38599159 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO RGD PMID:17641274 RGD:2290458 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO RGD PMID:17641274 RGD:2290458 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO RGD PMID:17641274 RGD:2290458 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:23454242 RGD:11535052 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta ISO RGD PMID:23454242 RGD:11535052 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha ISO RGD PMID:23454242 RGD:11535052 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta ISO RGD PMID:23454242 RGD:11535052 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO RGD PMID:23454242 RGD:11535052 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO PID PID:200197 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO PID PID:200197 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:17641274 PMID:27188433 RGD:2290458, RGD:152995510 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200197 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 ISO PID PID:200197 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426 		JBrowse link
G Sfn stratifin ISO PID PID:200197 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 ISO PID PID:200197 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Sp1 Sp1 transcription factor IMP RGD PMID:17272396 RGD:152177689 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200197 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tbc1d4 TBC1 domain family, member 4 ISO PID PID:200197 NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265 		JBrowse link
G Vegfa vascular endothelial growth factor A IMP RGD PMID:17272396 RGD:152177689 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta ISO PID PID:200197 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ISO PID PID:200197 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma ISO PID PID:200197 NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827 		JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta ISO PID PID:200197 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741 		JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta ISO PID PID:200197 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta ISO PID PID:200197 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668 		JBrowse link
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:18955974 PMID:21277552 RGD:2313763, RGD:5133243 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO RGD PMID:18955974 PMID:19506583 PMID:15166380 RGD:2313763, RGD:5490965, RGD:2313408 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO RGD PMID:18955974 RGD:2313763 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO RGD PMID:18955974 PMID:19078924 PMID:20951313 PMID:21277552 RGD:2313763, RGD:4143515, RGD:5133242, RGD:5133243 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:18955974 PMID:18008377 PMID:19078924 PMID:20951313 PMID:19506583 RGD:2313763, RGD:2326139, RGD:4143515, RGD:5133242, RGD:5490965 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      kinase mediated signaling pathway 601
        serine/threonine-specific kinase mediated signaling pathway 475
          phosphatidylinositol 3-kinase-Akt signaling pathway 58
            altered phosphatidylinositol 3-kinase-Akt signaling pathway 5
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      signaling pathway involving second messengers 358
        phosphatidylinositol 3-kinase signaling pathway 153
          phosphatidylinositol 3-kinase class I signaling pathway 91
            phosphatidylinositol 3-kinase-Akt signaling pathway 58
              altered phosphatidylinositol 3-kinase-Akt signaling pathway 5
paths to the root