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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Enterobacteriaceae Infections
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Accession:DOID:9003491 term browser browse the term
Definition:Infections with bacteria of the family ENTEROBACTERIACEAE.
Synonyms:exact_synonym: Enterobacteriaceae Infection;   Enterobacterial Infection;   Enterobacterial Infections
 primary_id: MESH:D004756
 xref: EFO:1001313


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Enterobacteriaceae Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf3 colony stimulating factor 3 IEP RGD PMID:9835289 RGD:11039473 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Fgf7 fibroblast growth factor 7 ISO mRNA:increased expression:distal colon (mouse) RGD PMID:10338516 RGD:126928149 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
Escherichia Coli Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24498193 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 IEP mRNA:increased expression:brain RGD PMID:16238536 RGD:5683919 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 treatment ISO RGD PMID:18786935 RGD:10449443 NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 treatment ISO RGD PMID:18786935 RGD:10449443 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hba-a3 hemoglobin alpha, adult chain 3 treatment ISO RGD PMID:18786935 RGD:10449443 NCBI chr10:15,311,637...15,312,481
Ensembl chr10:15,311,634...15,312,481 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 treatment ISO RGD PMID:27832756 RGD:34888235 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Lcn2 lipocalin 2 exacerbates ISO protein:increased expression:serum RGD PMID:25234944 PMID:16446425 PMID:25234944 RGD:126725084, RGD:126779557, RGD:126725084 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming IEP RGD PMID:23798529 RGD:7349358 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 onset IEP protein:decreased expression:hippocampus RGD PMID:21411668 RGD:5684914 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Plac8 placenta associated 8 severity ISO RGD PMID:17404296 RGD:40924563 NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264 		JBrowse link
G Rnasel ribonuclease L severity ISO RGD PMID:19075243 RGD:40902812 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO RGD PMID:19747920 RGD:36947380 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Tnf tumor necrosis factor IEP protein:increased expression:serum (rat) RGD PMID:9466473 RGD:38508904 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Escherichia Coli Meningitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr2 toll-like receptor 2 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr7 toll-like receptor 7 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
Klebsiella Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E severity ISO RGD PMID:10998083 RGD:11039489 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Il6 interleukin 6 treatment IDA RGD PMID:8432613 RGD:11062093 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tlr9 toll-like receptor 9 ISO RGD PMID:17785831 RGD:5130866 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
Klebsiella pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha severity ISO RGD PMID:16157683 RGD:39457940 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 severity ISO mRNA:increased expression:lung (mouse) RGD PMID:22729155 PMID:20864681 RGD:35316077, RGD:36049798 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Lcn2 lipocalin 2 exacerbates
ameliorates		 ISO protein:increased expression:lung
protein:increased expression:serum		 RGD PMID:29633303 PMID:19342674 PMID:19342674 PMID:19342674 PMID:25234944 More... RGD:126725082, RGD:126725085, RGD:126725085, RGD:126725085, RGD:126725084, RGD:126725084 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Plac8 placenta associated 8 severity ISO RGD PMID:17404296 RGD:40924563 NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 disease_progression ISO RGD PMID:24396044 RGD:126925976 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203 		JBrowse link
plague term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr5 C-C motif chemokine receptor 5 resistance IAGP DNA:polymorphism:cds:p.H184R (rat) RGD PMID:18703167 RGD:4890425 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO RGD PMID:21356370 RGD:5134954 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Fpr1 formyl peptide receptor 1 ISO ClinVar Annotator: match by term: N-FORMYLPEPTIDE RECEPTOR POLYMORPHISM ClinVar PMID:28492532 PMID:31534221 NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559 		JBrowse link
G Il17a interleukin 17A IEP mRNA,protein:increased expression:lymph node RGD PMID:20876291 RGD:4781452 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:20565713 RGD:4142820 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mavs mitochondrial antiviral signaling protein susceptibility ISO RGD PMID:25064677 RGD:40903046 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
rhinoscleroma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Ba RT1 class II, locus Ba susceptibility ISO DNA:haplotype: : RGD PMID:17321882 RGD:8547664 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744 		JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility ISO DNA:haplotype: : RGD PMID:17321882 RGD:8547664 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
Salmonella Infections, Animal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific ISO mRNA:splice variant:liver (mouse) RGD PMID:12228285 RGD:125097511 NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282 		JBrowse link
G Ahr aryl hydrocarbon receptor severity ISO RGD PMID:24930766 RGD:39939032 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aicda activation-induced cytidine deaminase severity ISO RGD PMID:29743315 RGD:127285640 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Ank1 ankyrin 1 ISO RGD PMID:23390527 RGD:11041609 NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759 		JBrowse link
G Hamp hepcidin antimicrobial peptide ISO RGD PMID:23390527 RGD:11041609 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 susceptibility ISO RGD PMID:24930766 RGD:39939032 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:16002714 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO RGD PMID:14734525 RGD:5684962 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Tlr5 toll-like receptor 5 IEP mRNA, protein:increased expression:jejunum, colon (rat) RGD PMID:20529359 RGD:5129497 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
salmonellosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coq7 coenzyme Q7, hydroxylase susceptibility ISO RGD PMID:23166727 RGD:10402105 NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158 		JBrowse link
G Il12b interleukin 12B susceptibility ISO disseminated BCG and Salmonella enteritidis infection, OMIM:209950 RGD PMID:9854038 RGD:1600042 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
shigellosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor treatment ISO RGD PMID:30615126 RGD:39938959 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:30615126 RGD:39938959 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:30615126 RGD:39938959 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B treatment ISO RGD PMID:30615126 RGD:39938959 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta treatment ISO RGD PMID:30615126 RGD:39938959 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
typhoid fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator susceptibility ISO DNA:repeats: :CA repeats(human) RGD PMID:16078047 RGD:35673348 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Lta lymphotoxin alpha susceptibility ISO DNA:SNP:: RGD PMID:11120931 RGD:36049756 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility ISO DNA:polymorphisms:: RGD PMID:11120931 RGD:36049756 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :HLA-DRB1*04:05, rs7765379(human)
DNA:polymorphisms::		 CTD
RGD		 PMID:25383971 PMID:25383971 PMID:11120931 RGD:36174025, RGD:36049756 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:25667264 RGD:11061268 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor susceptibility ISO DNA:SNP:promoter:-308G>A (rs1800629) (human) RGD PMID:11120931 RGD:36049756 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    disease by infectious agent 2215
      Bacterial Infections and Mycoses 1073
        bacterial infectious disease 824
          Gram-Negative Bacterial Infections 200
            Enterobacteriaceae Infections 47
              Escherichia Coli Infections + 16
              Klebsiella Infections + 10
              Proteus Infections 0
              Serratia Infections 0
              Yersinia Infections + 6
              granuloma inguinale + 0
              salmonellosis + 17
              shigellosis 5
paths to the root