RGD Reference Report - CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar. - Rat Genome Database

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CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar.

Authors: Tollenaere, C  Rahalison, L  Ranjalahy, M  Rahelinirina, S  Duplantier, JM  Brouat, C 
Citation: Tollenaere C, etal., Infect Genet Evol. 2008 Dec;8(6):891-7. Epub 2008 Jul 25.
RGD ID: 4890425
Pubmed: PMID:18703167   (View Abstract at PubMed)
DOI: DOI:10.1016/j.meegid.2008.07.005   (Journal Full-text)

Madagascar remains one of the world's largest plague foci. The black rat, Rattus rattus, is the main reservoir of plague in rural areas. This species is highly susceptible to plague in plague-free areas (low-altitude regions), whereas rats from the plague focus areas (central highlands) have evolved a disease-resistance polymorphism. We used the candidate gene CCR5 to investigate the genetic basis of plague resistance in R. rattus. We found a unique non-synonymous substitution (H184R) in a functionally important region of the gene. We then compared (i) CCR5 genotypes of dying and surviving plague-challenged rats and (ii) CCR5 allelic frequencies in plague focus and plague-free populations. Our results suggested a higher prevalence of the substitution in resistant animals compared to susceptible individuals, and a tendency for higher frequencies in plague focus areas compared to plague-free areas. Therefore, the CCR5 polymorphism may be involved in Malagasy black rat plague resistance. CCR5 and other undetermined plague resistance markers may provide useful biological information about host evolution and disease dynamics.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
plague resistanceISOCcr5 (Rattus norvegicus)4890425; 4890425DNA:polymorphism:cds:p.H184R (rat)RGD 
plague resistanceIAGP 4890425DNA:polymorphism:cds:p.H184R (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR5  (C-C motif chemokine receptor 5)


Additional Information