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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1318853 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IRAK3 mRNA | CTD | PMID:22079256 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of IRAK3 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1318854 | 6480464 | Tetrachlorodibenzodioxin affects the expression of IRAK3 mRNA | CTD | PMID:21570461 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1318854 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of IRAK3 mRNA | CTD | PMID:19191707 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of IRAK3 mRNA | CTD | PMID:20488242 | arsenite(3-) | increases expression | ISO | RGD:1318854 | 6480464 | arsenite results in increased expression of IRAK3 mRNA | CTD | PMID:18191166 | benzo[a]pyrene | increases expression | ISO | RGD:1318854 | 6480464 | Benzo(a)pyrene results in increased expression of IRAK3 mRNA | CTD | PMID:22228805 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:1318854 | 6480464 | Mustard Gas results in increased expression of IRAK3 mRNA | CTD | PMID:18955075 | choline | multiple interactions | ISO | RGD:1318854 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IRAK3 mRNA | CTD | PMID:20938992 | diazoxide | increases expression | ISO | RGD:1318854 | 6480464 | Isoproterenol results in increased expression of IRAK3 mRNA | CTD | PMID:20003209 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of IRAK3 mRNA | CTD | PMID:21551480 | folic acid | multiple interactions | ISO | RGD:1318854 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IRAK3 mRNA | CTD | PMID:20938992 | hyaluronic acid | increases expression | ISO | RGD:1318853 | 6480464 | Hyaluronic Acid results in increased expression of IRAK3 protein | CTD | PMID:15728517 | isoprenaline | increases expression | ISO | RGD:1318854 | 6480464 | Isoproterenol results in increased expression of IRAK3 mRNA | CTD | PMID:20003209 | L-methionine | multiple interactions | ISO | RGD:1318854 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IRAK3 mRNA | CTD | PMID:20938992 | paracetamol | decreases expression | ISO | RGD:1318853 | 6480464 | Acetaminophen results in decreased expression of IRAK3 mRNA | CTD | PMID:22230336 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:1318853 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IRAK3 mRNA | CTD | PMID:16979875 | pirinixic acid | multiple interactions | ISO | RGD:1318854 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IRAK3 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | RGD:1318854 | 6480464 | pirinixic acid results in increased expression of IRAK3 mRNA | CTD | PMID:20813756 | progesterone | increases expression | ISO | RGD:1318853 | 6480464 | Progesterone results in increased expression of IRAK3 mRNA | CTD | PMID:17404688 | zinc atom | multiple interactions | ISO | RGD:1318853 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IRAK3 mRNA | CTD | PMID:16979875 | zinc(0) | multiple interactions | ISO | RGD:1318853 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IRAK3 mRNA | CTD | PMID:16979875 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Apoptosis |
| Neurotrophin signaling pathway | |
| Pathway Interaction Database | IL1-mediated signaling events (PID:200089) |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Apoptosis |
| Neurotrophin signaling pathway | |
| Pathway Interaction Database | IL1-mediated signaling events (PID:200089) |
References - curated| 1. |
GOA data from the GO Consortium |
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MGD data from the GO Consortium |
| 3. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
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RGD automated import pipeline for gene-chemical interactions |
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RGD Automated Pipelines |
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RGD comprehensive gene curation |
References - uncurated
RGD Disease Portals| Irak3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Irak3 (Rattus norvegicus) |
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| IRAK3 (Homo sapiens) |
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| Irak3 (Mus musculus) |
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Position Markers| RH141464 |
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| RH133525 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001108101 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06050010 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01049561 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01049562 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01049563 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC166731 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473960 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001108101 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001101571 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001101571 | (Get FASTA) |
| GenBank Protein | AAI66731 | (Get FASTA) |
| EDM16573 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000004226 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000005686 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000005686 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 314870 | ENTREZGENE |
| Gene3D-CATH | DEATH_like | UniProtKB/TrEMBL |
| HomoloGene Group ID | 36215 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7934689 | IMAGE-MGC_LOAD |
| InterPro | Death | UniProtKB/TrEMBL |
| DEATH-like | UniProtKB/TrEMBL | |
| Kinase-like_dom | UniProtKB/TrEMBL | |
| Prot_kinase_cat_dom | UniProtKB/TrEMBL | |
| IPI | IPI00870270 | UniProtKB/TrEMBL |
| KEGG Report | rno:314870 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:188449 | IMAGE-MGC_LOAD |
| Pfam | Death | UniProtKB/TrEMBL |
| Pkinase | UniProtKB/TrEMBL | |
| PROSITE | DEATH_DOMAIN | UniProtKB/TrEMBL |
| PROTEIN_KINASE_DOM | UniProtKB/TrEMBL | |
| Superfamily-SCOP | DEATH_like | UniProtKB/TrEMBL |
| Kinase_like | UniProtKB/TrEMBL | |
| UniGene | Rn.147737 | ENTREZGENE |
| UniProt | B2RYC8_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-04-30 | Irak3 | interleukin-1 receptor-associated kinase 3 | Irak3_predicted | interleukin-1 receptor-associated kinase 3 (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Irak3_predicted | interleukin-1 receptor-associated kinase 3 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Irak3 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1308846 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




