ONTOLOGY REPORT - ANNOTATIONS

Term:dobutamine
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Accession:CHEBI:4670 term browser browse the term
Definition:4-(3-Aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.
Synonyms:exact_synonym: 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
 related_synonym: (+-)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol;   3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine;   4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol;   C18H23NO3;   CC(CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1;   DL-dobutamine;   InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3;   InChIKey=JRWZLRBJNMZMFE-UHFFFAOYSA-N;   dobutamina;   dobutaminum;   rac-dobutamine;   racemic-dobutamine
 alt_id: CHEBI:184505;   CHEBI:554519
 xref_casrn: 34368-04-2
 xref: Beilstein:2946389 "Beilstein Registry Number";   ChEMBL:184505 "ChEMBL COMPOUND";   ChEMBL:554519 "ChEMBL COMPOUND";   ChemIDplus:34368-04-2 "CAS Registry Number";   CiteXplore:11280019 "PubMed citation";   CiteXplore:11950781 "PubMed citation";   CiteXplore:18323735 "PubMed citation";   CiteXplore:22537238 "PubMed citation";   DrugBank:DB00841 "DrugBank";   KEGG COMPOUND:34368-04-2 "CAS Registry Number";   KEGG COMPOUND:C06967 "KEGG COMPOUND";   KEGG DRUG:D03879 "KEGG DRUG"
 xref_mesh: MESH:D004280
 xref: Patent:DE2317710 "Patent";   Patent:US3987200 "Patent";   Reaxys:2946389 "Reaxys Registry Number";   Wikipedia:Dobutamine "Wikipedia"

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dobutamine term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Adcy6 adenylate cyclase 6 GBrowse link affects response to substance ISO 7 137,339,933 137,360,020 RGD:6480464 CTD
G Adra2a adrenoceptor alpha 2A multiple interactions ISO RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link affects response to substance ISO 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link multiple interactions ISO 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link multiple interactions ISO 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link multiple interactions ISO 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link affects response to substance ISO 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link multiple interactions EXP 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link multiple interactions EXP 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link multiple interactions EXP 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link multiple interactions ISO 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link multiple interactions ISO 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb1 adrenoceptor beta 1 GBrowse link affects response to substance ISO 1 263,025,655 263,027,055 RGD:6480464 CTD
G Adrb2 adrenoceptor beta 2, surface GBrowse link affects response to substance ISO 18 58,174,958 58,177,000 RGD:6480464 CTD
G Adrb3 adrenoceptor beta 3 GBrowse link multiple interactions EXP 16 69,163,620 69,166,384 RGD:6480464 CTD
G Ahsg alpha-2-HS-glycoprotein GBrowse link affects response to substance ISO 11 80,330,615 80,336,658 RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link affects response to substance ISO 6 137,640,482 137,657,552 RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link multiple interactions EXP 6 137,640,482 137,657,552 RGD:6480464 CTD
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link multiple interactions EXP 1 82,686,233 82,726,544 RGD:6480464 CTD
G Akt3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) GBrowse link multiple interactions EXP 13 92,802,390 93,110,704 RGD:6480464 CTD
G Arrb1 arrestin, beta 1 GBrowse link multiple interactions ISO 1 156,871,564 156,937,540 RGD:6480464 CTD
G Arrb2 arrestin, beta 2 GBrowse link multiple interactions ISO 10 57,244,071 57,284,166 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link increases expression ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link decreases expression ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bnip1 BCL2/adenovirus E1B interacting protein 1 GBrowse link increases expression ISO 10 16,648,619 16,660,896 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link multiple interactions ISO 10 70,256,263 70,258,061 RGD:6480464 CTD
G Ccl3 chemokine (C-C motif) ligand 3 GBrowse link multiple interactions ISO 10 71,744,559 71,746,109 RGD:6480464 CTD
G Clu clusterin GBrowse link increases expression ISO 15 45,365,779 45,405,314 RGD:6480464 CTD
G Comt catechol-O-methyltransferase GBrowse link increases methylation ISO 11 84,561,591 84,581,713 RGD:6480464 CTD
G Comt catechol-O-methyltransferase GBrowse link increases expression EXP 11 84,561,591 84,581,713 RGD:6480464 CTD
G Cpt1a carnitine palmitoyltransferase 1a, liver GBrowse link increases expression EXP 1 205,852,800 205,912,972 RGD:6480464 CTD
G Crem cAMP responsive element modulator GBrowse link affects response to substance ISO 17 62,770,633 62,837,670 RGD:6480464 CTD
G Ctf1 cardiotrophin 1 GBrowse link affects response to substance ISO 1 187,001,445 187,006,655 RGD:6480464 CTD
G Cxcl2 chemokine (C-X-C motif) ligand 2 GBrowse link multiple interactions ISO 14 18,677,129 18,679,175 RGD:6480464 CTD
G Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) GBrowse link affects response to substance ISO 3 6,052,706 6,069,826 RGD:6480464 CTD
G Dmd dystrophin GBrowse link increases response to substance ISO X 71,501,362 71,671,414 RGD:6480464 CTD
G Egfr epidermal growth factor receptor GBrowse link decreases response to substance ISO 14 97,617,358 97,788,211 RGD:6480464 CTD
G Egfr epidermal growth factor receptor GBrowse link multiple interactions ISO 14 97,617,358 97,788,211 RGD:6480464 CTD
G F3 coagulation factor III (thromboplastin, tissue factor) GBrowse link increases expression ISO 2 218,371,050 218,382,645 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link affects response to substance ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link affects response to substance ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Fos FBJ osteosarcoma oncogene GBrowse link multiple interactions EXP 6 109,559,135 109,562,001 RGD:6480464 CTD
G G6pd glucose-6-phosphate dehydrogenase GBrowse link increases activity EXP X 160,186,450 160,192,316 RGD:6480464 CTD
G Gh1 growth hormone 1 GBrowse link multiple interactions EXP 10 95,692,240 95,694,117 RGD:6480464 CTD
G Gk glycerol kinase GBrowse link increases activity EXP X 72,416,872 72,493,296 RGD:6480464 CTD
G Gnas GNAS complex locus GBrowse link increases response to substance ISO 3 165,213,399 165,214,551 RGD:6480464 CTD
G Gsk3b glycogen synthase kinase 3 beta GBrowse link affects response to substance ISO 11 64,284,731 64,428,698 RGD:6480464 CTD
G Hbegf heparin-binding EGF-like growth factor GBrowse link multiple interactions ISO 18 29,143,567 29,153,944 RGD:6480464 CTD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link increases expression EXP 19 13,963,139 13,969,960 RGD:6480464 CTD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link increases expression EXP 19 13,963,139 13,969,960 RGD:6480464 CTD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link multiple interactions EXP 19 13,963,139 13,969,960 RGD:6480464 CTD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link multiple interactions EXP 19 13,963,139 13,969,960 RGD:6480464 CTD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link increases expression EXP 19 13,963,139 13,969,960 RGD:6480464 CTD
G Igf1 insulin-like growth factor 1 GBrowse link increases response to substance EXP 7 24,531,669 24,605,742 RGD:6480464 CTD
G Il10 interleukin 10 GBrowse link multiple interactions ISO 13 43,953,900 43,957,766 RGD:6480464 CTD
G Il10 interleukin 10 GBrowse link multiple interactions ISO 13 43,953,900 43,957,766 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link increases expression EXP 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link increases expression ISO 4 456,799 461,376 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link multiple interactions ISO 4 456,799 461,376 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link decreases expression EXP 4 456,799 461,376 RGD:6480464 CTD
G Itgb1 integrin, beta 1 GBrowse link affects response to substance ISO 19 58,600,095 58,647,531 RGD:6480464 CTD
G Jun jun proto-oncogene GBrowse link multiple interactions EXP 5 115,358,166 115,361,259 RGD:6480464 CTD
G Jund jun D proto-oncogene GBrowse link multiple interactions EXP 16 19,239,694 19,241,529 RGD:6480464 CTD
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 GBrowse link multiple interactions ISO 1 96,614,960 96,617,993 RGD:6480464 CTD
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 GBrowse link affects response to substance ISO 1 96,614,960 96,617,993 RGD:6480464 CTD
G Klk1 kallikrein 1 GBrowse link affects response to substance ISO 1 94,624,828 94,628,822 RGD:6480464 CTD
G Lep leptin GBrowse link decreases secretion ISO 4 55,943,837 55,945,938 RGD:6480464 CTD
G Lep leptin GBrowse link decreases expression ISO 4 55,943,837 55,945,938 RGD:6480464 CTD
G Lepr leptin receptor GBrowse link affects response to substance ISO 5 122,320,075 122,503,449 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link multiple interactions EXP 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link increases phosphorylation EXP 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link multiple interactions ISO 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link multiple interactions EXP 1 185,935,044 185,941,245 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link increases phosphorylation EXP 1 185,935,044 185,941,245 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link multiple interactions ISO 1 185,935,044 185,941,245 RGD:6480464 CTD
G Mapk9 mitogen-activated protein kinase 9 GBrowse link multiple interactions EXP 10 35,353,486 35,384,319 RGD:6480464 CTD
G Mb myoglobin GBrowse link affects response to substance ISO 7 115,087,558 115,094,789 RGD:6480464 CTD
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link multiple interactions ISO 6 75,729,302 75,732,475 RGD:6480464 CTD
G Nos1 nitric oxide synthase 1, neuronal GBrowse link affects response to substance ISO 12 39,812,500 39,869,484 RGD:6480464 CTD
G Nos2 nitric oxide synthase 2, inducible GBrowse link affects response to substance ISO 10 65,036,884 65,072,453 RGD:6480464 CTD
G Nos2 nitric oxide synthase 2, inducible GBrowse link affects response to substance ISO 10 65,036,884 65,072,453 RGD:6480464 CTD
G Phgdh phosphoglycerate dehydrogenase GBrowse link increases expression EXP 2 193,147,943 193,177,137 RGD:6480464 CTD
G Pln phospholamban GBrowse link affects response to substance ISO 20 32,000,371 32,008,559 RGD:6480464 CTD
G Ppp2ca protein phosphatase 2, catalytic subunit, alpha isozyme GBrowse link affects response to substance ISO 10 37,621,256 37,641,008 RGD:6480464 CTD
G Prkaca protein kinase, cAMP-dependent, catalytic, alpha GBrowse link multiple interactions EXP 19 25,840,795 25,864,786 RGD:6480464 CTD
G Prkce protein kinase C, epsilon GBrowse link affects response to substance ISO 6 9,631,234 10,097,311 RGD:6480464 CTD
G Prop1 PROP paired-like homeobox 1 GBrowse link decreases response to substance ISO 10 36,527,112 36,529,573 RGD:6480464 CTD
G Ren renin GBrowse link multiple interactions ISO 13 46,262,936 46,275,213 RGD:6480464 CTD
G Ren renin GBrowse link increases activity ISO 13 46,262,936 46,275,213 RGD:6480464 CTD
G Ren renin GBrowse link increases secretion ISO 13 46,262,936 46,275,213 RGD:6480464 CTD
G Ren renin GBrowse link increases expression ISO 13 46,262,936 46,275,213 RGD:6480464 CTD
G S100a1 S100 calcium binding protein A1 GBrowse link increases response to substance ISO 2 182,784,818 182,787,370 RGD:6480464 CTD
G Scnn1g sodium channel, nonvoltage-gated 1, gamma GBrowse link increases expression EXP 1 180,555,660 180,589,534 RGD:6480464 CTD
G Sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) GBrowse link affects response to substance ISO 10 32,084,678 32,489,330 RGD:6480464 CTD
G Sptan1 spectrin, alpha, non-erythrocytic 1 GBrowse link increases degradation EXP 3 8,956,380 9,021,831 RGD:6480464 CTD
G Tac1 tachykinin, precursor 1 GBrowse link multiple interactions ISO 4 32,649,666 32,657,632 RGD:6480464 CTD
G Tacr1 tachykinin receptor 1 GBrowse link multiple interactions ISO 4 116,610,595 116,780,394 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link increases expression EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb2 transforming growth factor, beta 2 GBrowse link increases expression EXP 13 102,718,703 102,818,768 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases secretion EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Usf1 upstream transcription factor 1 GBrowse link multiple interactions ISO 13 87,336,705 87,344,466 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link affects response to substance ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link affects response to substance ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link affects response to substance ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      biological role 480454
        molecular messenger 58036
          monoamine molecular messenger 1096
            catecholamine 944
              dobutamine 105
                (R)-dobutamine 0
                (S)-dobutamine 0
                dobutamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    main group molecular entity 456122
                      s-block molecular entity 310368
                        hydrogen molecular entity 307614
                          hydrides 192538
                            inorganic hydride 82328
                              pnictogen hydride 80801
                                nitrogen hydride 80796
                                  azane 75037
                                    ammonia 74849
                                      organic amino compound 74788
                                        aralkylamino compound 1823
                                          monoamine 1096
                                            monoamine molecular messenger 1096
                                              catecholamine 944
                                                dobutamine 105
                                                  (R)-dobutamine 0
                                                  (S)-dobutamine 0
                                                  dobutamine hydrochloride 0
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