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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2056
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra2a
Name: adrenoceptor alpha 2A
Acc ID: CHEBI:4670
Term: dobutamine
Definition: A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.
Chemical ID: MESH:D004280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra2amultiple interactionsISOADRA2A (Homo sapiens)6480464CTDDobutamine binds to and results in increased activity of ADRA2A proteinPMID:16024912
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