1. |
A syndrome of congenital hyperinsulinism and rhabdomyolysis is caused by KCNJ11 mutation. |
Albaqumi M, etal., J Med Genet. 2014 Apr;51(4):271-4. doi: 10.1136/jmedgenet-2013-102085. Epub 2014 Jan 13.
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2. |
Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits. |
Bao L, etal., Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H262-70. doi: 10.1152/ajpheart.00857.2010. Epub 2010 Oct 22.
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3. |
Identification of two novel frameshift mutations in the KCNJ11 gene in two Italian patients affected by Congenital Hyperinsulinism of Infancy. |
Biagiotti L, etal., Exp Mol Pathol. 2007 Aug;83(1):59-64. Epub 2007 Jan 17.
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4. |
KATP channel conductance of descending vasa recta pericytes. |
Cao C, etal., Am J Physiol Renal Physiol. 2005 Dec;289(6):F1235-45. Epub 2005 Jul 26.
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5. |
Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles. |
Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9.
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6. |
Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. |
Cooper PE, etal., J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.
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7. |
An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1. |
Craig TJ, etal., J Clin Endocrinol Metab. 2009 Jul;94(7):2551-7. Epub 2009 Apr 7.
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8. |
Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts. |
Cuong DV, etal., Mitochondrion. 2005 Apr;5(2):121-33.
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9. |
The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function. |
Dhar-Chowdhury P, etal., J Biol Chem. 2005 Nov 18;280(46):38464-70. Epub 2005 Sep 16.
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10. |
Congenital hyperinsulinism: clinical and molecular analysis of a large Italian cohort. |
Faletra F, etal., Gene. 2013 May 25;521(1):160-5. doi: 10.1016/j.gene.2013.03.021. Epub 2013 Mar 16.
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11. |
Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. |
Florez JC, etal., Diabetes. 2007 Feb;56(2):531-6.
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12. |
Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca(2+) transport in Goto-Kakizaki type 2 diabetic rat heart. |
Gaber EM, etal., Exp Physiol. 2014 Jun;99(6):881-93. doi: 10.1113/expphysiol.2013.077594. Epub 2014 Mar 28.
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13. |
Iptakalim, opener of K(ATP), reverses the enhanced expression of genes encoding K(ATP) subunits in spontaneously hypertensive rats. |
Gao M, etal., Life Sci. 2005 Oct 14;77(22):2743-51.
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14. |
Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes. |
Garg V, etal., Cardiovasc Res. 2009 Apr 1;82(1):51-8. doi: 10.1093/cvr/cvp039. Epub 2009 Jan 30.
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15. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
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16. |
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. |
Girard CA, etal., J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.
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17. |
KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. |
Gloyn AL, etal., Eur J Hum Genet. 2006 Jul;14(7):824-30. Epub 2006 May 3.
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18. |
Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism. |
Gloyn AL, etal., Hum Mutat. 2006 Mar;27(3):220-31.
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19. |
Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. |
Gloyn AL, etal., J Clin Endocrinol Metab. 2004 Aug;89(8):3932-5.
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20. |
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. |
Gloyn AL, etal., N Engl J Med. 2004 Apr 29;350(18):1838-49.
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21. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
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22. |
Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats. |
Gyte A, etal., J Neuroendocrinol. 2007 Dec;19(12):941-51.
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23. |
Channel regulation of glucose sensing in the pancreatic beta-cell. |
Hiriart M and Aguilar-Bryan L, Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1298-306. Epub 2008 Oct 21.
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24. |
Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk. |
Hong M, etal., J Biol Chem. 2012 Nov 30;287(49):41258-67. doi: 10.1074/jbc.M112.412122. Epub 2012 Oct 12.
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25. |
Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. |
Hu X, etal., Circ Res. 2008 Oct 24;103(9):1009-17. doi: 10.1161/CIRCRESAHA.107.170795. Epub 2008 Sep 18.
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26. |
Pregabalin attenuates excitotoxicity in diabetes. |
Huang CW, etal., PLoS One. 2013 Jun 13;8(6):e65154. doi: 10.1371/journal.pone.0065154. Print 2013.
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27. |
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. |
Inagaki N, etal., Neuron. 1996 May;16(5):1011-7.
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28. |
Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure. |
Isidoro Tavares N, etal., Cardiovasc Res. 2009 Sep 1;83(4):726-36. doi: 10.1093/cvr/cvp162. Epub 2009 May 21.
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29. |
The pattern of ATP-sensitive K+ channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats. |
Jiang K, etal., Neuropathology. 2007 Dec;27(6):531-8.
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30. |
Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. |
Kline CF, etal., Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16669-74. doi: 10.1073/pnas.0907138106. Epub 2009 Sep 15.
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31. |
Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells. |
Lim A, etal., Diabetes. 2009 Dec;58(12):2813-9. doi: 10.2337/db09-0600. Epub 2009 Aug 31.
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32. |
Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge. |
Lodwick D, etal., Biochem J. 2014 Dec 15;464(3):343-54. doi: 10.1042/BJ20140273.
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33. |
Detection of K(ATP) channels subunits in human term placental explants and evaluation of their implication in human placental lactogen (hPL) and human chorionic gonadotropin (hCG) release. |
Lybaert P, etal., Placenta. 2013 Jun;34(6):467-73. doi: 10.1016/j.placenta.2013.03.006. Epub 2013 Apr 13.
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34. |
Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function. |
Marthinet E, etal., J Clin Endocrinol Metab. 2005 Sep;90(9):5401-6. Epub 2005 Jul 5.
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35. |
A role for ATP-sensitive potassium channels in male sexual behavior. |
McDevitt MA, etal., Horm Behav. 2009 Feb;55(2):366-74. Epub 2008 Sep 16.
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36. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
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37. |
Clinical and genetic evaluation of patients with KATP channel mutations from the German registry for congenital hyperinsulinism. |
Mohnike K, etal., Horm Res Paediatr. 2014;81(3):156-68. doi: 10.1159/000356905. Epub 2014 Jan 7.
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38. |
Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells. |
Moritz W, etal., Endocrinology 2001 Jan;142(1):129-38.
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39. |
Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. |
Morrissey A, etal., BMC Physiol. 2005 Jan 12;5(1):1.
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40. |
Electronic Transfer of LocusLink and RefSeq Data |
NCBI rat LocusLink and RefSeq merged data July 26, 2002
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41. |
OMIM Disease Annotation Pipeline |
OMIM Disease Annotation Pipeline
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42. |
KEGG Annotation Import Pipeline |
Pipeline to import KEGG annotations from KEGG into RGD
|
43. |
PID Annotation Import Pipeline |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
|
44. |
SMPDB Annotation Import Pipeline |
Pipeline to import SMPDB annotations from SMPDB into RGD
|
45. |
Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. |
Rainbow RD, etal., Biochem J. 2004 Apr 1;379(Pt 1):173-81.
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46. |
GOA pipeline |
RGD automated data pipeline
|
47. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
|
48. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
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49. |
Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes. |
Riedel MJ, etal., Hum Genet. 2005 Feb;116(3):133-45. Epub 2004 Nov 23.
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50. |
Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. |
Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
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51. |
Chronic nicotine induces hypoxia inducible factor-2alpha in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. |
Salman S, etal., Am J Physiol Cell Physiol. 2012 May 15;302(10):C1531-8. doi: 10.1152/ajpcell.00052.2012. Epub 2012 Mar 7.
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52. |
Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney. |
Shimizu S, etal., Br J Pharmacol. 2011 May;163(2):272-82. doi: 10.1111/j.1476-5381.2011.01231.x.
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53. |
Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes. |
Singh H, etal., J Mol Cell Cardiol. 2003 May;35(5):445-59.
|
54. |
Genetic analysis of Italian patients with congenital hyperinsulinism of infancy. |
Sogno Valin P, etal., Horm Res Paediatr. 2013;79(4):236-42. doi: 10.1159/000350827. Epub 2013 May 1.
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55. |
Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures. |
Soundarapandian MM, etal., J Neurochem. 2007 Dec;103(5):1982-8. doi: 10.1111/j.1471-4159.2007.04883.x. Epub 2007 Sep 18.
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56. |
Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes with Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5 327 Non-diabetic Finnish Men. |
Stancakova A, etal., Diabetes. 2009 Jun 5.
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57. |
Role for SUR2A in coupling cardiac K(ATP) channels to caveolin-3. |
Sun W and Hu K, Cell Physiol Biochem. 2010;25(4-5):409-18. doi: 10.1159/000303045. Epub 2010 Mar 23.
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58. |
Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release. |
Tagmose TM, etal., J Med Chem. 2004 Jun 3;47(12):3202-11.
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59. |
Tentative Sequence Identification Numbers |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
|
60. |
Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. |
Tokuyama Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):532-8.
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61. |
The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel. |
Wan TC, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):234-43. Epub 2007 Sep 28.
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62. |
Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease? |
Wang S, etal., Neuropharmacology. 2005 Jun;48(7):984-92.
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63. |
Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia. |
Wang W, etal., J Tradit Chin Med. 2015 Oct;35(5):577-82.
|
64. |
Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes. |
Wu SN, etal., Life Sci. 2007 Jan 2;80(4):378-87. Epub 2006 Oct 17.
|
65. |
Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex. |
Yan FF, etal., Mol Biol Cell. 2010 Jun 15;21(12):1945-54. Epub 2010 Apr 28.
|
66. |
Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury. |
Yin XF, etal., Eur Neurol. 2007;57(1):4-10. Epub 2006 Nov 14.
|
67. |
Neuroprotective effects of 17beta-estradiol associate with KATP in rat brain. |
Zhang D, etal., Neuroreport. 2012 Nov 14;23(16):952-7. doi: 10.1097/WNR.0b013e3283598de6.
|
68. |
The E23K variation in the KCNJ11 gene is associated with type 2 diabetes in Chinese and East Asian population. |
Zhou D, etal., J Hum Genet. 2009 Jun 5.
|
69. |
Different localization of ATP sensitive K+ channel subunits in rat testis. |
Zhou M, etal., Anat Rec (Hoboken). 2011 Apr;294(4):729-37. doi: 10.1002/ar.21348. Epub 2011 Feb 15.
|
70. |
Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cells. |
Zhou M, etal., Brain Res Mol Brain Res 2002 May 30;101(1-2):23-32.
|
71. |
ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes. |
Zhou M, etal., J Histochem Cytochem. 2005 Dec;53(12):1491-500. Epub 2005 Jun 27.
|
72. |
Engineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutations. |
Zhou Q, etal., Channels (Austin). 2013 Jul-Aug;7(4):313-7. Epub 2013 May 21.
|
73. |
KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy. |
Zoga V, etal., Mol Pain. 2010 Jan 26;6:6. doi: 10.1186/1744-8069-6-6.
|