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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iprodione
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Accession:CHEBI:28909 term browser browse the term
Definition:An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide.
Synonyms:exact_synonym: 3-(3,5-dichlorophenyl)-2,4-dioxo-N-(propan-2-yl)-imidazolidine-1-carboxamide
 related_synonym: 3-(3,5-dichlorophenyl)-1-(1-methylethyl)carbamoylhydantoin;   3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide;   3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxoimidazolidine-1-carboxamide;   3-(3,5-dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide;   3-(3,5-dichlorophenyl)hydantoin-1-carboxylic acid isopropylamide;   Formula=C13H13Cl2N3O3;   InChI=1S/C13H13Cl2N3O3/c1-7(2)16-12(20)17-6-11(19)18(13(17)21)10-4-8(14)3-9(15)5-10/h3-5,7H,6H2,1-2H3,(H,16,20);   InChIKey=ONUFESLQCSAYKA-UHFFFAOYSA-N;   Rovral;   Rovrol;   SMILES=CC(C)NC(=O)N1CC(=O)N(C1=O)c1cc(Cl)cc(Cl)c1
 alt_id: CHEBI:24871;   CHEBI:8902
 xref: Beilstein:895003;   CAS:36734-19-7;   HMDB:HMDB0031795;   KEGG:C11208
 xref_mesh: MESH:C033148
 xref: PMID:11451425;   PMID:22115616;   PMID:22262495;   PPDB:403;   Patent:CN103053579;   Patent:CN103392726;   Patent:DE2149923;   Patent:US3755350;   Pesticides:iprodione;   Reaxys:895003;   UM-BBD_compID:c0635;   Wikipedia:Iprodione


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iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO
EXP		 iprodione binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of ALDH2 mRNA; [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of and results in decreased activity of ALDH2 protein CTD PMID:34830855 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Anxa10 annexin A10 increases expression ISO iprodione results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648 		JBrowse link
G Ar androgen receptor multiple interactions
affects binding		 ISO [iprodione binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; iprodione inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; iprodione inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
iprodione binds to AR protein		 CTD PMID:19564212 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP iprodione results in decreased expression of BCL2 protein
Chlorpyrifos promotes the reaction [iprodione results in decreased expression of BCL2 protein]; iprodione promotes the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]		 CTD PMID:33586219 PMID:34060014 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 EXP iprodione results in increased expression of CASP3 protein
Chlorpyrifos promotes the reaction [iprodione results in increased expression of CASP3 protein]; iprodione promotes the reaction [Chlorpyrifos results in increased expression of CASP3 protein]		 CTD PMID:33586219 PMID:34060014 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in decreased expression of CDH1 protein; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in decreased expression of CDH1 protein CTD PMID:34503147 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cldn11 claudin 11 increases expression
multiple interactions		 EXP iprodione results in increased expression of CLDN11 protein
[carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein		 CTD PMID:28576679 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO iprodione results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO iprodione results in increased expression of CYP1A1 mRNA; iprodione results in increased expression of CYP1A1 protein CTD PMID:16696176 PMID:32194361 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases expression ISO iprodione results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO iprodione results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO iprodione results in increased expression of DDIT3 mRNA CTD PMID:16696176 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO iprodione binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO iprodione binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO iprodione results in increased expression of FOS mRNA CTD PMID:16696176 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression		 EXP Chlorpyrifos inhibits the reaction [iprodione results in decreased expression of FSHB protein]; iprodione inhibits the reaction [Chlorpyrifos results in decreased expression of FSHB protein]; iprodione promotes the reaction [Chlorpyrifos results in decreased expression of FSHB protein] CTD PMID:33586219 PMID:34060014 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO iprodione results in increased expression of GADD45A mRNA CTD PMID:16696176 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein CTD PMID:28576679 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO iprodione results in increased expression of GSTA2 mRNA CTD PMID:16696176 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein; [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in increased expression of H2AX protein; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of H2AX protein CTD PMID:22389207 PMID:34503147 PMID:34830855 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression		 EXP [Chlorpyrifos co-treated with iprodione] results in decreased expression of HSD17B3 mRNA; [iprodione co-treated with Chlorpyrifos] results in decreased expression of HSD17B3 mRNA
iprodione results in decreased expression of HSD17B3 mRNA		 CTD PMID:33586219 PMID:34060014 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO iprodione results in increased expression of HSPA5 mRNA CTD PMID:16696176 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
decreases expression		 EXP Chlorpyrifos inhibits the reaction [iprodione results in decreased expression of LHB protein]; iprodione inhibits the reaction [Chlorpyrifos results in decreased expression of LHB protein] CTD PMID:34060014 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein; iprodione binds to and results in increased activity of NR1I2 protein CTD PMID:25028461 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions		 EXP iprodione results in decreased expression of NR5A1 mRNA
[iprodione co-treated with Chlorpyrifos] results in decreased expression of NR5A1 mRNA; iprodione promotes the reaction [Chlorpyrifos results in decreased expression of NR5A1 mRNA]		 CTD PMID:33586219 PMID:34060014 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions		 ISO iprodione results in increased activity of PPARG protein
iprodione binds to and results in increased activity of PPARG protein		 CTD PMID:20143881 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions		 EXP iprodione results in decreased expression of PPARGC1A mRNA
Chlorpyrifos promotes the reaction [iprodione results in decreased expression of PPARGC1A mRNA]; iprodione promotes the reaction [Chlorpyrifos results in decreased expression of PPARGC1A mRNA]		 CTD PMID:33586219 PMID:34060014 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 EXP [iprodione co-treated with Chlorpyrifos] results in decreased expression of SIRT1 mRNA; iprodione promotes the reaction [Chlorpyrifos results in decreased expression of SIRT1 mRNA]
iprodione results in decreased expression of SIRT1 mRNA		 CTD PMID:33586219 PMID:34060014 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Stmn1 stathmin 1 increases expression EXP iprodione results in increased expression of STMN1 mRNA CTD PMID:28576679 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases expression		 EXP [Chlorpyrifos co-treated with iprodione] results in decreased expression of TERT mRNA; [iprodione co-treated with Chlorpyrifos] results in decreased expression of TERT mRNA
iprodione results in decreased expression of TERT mRNA		 CTD PMID:33586219 PMID:34060014 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO iprodione binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO iprodione binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Acetylcysteine inhibits the reaction [iprodione inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; iprodione inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:33226166 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] affects the expression of TP53BP1 protein; [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] affects the expression of TP53BP1 protein CTD PMID:34503147 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      application 19658
        pesticide 17924
          nematicide 6490
            iprodione 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      carboacyl group 17696
                                        univalent carboacyl group 17696
                                          carbamoyl group 17546
                                            carboxamide 17546
                                              monocarboxylic acid amide 15681
                                                urea 5579
                                                  ureas 5577
                                                    iprodione 36
paths to the root