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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:arsenic acid
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Accession:CHEBI:18231 term browser browse the term
Definition:An arsenic oxoacid comprising one oxo group and three hydroxy groups attached to a central arsenic atom.
Synonyms:exact_synonym: tetraoxoarsenic acid;   trihydrogen tetraoxoarsenate;   trihydroxidooxidoarsenic
 related_synonym: Formula=AsH3O4;   Formula=H3AsO4;   H3AsO4;   InChI=1S/AsH3O4/c2-1(3,4)5/h(H3,2,3,4,5);   InChIKey=DJHGAFSJWGLOIV-UHFFFAOYSA-N;   Orthoarsenic acid;   SMILES=O[As](O)(O)=O;   [AsO(OH)3];   arsoric acid
 alt_id: CHEBI:22631;   CHEBI:2843
 xref: CAS:7778-39-4;   Gmelin:2294;   KEGG:C01478
 xref_mesh: MESH:C025657
 xref: PPDB:2913
 cyclic_relationship: is_conjugate_acid_of CHEBI:22629;   is_conjugate_acid_of CHEBI:48600


show annotations for term's descendants           Sort by:
arsenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) decreases response to substance EXP ABCC1 protein results in decreased susceptibility to arsenic acid; ABCC1 results in decreased susceptibility to arsenic acid CTD PMID:7954421 PMID:21918036 PMID:29752257 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP AIFM1 protein inhibits the reaction [arsenic acid results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [arsenic acid results in decreased reduction of Adenine Nucleotides] CTD PMID:15316071 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation ISO arsenic acid results in decreased phosphorylation of AKT1 protein CTD PMID:26763397 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALAD aminolevulinate dehydratase decreases activity ISO arsenic acid results in decreased activity of ALAD protein CTD PMID:15202869 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G AS3MT arsenite methyltransferase affects abundance
multiple interactions
affects methylation
affects metabolic processing
affects secretion		 ISO AS3MT protein affects the abundance of arsenic acid
Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]
AS3MT protein affects the methylation of arsenic acid
AS3MT protein affects the secretion of arsenic acid		 CTD PMID:15606138 PMID:19691357 NCBI chr10:102,869,470...102,901,899
Ensembl chr10:102,869,470...102,901,899 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression ISO arsenic acid results in increased expression of BCL2 mRNA CTD PMID:8946558 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) increases activity ISO arsenic acid results in increased activity of CASP12 protein CTD PMID:18226606 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CAT catalase multiple interactions ISO [CAT protein results in decreased oxidation of arsenite] which results in decreased chemical synthesis of arsenic acid CTD PMID:18619986 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions
increases expression		 ISO Dietary Fats promotes the reaction [arsenic acid results in increased expression of COL3A1 mRNA] CTD PMID:18296743 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 increases expression ISO arsenic acid results in increased expression of CXCL1 mRNA CTD PMID:18296743 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion EXP arsenic acid results in increased secretion of CXCL8 protein CTD PMID:29355690 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G DPP4 dipeptidyl peptidase 4 decreases expression EXP arsenic acid results in decreased expression of DPP4 mRNA CTD PMID:29355690 NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394 		JBrowse link
G EGFR epidermal growth factor receptor increases phosphorylation
multiple interactions		 EXP arsenic acid results in increased phosphorylation of EGFR protein
EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK1 protein]; EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK3 protein]		 CTD PMID:14674888 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G ELK1 ETS transcription factor ELK1 increases activity ISO arsenic acid results in increased activity of ELK1 protein CTD PMID:10445758 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604 		JBrowse link
G FOLR2 folate receptor beta decreases response to substance ISO FOLR2 results in decreased susceptibility to arsenic acid CTD PMID:14745917 NCBI chr11:72,216,794...72,221,950
Ensembl chr11:72,216,601...72,221,950 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO arsenic acid results in increased expression of FOS CTD PMID:10445758 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOXO1 forkhead box O1 affects localization ISO arsenic acid affects the localization of FOXO1 protein CTD PMID:26763397 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641 		JBrowse link
G FOXO3 forkhead box O3 affects localization ISO arsenic acid affects the localization of FOXO3 protein CTD PMID:26763397 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774 		JBrowse link
G GLB1 galactosidase beta 1 increases activity ISO arsenic acid results in increased activity of GLB1 protein CTD PMID:26763397 NCBI chr 3:32,961,108...33,097,146
Ensembl chr 3:32,996,609...33,097,202 		JBrowse link
G GPX1 glutathione peroxidase 1 increases expression ISO arsenic acid results in increased expression of GPX1 mRNA; arsenic acid results in increased expression of GPX1 protein CTD PMID:19429247 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GPX2 glutathione peroxidase 2 decreases expression ISO arsenic acid results in decreased expression of GPX2 mRNA CTD PMID:19429247 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746 		JBrowse link
G GPX4 glutathione peroxidase 4 increases expression ISO arsenic acid results in increased expression of GPX4 mRNA; arsenic acid results in increased expression of GPX4 protein CTD PMID:19429247 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G GRB2 growth factor receptor bound protein 2 multiple interactions EXP arsenic acid promotes the reaction [SHC1 protein binds to GRB2 protein] CTD PMID:14674888 NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression ISO arsenic acid analog results in decreased expression of GRIA1 mRNA CTD PMID:19761793 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression ISO arsenic acid analog results in decreased expression of GRIA2 mRNA CTD PMID:19761793 NCBI chr 4:157,220,120...157,366,075
Ensembl chr 4:157,204,182...157,387,146 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 increases reduction EXP GSTO1 protein results in increased reduction of arsenic acid CTD PMID:16930657 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO arsenic acid results in increased expression of HMOX1 protein CTD PMID:18226606 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 affects methylation ISO arsenic acid affects the methylation of HSD11B1 gene CTD PMID:26855884 NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO arsenic acid results in increased expression of HSD11B2 mRNA CTD PMID:26855884 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression		 ISO Dietary Fats promotes the reaction [arsenic acid results in increased expression of IL6 mRNA] CTD PMID:18296743 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 increases activity EXP arsenic acid results in increased activity of MAP2K1 protein CTD PMID:14674888 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 increases activity EXP arsenic acid results in increased activity of MAP2K2 protein CTD PMID:14674888 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases activity
multiple interactions		 EXP arsenic acid results in increased activity of MAPK1 protein
EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]		 CTD PMID:14674888 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases activity		 EXP EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein] CTD PMID:14674888 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression ISO
EXP		 arsenic acid results in increased expression of MYC
arsenic acid results in increased expression of MYC mRNA		 CTD PMID:10445758 PMID:29355690 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO arsenic acid affects the localization of NFE2L2 protein
Sodium Selenite promotes the reaction [arsenic acid affects the localization of NFE2L2 protein]		 CTD PMID:19429247 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 decreases methylation
increases expression		 ISO arsenic acid results in decreased methylation of NR3C1 gene
arsenic acid results in increased expression of NR3C1 mRNA		 CTD PMID:26855884 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G OTC ornithine transcarbamylase increases reduction ISO OTC protein results in increased reduction of arsenic acid CTD PMID:19248796 NCBI chr  X:38,327,684...38,422,928
Ensembl chr  X:38,327,598...38,422,908 		JBrowse link
G PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 multiple interactions EXP PAPSS1 protein binds to and affects the metabolism of arsenic acid CTD PMID:15065880 NCBI chr 4:107,613,666...107,720,234
Ensembl chr 4:107,590,276...107,720,234 		JBrowse link
G PNP purine nucleoside phosphorylase increases reduction
increases metabolic processing
multiple interactions		 EXP PNP protein results in increased reduction of arsenic acid
PNP protein results in increased metabolism of arsenic acid
[PNP protein results in increased metabolism of arsenic acid] which results in increased chemical synthesis of arsenite		 CTD PMID:12928150 PMID:15929903 NCBI chr14:20,469,406...20,477,089
Ensembl chr14:20,461,992...20,477,094 		JBrowse link
G SELENOF selenoprotein F decreases expression ISO arsenic acid results in decreased expression of SELENOF mRNA CTD PMID:19429247 NCBI chr 1:86,862,445...86,914,577
Ensembl chr 1:86,862,445...86,914,424 		JBrowse link
G SELENOH selenoprotein H decreases expression ISO arsenic acid results in decreased expression of SELENOH mRNA CTD PMID:19429247 NCBI chr11:57,741,491...57,743,550
Ensembl chr11:57,741,491...57,743,554 		JBrowse link
G SELENOI selenoprotein I decreases expression ISO arsenic acid results in decreased expression of SELENOI mRNA CTD PMID:19429247 NCBI chr 2:26,346,143...26,395,885
Ensembl chr 2:26,308,547...26,395,885 		JBrowse link
G SELENOK selenoprotein K decreases expression ISO arsenic acid results in decreased expression of SELENOK mRNA CTD PMID:19429247 NCBI chr 3:53,884,417...53,891,859
Ensembl chr 3:53,884,417...53,891,885 		JBrowse link
G SELENOM selenoprotein M decreases expression ISO arsenic acid results in decreased expression of SELENOM mRNA CTD PMID:19429247 NCBI chr22:31,104,777...31,107,568
Ensembl chr22:31,104,772...31,120,069 		JBrowse link
G SELENOS selenoprotein S decreases expression ISO arsenic acid results in decreased expression of SELENOS mRNA CTD PMID:19429247 NCBI chr15:101,270,809...101,277,485
Ensembl chr15:101,270,817...101,277,500 		JBrowse link
G SHC1 SHC adaptor protein 1 increases phosphorylation
multiple interactions		 EXP arsenic acid results in increased phosphorylation of SHC1 protein
arsenic acid promotes the reaction [SHC1 protein binds to GRB2 protein]		 CTD PMID:14674888 NCBI chr 1:154,962,298...154,974,376
Ensembl chr 1:154,962,298...154,974,395 		JBrowse link
G SI sucrase-isomaltase decreases expression EXP arsenic acid results in decreased expression of SI mRNA CTD PMID:29355690 NCBI chr 3:164,978,898...165,157,921
Ensembl chr 3:164,978,898...165,078,496 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 increases import EXP SLCO1B1 protein results in increased import of arsenic acid CTD PMID:16479312 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796 		JBrowse link
G SNCA synuclein alpha decreases expression ISO arsenic acid results in decreased expression of SNCA CTD PMID:25639566 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
G STK4 serine/threonine kinase 4 increases phosphorylation ISO arsenic acid results in increased phosphorylation of STK4 protein CTD PMID:26763397 NCBI chr20:44,966,512...45,080,021
Ensembl chr20:44,966,494...45,080,021 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression		 ISO Dietary Fats promotes the reaction [arsenic acid results in increased expression of TIMP1 mRNA] CTD PMID:18296743 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression ISO arsenic acid results in increased expression of TIMP2 mRNA CTD PMID:18296743 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G TNF tumor necrosis factor increases secretion
increases expression		 ISO arsenic acid results in increased secretion of TNF protein
arsenic acid results in increased expression of TNF mRNA		 CTD PMID:9548797 PMID:18296743 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 increases expression ISO arsenic acid results in increased expression of TRP53 mRNA CTD PMID:8946558 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TXNRD1 thioredoxin reductase 1 increases activity
multiple interactions
increases expression		 ISO arsenic acid results in increased activity of TXNRD1 protein
Sodium Selenite promotes the reaction [arsenic acid results in increased activity of TXNRD1 protein]
arsenic acid results in increased expression of TXNRD1 mRNA; arsenic acid results in increased expression of TXNRD1 protein		 CTD PMID:19429247 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307 		JBrowse link
G VIL1 villin 1 decreases expression EXP arsenic acid results in decreased expression of VIL1 mRNA CTD PMID:29355690 NCBI chr 2:218,419,123...218,453,295
Ensembl chr 2:218,419,121...218,453,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26050
    chemical entity 26029
      atom 26025
        metalloid atom 16427
          arsenic atom 15113
            arsenic molecular entity 15113
              arsenic oxoacid 4452
                arsenic acid 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 26050
    subatomic particle 26025
      composite particle 26025
        hadron 26025
          baryon 26025
            nucleon 26025
              atomic nucleus 26025
                atom 26025
                  main group element atom 25850
                    p-block element atom 25850
                      chalcogen 24932
                        oxygen atom 24821
                          oxygen molecular entity 24821
                            hydroxides 24065
                              oxoacid 23000
                                pnictogen oxoacid 13804
                                  arsenic oxoacid 4452
                                    arsenic acid 57
paths to the root