(+)-schisandrin B multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SHC1 mRNA] CTD PMID:31150632 (R)-noradrenaline multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 1 more ... CTD PMID:19168439 (R)-noradrenaline increases phosphorylation ISO Shc1 (Rattus norvegicus) 6480464 Norepinephrine results in increased phosphorylation of SHC1 protein alternative form CTD PMID:19168439 17beta-estradiol multiple interactions EXP 6480464 Estradiol binds to and results in increased phosphorylation of SHC1 protein more ... CTD PMID:16024245 and PMID:23094148 17beta-estradiol increases phosphorylation EXP 6480464 Estradiol results in increased phosphorylation of SHC1 protein CTD PMID:23094148 17beta-estradiol multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 mRNA and [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 protein CTD PMID:22465879 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO Shc1 (Mus musculus) 6480464 2 more ... CTD PMID:30294300 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 CBL protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [SHC1 protein binds to [GRB2 protein binds to SOS1 protein]]] and Tetrachlorodibenzodioxin promotes the reaction [SHC1 protein binds to [GRB2 protein binds to SOS1 protein]] CTD PMID:9918770 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Shc1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of SHC1 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Shc1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the expression of SHC1 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Shc1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SHC1 mRNA CTD PMID:21570461 and PMID:24680724 2,3-dimethoxynaphthalene-1,4-dione increases expression EXP 6480464 2 more ... CTD PMID:19031421 2,4-dinitrotoluene affects expression ISO Shc1 (Rattus norvegicus) 6480464 2 and 4-dinitrotoluene affects the expression of SHC1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO Shc1 (Rattus norvegicus) 6480464 2 and 6-dinitrotoluene affects the expression of SHC1 mRNA CTD PMID:21346803 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] and bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 3-chloropropane-1,2-diol increases expression ISO Shc1 (Rattus norvegicus) 6480464 alpha-Chlorohydrin results in increased expression of SHC1 protein CTD PMID:34915118 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SHC1 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SHC1 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol increases expression EXP 6480464 bisphenol S results in increased expression of SHC1 protein CTD PMID:31945527 4,4'-sulfonyldiphenol decreases methylation ISO Shc1 (Mus musculus) 6480464 bisphenol S results in decreased methylation of SHC1 exon CTD PMID:33297965 4,4'-sulfonyldiphenol increases expression ISO Shc1 (Mus musculus) 6480464 bisphenol S results in increased expression of SHC1 mRNA CTD PMID:30951980 4-vinylcyclohexene dioxide affects expression ISO Shc1 (Mus musculus) 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of SHC1 mRNA CTD PMID:20829426 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of SHC1 mRNA CTD PMID:19151715 6-propyl-2-thiouracil decreases expression ISO Shc1 (Rattus norvegicus) 6480464 Propylthiouracil results in decreased expression of SHC1 mRNA CTD PMID:24780913 6-propyl-2-thiouracil increases expression ISO Shc1 (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of SHC1 mRNA CTD PMID:30047161 acrylamide increases expression ISO Shc1 (Mus musculus) 6480464 Acrylamide results in increased expression of SHC1 mRNA CTD PMID:36599426 and PMID:36997053 aflatoxin B1 affects expression EXP 6480464 Aflatoxin B1 affects the expression of SHC1 protein CTD PMID:20106945 aflatoxin B1 decreases methylation EXP 6480464 Aflatoxin B1 results in decreased methylation of SHC1 exon and Aflatoxin B1 results in decreased methylation of SHC1 gene CTD PMID:27153756 and PMID:30157460 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of SHC1 mRNA CTD PMID:22100608 and PMID:27153756 Aflatoxin B2 alpha decreases methylation EXP 6480464 aflatoxin B2 results in decreased methylation of SHC1 exon CTD PMID:30157460 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of SHC1 more ... CTD PMID:21778425 and PMID:23993977 aldehydo-D-glucose multiple interactions EXP 6480464 SIRT1 inhibits the reaction [Glucose results in increased expression of SHC1] more ... CTD PMID:21778425 and PMID:23993977 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of SHC1 mRNA CTD PMID:33167477 aluminium oxide multiple interactions EXP 6480464 [Aluminum Oxide co-treated with Magnesium] results in increased expression of SHC1 protein and [Aluminum Oxide co-treated with Magnesium] results in increased expression of SHC1 protein alternative form CTD PMID:12209937 amitrole increases expression ISO Shc1 (Rattus norvegicus) 6480464 Amitrole results in increased expression of SHC1 mRNA CTD PMID:30047161 ammonium chloride affects expression ISO Shc1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of SHC1 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [diallyl trisulfide results in increased phosphorylation of SHC1 protein] CTD PMID:21616139 and PMID:22020565 apocynin multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 mRNA] and acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 protein] CTD PMID:23270704 aristolochic acid A increases expression EXP 6480464 aristolochic acid I results in increased expression of SHC1 mRNA CTD PMID:33212167 arsane multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of Arsenic] which affects the splicing of SHC1 mRNA CTD PMID:35072517 arsenic acid increases phosphorylation EXP 6480464 arsenic acid results in increased phosphorylation of SHC1 protein CTD PMID:14674888 arsenic acid multiple interactions EXP 6480464 arsenic acid promotes the reaction [SHC1 protein binds to GRB2 protein] CTD PMID:14674888 arsenic atom multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of Arsenic] which affects the splicing of SHC1 mRNA CTD PMID:35072517 arsenite(3-) multiple interactions EXP 6480464 arsenite promotes the reaction [SHC1 protein binds to GRB2 protein] CTD PMID:14674888 arsenite(3-) increases response to substance ISO Shc1 (Mus musculus) 6480464 SHC1 protein results in increased susceptibility to arsenite CTD PMID:24184494 arsenite(3-) increases expression ISO Shc1 (Mus musculus) 6480464 arsenite results in increased expression of SHC1 CTD PMID:24184494 arsenite(3-) increases phosphorylation EXP 6480464 arsenite results in increased phosphorylation of SHC1 protein CTD PMID:14674888 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of SHC1 mRNA CTD PMID:22521957 arsenous acid multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of SHC1 mRNA CTD PMID:25913414 azoxystrobin decreases expression EXP 6480464 azoxystrobin results in decreased expression of SHC1 mRNA CTD PMID:33512557 benzene decreases expression EXP 6480464 Benzene results in decreased expression of SHC1 mRNA CTD PMID:33064461 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of SHC1 mRNA CTD PMID:21632981 and PMID:32234424 benzo[e]pyrene decreases methylation EXP 6480464 benzo(e)pyrene results in decreased methylation of SHC1 exon CTD PMID:30157460 bisphenol A affects expression ISO Shc1 (Rattus norvegicus) 6480464 bisphenol A affects the expression of SHC1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO Shc1 (Mus musculus) 6480464 bisphenol A results in increased expression of SHC1 mRNA CTD PMID:33221593 bisphenol A decreases expression ISO Shc1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of SHC1 mRNA CTD PMID:34947998 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of SHC1 mRNA CTD PMID:30903817 bisphenol F increases expression ISO Shc1 (Mus musculus) 6480464 bisphenol F results in increased expression of SHC1 mRNA CTD PMID:30951980 bortezomib multiple interactions EXP 6480464 [arsenic trioxide co-treated with Bortezomib] results in decreased expression of SHC1 mRNA CTD PMID:25913414 bortezomib decreases expression EXP 6480464 Bortezomib results in decreased expression of SHC1 mRNA CTD PMID:20471514 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of SHC1 protein CTD PMID:14499349 cadmium dichloride decreases expression ISO Shc1 (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased expression of SHC1 mRNA CTD PMID:33453195 caffeine decreases phosphorylation EXP 6480464 Caffeine results in decreased phosphorylation of SHC1 protein CTD PMID:35688186 calcium dichloride increases expression EXP 6480464 Calcium Chloride results in increased expression of SHC1 protein CTD PMID:25824407 calyculin a increases phosphorylation ISO Shc1 (Rattus norvegicus) 6480464 calyculin A results in increased phosphorylation of SHC1 protein alternative form CTD PMID:19168439 carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of SHC1 mRNA CTD PMID:25979313 carnosic acid multiple interactions EXP 6480464 salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein] and SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein] CTD PMID:24557422 carnosic acid increases expression EXP 6480464 salvin results in increased expression of SHC1 mRNA CTD PMID:24557422 carnosic acid decreases expression EXP 6480464 salvin results in decreased expression of SHC1 protein CTD PMID:24557422 chloropicrin decreases expression EXP 6480464 chloropicrin results in decreased expression of SHC1 mRNA CTD PMID:26352163 chlorpyrifos decreases expression ISO Shc1 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of SHC1 mRNA CTD PMID:37019170 cisplatin decreases response to substance EXP 6480464 SHC1 results in decreased susceptibility to Cisplatin CTD PMID:21849418 cisplatin increases expression ISO Shc1 (Mus musculus) 6480464 Cisplatin results in increased expression of SHC1 mRNA and Cisplatin results in increased expression of SHC1 protein CTD PMID:26768586 cisplatin multiple interactions ISO Shc1 (Mus musculus) 6480464 Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter] more ... CTD PMID:20547441 and PMID:26768586 cisplatin increases phosphorylation ISO Shc1 (Mus musculus) 6480464 Cisplatin results in increased phosphorylation of SHC1 protein CTD PMID:20547441 cisplatin increases response to substance EXP 6480464 SHC1 protein results in increased susceptibility to Cisplatin CTD PMID:20547441 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of SHC1 mRNA CTD PMID:19376846 copper atom multiple interactions ISO Shc1 (Mus musculus) 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of SHC1 mRNA CTD PMID:15467011 copper(0) multiple interactions ISO Shc1 (Mus musculus) 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of SHC1 mRNA CTD PMID:15467011 copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of SHC1 mRNA CTD PMID:19549813 coumarin decreases phosphorylation EXP 6480464 coumarin results in decreased phosphorylation of SHC1 protein CTD PMID:35688186 crocidolite asbestos affects expression EXP 6480464 Asbestos and Crocidolite affects the expression of SHC1 mRNA CTD PMID:17331233 crocidolite asbestos increases expression EXP 6480464 Asbestos and Crocidolite results in increased expression of SHC1 mRNA CTD PMID:29523930 Cuprizon increases expression ISO Shc1 (Rattus norvegicus) 6480464 Cuprizone results in increased expression of SHC1 mRNA CTD PMID:26577399 and PMID:27523638 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of SHC1 mRNA CTD PMID:20106945 and PMID:25562108 D-glucose increases expression EXP 6480464 Glucose results in increased expression of SHC1 more ... CTD PMID:21778425 and PMID:23993977 D-glucose multiple interactions EXP 6480464 SIRT1 inhibits the reaction [Glucose results in increased expression of SHC1] more ... CTD PMID:21778425 and PMID:23993977 dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SHC1 mRNA CTD PMID:28628672 diallyl trisulfide decreases response to substance EXP 6480464 SHC1 protein modified form results in decreased susceptibility to diallyl trisulfide CTD PMID:22020565 diallyl trisulfide increases phosphorylation EXP 6480464 diallyl trisulfide results in increased phosphorylation of SHC1 protein CTD PMID:21616139 and PMID:22020565 diallyl trisulfide affects response to substance EXP 6480464 SHC1 protein affects the susceptibility to diallyl trisulfide CTD PMID:21616139 diallyl trisulfide multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [diallyl trisulfide results in increased phosphorylation of SHC1 protein] more ... CTD PMID:21616139 and PMID:22020565 diarsenic trioxide multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of SHC1 mRNA CTD PMID:25913414 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of SHC1 mRNA CTD PMID:22521957 dioxygen increases expression ISO Shc1 (Rattus norvegicus) 6480464 Oxygen deficiency results in increased expression of SHC1 mRNA and Oxygen deficiency results in increased expression of SHC1 protein CTD PMID:23270704 dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein more ... CTD PMID:24557422 dioxygen multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 mRNA] more ... CTD PMID:23270704 disodium selenite increases expression EXP 6480464 Sodium Selenite results in increased expression of SHC1 mRNA CTD PMID:18175754 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin affects localization ISO Shc1 (Rattus norvegicus) 6480464 Doxorubicin affects the localization of SHC1 protein modified form CTD PMID:26318906 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of SHC1 mRNA CTD PMID:29803840 doxorubicin increases oxidation ISO Shc1 (Rattus norvegicus) 6480464 Doxorubicin results in increased oxidation of SHC1 protein CTD PMID:26678157 doxorubicin increases response to substance ISO Shc1 (Rattus norvegicus) 6480464 SHC1 protein results in increased susceptibility to Doxorubicin CTD PMID:26318906 doxorubicin multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 Doxorubicin promotes the reaction [SHC1 protein binds to FOXO3A protein] more ... CTD PMID:26318906 ethanol increases expression ISO Shc1 (Mus musculus) 6480464 Ethanol results in increased expression of SHC1 mRNA CTD PMID:30319688 fenamidone increases expression ISO Shc1 (Mus musculus) 6480464 fenamidone results in increased expression of SHC1 mRNA CTD PMID:27029645 flutamide increases expression ISO Shc1 (Rattus norvegicus) 6480464 Flutamide results in increased expression of SHC1 mRNA CTD PMID:24136188 folic acid multiple interactions EXP 6480464 Folic Acid inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein] and Folic Acid inhibits the reaction [sodium arsenite results in increased expression of SHC1 protein] CTD PMID:26537450 and PMID:33360347 genistein decreases expression EXP 6480464 Genistein results in decreased expression of SHC1 mRNA CTD PMID:22228119 ginkgolide B multiple interactions ISO Shc1 (Mus musculus) 6480464 ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]] more ... CTD PMID:26768586 glafenine increases expression ISO Shc1 (Rattus norvegicus) 6480464 Glafenine results in increased expression of SHC1 mRNA CTD PMID:24136188 glucose increases expression EXP 6480464 Glucose results in increased expression of SHC1 more ... CTD PMID:21778425 and PMID:23993977 glucose multiple interactions EXP 6480464 SIRT1 inhibits the reaction [Glucose results in increased expression of SHC1] more ... CTD PMID:21778425 and PMID:23993977 glycidol increases expression ISO Shc1 (Rattus norvegicus) 6480464 glycidol results in increased expression of SHC1 mRNA CTD PMID:24915197 Goe 6976 multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 hispidin multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 hispidin inhibits the reaction [Doxorubicin results in increased expression of and results in decreased phosphorylation of and affects the localization of SHC1 protein] CTD PMID:26318906 hydrogen cyanide decreases expression ISO Shc1 (Mus musculus) 6480464 Hydrogen Cyanide results in decreased expression of SHC1 mRNA CTD PMID:33914522 hydrogen peroxide multiple interactions ISO Shc1 (Mus musculus) 6480464 Hydrogen Peroxide affects the reaction [SHC1 protein affects the expression of GPX3 mRNA] more ... CTD PMID:16972253 and PMID:32659284 hydrogen peroxide increases expression ISO Shc1 (Mus musculus) 6480464 Hydrogen Peroxide results in increased expression of SHC1 protein CTD PMID:32659284 hydrogen peroxide multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of SHC1 protein] more ... CTD PMID:19902159 more ... hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of SHC1 mRNA CTD PMID:19902159 more ... hydrogen peroxide multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SHC1 protein alternative form] more ... CTD PMID:19168439 hydrogen peroxide increases phosphorylation ISO Shc1 (Rattus norvegicus) 6480464 Hydrogen Peroxide results in increased phosphorylation of SHC1 protein alternative form CTD PMID:19168439 hydrogen peroxide increases response to substance ISO Shc1 (Mus musculus) 6480464 SHC1 protein results in increased susceptibility to Hydrogen Peroxide CTD PMID:16972253 indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SHC1 mRNA CTD PMID:28628672 inulin multiple interactions ISO Shc1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SHC1 mRNA CTD PMID:36331819 ivermectin decreases expression EXP 6480464 Ivermectin results in decreased expression of SHC1 protein CTD PMID:32959892 letrozole increases expression ISO Shc1 (Mus musculus) 6480464 letrozole results in increased expression of SHC1 protein CTD PMID:15967659 magnesium atom multiple interactions EXP 6480464 [Aluminum Oxide co-treated with Magnesium] results in increased expression of SHC1 protein and [Aluminum Oxide co-treated with Magnesium] results in increased expression of SHC1 protein alternative form CTD PMID:12209937 malathion increases expression EXP 6480464 Malathion results in increased expression of SHC1 mRNA CTD PMID:32069766 malonaldehyde multiple interactions ISO Shc1 (Mus musculus) 6480464 SHC1 protein promotes the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde] CTD PMID:32659284 mercury atom decreases expression EXP 6480464 Mercury results in decreased expression of SHC1 mRNA CTD PMID:16823088 mercury(0) decreases expression EXP 6480464 Mercury results in decreased expression of SHC1 mRNA CTD PMID:16823088 methapyrilene decreases methylation EXP 6480464 Methapyrilene results in decreased methylation of SHC1 exon CTD PMID:30157460 methimazole increases expression ISO Shc1 (Rattus norvegicus) 6480464 Methimazole results in increased expression of SHC1 mRNA CTD PMID:30047161 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of SHC1 mRNA CTD PMID:23179753 more ... methylmercury chloride multiple interactions EXP 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHC1 mRNA CTD PMID:27188386 metyrapone multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of SHC1 mRNA CTD PMID:37088303 microcystin-LR increases expression EXP 6480464 cyanoginosin LR results in increased expression of SHC1 mRNA CTD PMID:27796937 N-acetyl-L-cysteine multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein] CTD PMID:33360347 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of SHC1 protein] and Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein] CTD PMID:33360347 N-acetyl-L-cysteine multiple interactions ISO Shc1 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [SHC1 protein results in decreased expression of CDH1 protein] and Acetylcysteine inhibits the reaction [SHC1 protein results in increased expression of VIM protein] CTD PMID:32659284 N-methyl-N-nitrosourea multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 mRNA and [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 protein CTD PMID:22465879 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of SHC1 mRNA CTD PMID:19031421 nefazodone increases expression ISO Shc1 (Rattus norvegicus) 6480464 nefazodone results in increased expression of SHC1 mRNA CTD PMID:24136188 nickel atom increases expression EXP 6480464 Nickel results in increased expression of SHC1 mRNA CTD PMID:24768652 and PMID:25583101 nicotinamide increases expression EXP 6480464 Niacinamide results in increased expression of SHC1 mRNA and Niacinamide results in increased expression of SHC1 protein CTD PMID:21778425 nicotinamide multiple interactions EXP 6480464 Niacinamide promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein] CTD PMID:24557422 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of SHC1 mRNA CTD PMID:19287073 ozone multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of SHC1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of SHC1 mRNA CTD PMID:37088303 p-chloromercuribenzoic acid increases expression EXP 6480464 p-Chloromercuribenzoic Acid results in increased expression of SHC1 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions EXP 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHC1 mRNA CTD PMID:27188386 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of SHC1 mRNA CTD PMID:21420995 and PMID:25704631 paracetamol decreases expression ISO Shc1 (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of SHC1 mRNA CTD PMID:33387578 paraquat increases response to substance ISO Shc1 (Mus musculus) 6480464 SHC1 protein results in increased susceptibility to Paraquat CTD PMID:16972253 perfluorooctane-1-sulfonic acid multiple interactions ISO Shc1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SHC1 mRNA CTD PMID:36331819 phenobarbital increases expression ISO Shc1 (Mus musculus) 6480464 Phenobarbital results in increased expression of SHC1 mRNA CTD PMID:19270015 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of SHC1 mRNA CTD PMID:19159669 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of SHC1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHC1 mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate increases expression EXP 6480464 Tetradecanoylphorbol Acetate results in increased expression of SHC1 mRNA CTD PMID:19031421 phorbol 13-acetate 12-myristate increases phosphorylation ISO Shc1 (Rattus norvegicus) 6480464 Tetradecanoylphorbol Acetate results in increased phosphorylation of SHC1 protein alternative form CTD PMID:19168439 phorbol 13-acetate 12-myristate multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SHC1 protein alternative form] more ... CTD PMID:19168439 prazosin multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 Prazosin inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 progesterone multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 mRNA and [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 protein CTD PMID:22465879 propiconazole increases expression ISO Shc1 (Rattus norvegicus) 6480464 propiconazole results in increased expression of SHC1 mRNA CTD PMID:30047161 prostaglandin F2alpha increases phosphorylation ISO Shc1 (Rattus norvegicus) 6480464 Dinoprost results in increased phosphorylation of SHC1 protein alternative form CTD PMID:19168439 reactive oxygen species affects phosphorylation ISO Shc1 (Rattus norvegicus) 6480464 Reactive Oxygen Species affects the phosphorylation of SHC1 protein CTD PMID:19168439 reactive oxygen species multiple interactions ISO Shc1 (Mus musculus) 6480464 SHC1 protein promotes the reaction [CDH1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:32659284 reactive oxygen species multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 EGFR protein affects the reaction [Reactive Oxygen Species affects the phosphorylation of SHC1 protein] and PRKCD protein affects the reaction [Reactive Oxygen Species affects the phosphorylation of SHC1 protein] CTD PMID:19168439 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein] CTD PMID:24557422 Salvianolic acid A multiple interactions ISO Shc1 (Mus musculus) 6480464 salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of SHC1 mRNA] and salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of SHC1 protein] CTD PMID:23993977 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenomethionine affects expression EXP 6480464 Selenomethionine affects the expression of SHC1 mRNA CTD PMID:17222674 sirtinol multiple interactions EXP 6480464 sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter] CTD PMID:21778425 sirtinol increases expression EXP 6480464 sirtinol results in increased expression of SHC1 mRNA and sirtinol results in increased expression of SHC1 protein CTD PMID:21778425 sodium arsenite multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 [sodium arsenite results in increased phosphorylation of SHC1 protein] promotes the reaction [SHC1 protein modified form binds to GRB2 protein] more ... CTD PMID:33360347 and PMID:9710602 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of SHC1 mRNA and sodium arsenite results in increased expression of SHC1 protein CTD PMID:26537450 and PMID:33360347 sodium arsenite multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of Arsenic] which affects the splicing of SHC1 mRNA more ... CTD PMID:26537450 more ... sodium arsenite increases expression ISO Shc1 (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of SHC1 mRNA CTD PMID:33360347 sodium arsenite increases phosphorylation ISO Shc1 (Rattus norvegicus) 6480464 sodium arsenite results in increased phosphorylation of SHC1 protein CTD PMID:9710602 Soman increases expression ISO Shc1 (Rattus norvegicus) 6480464 Soman results in increased expression of SHC1 mRNA CTD PMID:19281266 streptozocin increases expression ISO Shc1 (Mus musculus) 6480464 Streptozocin results in increased expression of SHC1 mRNA and Streptozocin results in increased expression of SHC1 protein CTD PMID:21778425 streptozocin multiple interactions ISO Shc1 (Mus musculus) 6480464 SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SHC1 mRNA] and SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SHC1 protein] CTD PMID:21778425 sulindac multiple interactions EXP 6480464 Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SHC1 mRNA] CTD PMID:15190207 suramin multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein] CTD PMID:9710602 suramin increases expression EXP 6480464 Suramin results in increased expression of SHC1 mRNA and Suramin results in increased expression of SHC1 protein CTD PMID:21778425 tetrachloroethene increases expression EXP 6480464 Tetrachloroethylene results in increased expression of SHC1 mRNA CTD PMID:19031421 tetrachloromethane multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SHC1 mRNA] CTD PMID:31150632 tetrachloromethane increases expression ISO Shc1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of SHC1 protein CTD PMID:32659284 tetrachloromethane multiple interactions ISO Shc1 (Mus musculus) 6480464 MICAL2 mRNA promotes the reaction [Carbon Tetrachloride results in increased expression of SHC1 protein] more ... CTD PMID:32659284 tetrachloromethane increases expression ISO Shc1 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased expression of SHC1 mRNA CTD PMID:31150632 Tiron multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 1 more ... CTD PMID:19168439 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of SHC1 and trichostatin A results in increased expression of SHC1 mRNA CTD PMID:21778425 and PMID:26272509 trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHC1 mRNA CTD PMID:27188386 trimethyltin increases expression ISO Shc1 (Mus musculus) 6480464 trimethyltin results in increased expression of SHC1 mRNA CTD PMID:20833246 Triptolide increases expression ISO Shc1 (Rattus norvegicus) 6480464 triptolide results in increased expression of SHC1 protein CTD PMID:32519852 triptonide decreases expression ISO Shc1 (Mus musculus) 6480464 triptonide results in decreased expression of SHC1 mRNA CTD PMID:33045310 tyrphostin AG 1478 multiple interactions ISO Shc1 (Rattus norvegicus) 6480464 RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SHC1 protein alternative form] more ... CTD PMID:19168439 and PMID:9710602 valdecoxib increases expression ISO Shc1 (Rattus norvegicus) 6480464 valdecoxib results in increased expression of SHC1 mRNA CTD PMID:24136188 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of SHC1 mRNA CTD PMID:25979313 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of SHC1 mRNA CTD PMID:37505509 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of SHC1 mRNA CTD PMID:28001369 vinclozolin affects expression ISO Shc1 (Rattus norvegicus) 6480464 vinclozolin affects the expression of SHC1 mRNA CTD PMID:19015723 vorinostat multiple interactions EXP 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHC1 mRNA CTD PMID:27188386 vorinostat increases expression EXP 6480464 vorinostat results in increased expression of SHC1 mRNA CTD PMID:26272509
