Gene: GRIA2 (glutamate receptor, ionotropic, AMPA 2)  Homo sapiens
Symbol: GRIA2
Name: glutamate receptor, ionotropic, AMPA 2
Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AMPA-selective glutamate receptor 2; GluA2; gluR-2; gluR-B; GluR-K2; GLUR2; GLURB; glutamate receptor 2; glutamate receptor, ionotropic, 2; HBGR2; OTTHUMP00000165322; OTTHUMP00000165323; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943
Orthologs: Mus musculus : Gria2 (glutamate receptor, ionotropic, AMPA2 (alpha 2))  MGI
Rattus norvegicus : Gria2 (glutamate receptor, ionotropic, AMPA 2)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_14157,934,116 - 158,079,086+NCBI
Human Genome Assembly HuRef4153,892,713 - 154,037,902+NCBI
Human Genome Assembly GRCh374158,141,736 - 158,287,227+NCBI
Human Genome Assembly Build 364158,361,186 - 158,506,677+NCBI
Human Cytogenetic Map4q32.1 NCBI
Human Genome Assembly4158,499,639 - 158,642,707 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
  
More on GRIA2
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 732446
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2013-03-05
Status: ACTIVE



Contact Us |  About Us |  Jobs at RGD