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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Ganoderic acid A
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Accession:CHEBI:168262 term browser browse the term
Synonyms:exact_synonym: (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid;   (6R)-6-[(5R,7R,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid
 related_synonym: Formula=C30H44O7;   InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1;   InChIKey=DYOKDAQBNHPJFD-JNTBEZBXSA-N;   SMILES=O[C@@H]1[C@@]2([C@@]([C@](C1)([C@@H](CC(=O)C[C@@H](C)C(O)=O)C)[H])(CC(=O)C3=C2[C@@H](O)C[C@@]4([C@@]3(CCC(=O)C4(C)C)C)[H])C)C
 xref: CAS:81907-62-2;   Chemspider:413668;   Chemspider:78443571
 xref_mesh: MESH:C515005


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Ganoderic acid A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression
multiple interactions		 ISO ganoderic acid A results in decreased expression of ACACA mRNA
[Dietary Fats co-treated with ganoderic acid A] affects the expression of ACACA mRNA		 CTD PMID:29852127 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acly ATP citrate lyase multiple interactions
decreases expression		 ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of ACLY mRNA
ganoderic acid A results in decreased expression of ACLY mRNA		 CTD PMID:29852127 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of ACOX1 mRNA CTD PMID:29852127 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of ACSS2 mRNA CTD PMID:29852127 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:34029542 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of ADIPOQ mRNA CTD PMID:29852127 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Apoe apolipoprotein E decreases expression ISO ganoderic acid A results in decreased expression of APOE mRNA CTD PMID:29852127 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein] CTD PMID:30506662 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ganoderic acid A inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein] CTD PMID:30506662 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein] CTD PMID:30506662 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of CASP9 protein] CTD PMID:30506662 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of CPT1A mRNA CTD PMID:29852127 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO ganoderic acid A results in decreased expression of DHCR7 mRNA CTD PMID:29852127 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions
decreases expression		 ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of FADS2 mRNA
ganoderic acid A results in decreased expression of FADS2 mRNA		 CTD PMID:29852127 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression		 ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of FASN mRNA
ganoderic acid A results in decreased expression of FASN mRNA		 CTD PMID:29852127 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression ISO ganoderic acid A results in decreased expression of FDFT1 mRNA CTD PMID:29852127 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression
multiple interactions		 ISO ganoderic acid A results in decreased expression of FDPS mRNA
[Dietary Fats co-treated with ganoderic acid A] affects the expression of FDPS mRNA		 CTD PMID:29852127 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fut2 fucosyltransferase 2 decreases expression ISO ganoderic acid A results in decreased expression of FUT2 mRNA CTD PMID:29852127 NCBI chr 1:96,119,549...96,139,567
Ensembl chr 1:96,119,371...96,140,360 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of G6PD mRNA CTD PMID:29852127 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gk glycerol kinase multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of GK mRNA CTD PMID:29852127 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]; ganoderic acid A inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:29852127 PMID:30506662 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression
multiple interactions		 ISO ganoderic acid A results in decreased expression of HMGCR mRNA
[Dietary Fats co-treated with ganoderic acid A] affects the expression of HMGCR mRNA		 CTD PMID:29852127 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions
decreases expression		 ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of HMGCS1 mRNA
ganoderic acid A results in decreased expression of HMGCS1 mRNA		 CTD PMID:29852127 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein] CTD PMID:30506662 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein] CTD PMID:30506662 PMID:34029542 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO ganoderic acid A results in decreased expression of INSIG1 mRNA CTD PMID:29852127 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of INSIG2 mRNA CTD PMID:29852127 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of IRS1 mRNA CTD PMID:29852127 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of IRS2 mRNA CTD PMID:29852127 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK2 protein] CTD PMID:34029542 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression
multiple interactions		 ISO ganoderic acid A results in decreased expression of LDLR mRNA
[Dietary Fats co-treated with ganoderic acid A] affects the expression of LDLR mRNA		 CTD PMID:29852127 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lep leptin multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of LEP mRNA CTD PMID:29852127 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lss lanosterol synthase decreases expression ISO ganoderic acid A results in decreased expression of LSS mRNA CTD PMID:29852127 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO ganoderic acid A results in decreased expression of MSMO1 mRNA CTD PMID:29852127 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Msn moesin multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MSN protein] CTD PMID:34029542 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628 		JBrowse link
G Mvk mevalonate kinase decreases expression ISO ganoderic acid A results in decreased expression of MVK mRNA CTD PMID:29852127 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased phosphorylation of NFKBIA protein] CTD PMID:30506662 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO ganoderic acid A results in decreased expression of PCSK9 mRNA CTD PMID:29852127 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of PPARG mRNA CTD PMID:29852127 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of RELA protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased phosphorylation of RELA protein] CTD PMID:30506662 PMID:34029542 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased expression of RHOA protein] CTD PMID:34029542 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Scap SREBF chaperone multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of SCAP mRNA CTD PMID:29852127 NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression		 ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of SCD1 mRNA
ganoderic acid A results in decreased expression of SCD mRNA		 CTD PMID:29852127 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein] CTD PMID:34029542 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions		 ISO ganoderic acid A results in decreased expression of SREBF1 mRNA; ganoderic acid A results in decreased expression of SREBF1 protein
[Dietary Fats co-treated with ganoderic acid A] affects the expression of SREBF1 mRNA; [Dietary Fats co-treated with ganoderic acid A] affects the expression of SREBF1 protein		 CTD PMID:29852127 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
decreases expression		 ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of SREBF2 mRNA; [Dietary Fats co-treated with ganoderic acid A] affects the expression of SREBF2 protein
ganoderic acid A results in decreased expression of SREBF2 mRNA; ganoderic acid A results in decreased expression of SREBF2 protein		 CTD PMID:29852127 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein] CTD PMID:34029542 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:34029542 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein] CTD PMID:30506662 PMID:34029542 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in decreased expression of TXN protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in decreased expression of TXN protein] CTD PMID:30506662 PMID:34029542 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO ganoderic acid A inhibits the reaction [Cyclophosphamide results in increased expression of TXNIP protein] CTD PMID:30506662 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of UCP1 mRNA CTD PMID:29852127 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO [Dietary Fats co-treated with ganoderic acid A] affects the expression of UCP2 mRNA CTD PMID:29852127 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      atom 19832
        nonmetal atom 19770
          carbon atom 19727
            organic molecular entity 19727
              isoprenoid 14075
                terpenoid 13774
                  triterpenoid 1202
                    Ganoderic acid A 53
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    main group molecular entity 19782
                      s-block molecular entity 19620
                        hydrogen molecular entity 19607
                          hydrides 19113
                            organic hydride 18689
                              organic fundamental parent 18689
                                hydrocarbon 18431
                                  terpene 14075
                                    triterpene 1206
                                      triterpenoid 1202
                                        Ganoderic acid A 53
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