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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:scutellarein
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Accession:CHEBI:9062 term browser browse the term
Definition:Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.
Synonyms:exact_synonym: 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
 related_synonym: 4',5,6,7-Tetrahydroxyflavanone;   5,6,7,4'-Tetrahydroxyflavone;   5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;   6-Hydroxyapigenin;   Formula=C15H10O6;   InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H;   InChIKey=JVXZRQGOGOXCEC-UHFFFAOYSA-N;   Isocarthamidin;   SMILES=Oc1ccc(cc1)-c1cc(=O)c2c(O)c(O)c(O)cc2o1
 xref: CAS:529-53-3;   KEGG:C10184;   KNApSAcK:C00003834
 xref_mesh: MESH:C458179
 xref: MetaCyc:CPD-12726;   PMID:10724177;   Reaxys:289959
 cyclic_relationship: is_conjugate_acid_of CHEBI:78328



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scutellarein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
affects metabolic processing
multiple interactions
ISO scutellarein results in decreased activity of CYP1A1 protein
CYP1A1 protein affects the metabolism of scutellarein
[CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078 PMID:21482471 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of scutellarein CTD PMID:19666078 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
affects metabolic processing
multiple interactions
ISO scutellarein results in decreased activity of CYP1B1 protein
CYP1B1 protein affects the metabolism of scutellarein
[CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078 PMID:21482471 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Ins2 insulin 2 multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO hispidulin decreases phoshphorylation of JAK2 protein in colon and colorectum RGD PMID:29575334 RGD:149735333 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] CTD PMID:22759588 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] CTD PMID:22759588 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO hispidulin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose] CTD PMID:36870413 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases activity
multiple interactions
EXP hispidulin results in decreased activity of SLCO1B1 protein
[hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate
CTD PMID:32259555 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
JBrowse link
G Syn1 synapsin I affects response to substance ISO SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
pectolinarigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase increases phosphorylation
multiple interactions
ISO pectolinarigenin results in increased phosphorylation of ATM protein
TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein]
CTD PMID:37393350 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein] CTD PMID:37393350 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO pectolinarigenin results in increased expression of H2AX protein
TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein]
CTD PMID:37393350 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation
ISO Chloroquine promotes the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein] CTD PMID:37393350 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO pectolinarigenin results in decreased expression of MKI67 protein CTD PMID:37393350 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO pectolinarigenin results in increased expression of SQSTM1 protein
Chloroquine promotes the reaction [pectolinarigenin results in increased expression of SQSTM1 protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]
CTD PMID:37393350 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO pectolinarigenin binds to and results in increased expression of TOP2A protein; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein] CTD PMID:37393350 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO pectolinarigenin results in increased expression of TP53 protein
TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein]
CTD PMID:37393350 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO pectolinarigenin results in increased expression of TP53BP1 protein CTD PMID:37393350 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
affects binding
ISO UGT1A1 protein results in increased glucuronidation of pectolinarigenin
pectolinarigenin binds to UGT1A1 protein
CTD PMID:37797876 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects binding
increases glucuronidation
ISO pectolinarigenin binds to UGT1A3 protein
UGT1A3 protein results in increased glucuronidation of pectolinarigenin
CTD PMID:37797876 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects binding
increases glucuronidation
ISO pectolinarigenin binds to UGT1A9 protein
UGT1A9 protein results in increased glucuronidation of pectolinarigenin
CTD PMID:37797876 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation ISO UGT2B17 protein results in increased glucuronidation of pectolinarigenin CTD PMID:37797876 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
scutellarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP scutellarin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP scutellarin inhibits the reaction [cobaltous chloride results in decreased expression of BCL2L1 mRNA] CTD PMID:18442013 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp1 caspase 1 multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA] CTD PMID:37081038 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
scutellarin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]
scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]
CTD PMID:18442013 PMID:36252740 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP scutellarin results in decreased expression of FGF2 protein CTD PMID:16297343 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gsdmd gasdermin D multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of GSDMD protein] CTD PMID:37081038 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; MG 262 inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]] CTD PMID:25192544 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Il18 interleukin 18 multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:37081038 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO scutellarin inhibits the reaction [Zearalenone results in increased expression of JUN protein] CTD PMID:36252740 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] CTD PMID:36252740 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein] CTD PMID:25192544 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein] CTD PMID:37081038 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP scutellarin results in decreased expression of NOS2 protein CTD PMID:16297343 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP scutellarin results in increased expression of NOS3 protein CTD PMID:16297343 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA protein] CTD PMID:25192544 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO scutellarin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pla2g2a phospholipase A2 group IIA affects activity ISO scutellarin affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 mRNA]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 protein] CTD PMID:36252740 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
EXP
ISO
scutellarin results in decreased expression of VEGFA protein
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein]
CTD PMID:16297343 PMID:25192544 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            scutellarein 45
              4',5,6,7-tetramethoxyflavone 0
              4',6-dihydroxy-5,7-dimethoxyflavone 0
              6-hydroxy-4',5,7-trimethoxyflavone 0
              hispidulin 10
              ladanein 0
              pectolinarigenin + 13
              plantaginin 0
              salvigenin 0
              scutellarein 7-methyl ether 0
              scutellarin 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  oxacycle 17866
                                    benzopyran 11952
                                      1-benzopyran 11704
                                        flavonoid 7190
                                          anthoxanthin 4540
                                            flavones 4540
                                              hydroxyflavone 4518
                                                trihydroxyflavone 429
                                                  apigenin 292
                                                    scutellarein 45
                                                      4',5,6,7-tetramethoxyflavone 0
                                                      4',6-dihydroxy-5,7-dimethoxyflavone 0
                                                      6-hydroxy-4',5,7-trimethoxyflavone 0
                                                      hispidulin 10
                                                      ladanein 0
                                                      pectolinarigenin + 13
                                                      plantaginin 0
                                                      salvigenin 0
                                                      scutellarein 7-methyl ether 0
                                                      scutellarin 20
paths to the root