ONTOLOGY REPORT - ANNOTATIONS
| Term: | apigenin |
|
| Accession: | CHEBI:18388
|
browse the term
|
| Definition: | A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. |
| Synonyms: | exact_synonym: | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
| | related_synonym: | 2-(p-hydroxyphenyl)-5,7-dihydroxychromone; 4',5,7-Trihydroxyflavone; 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; C.I. Natural Yellow 1; C15H10O5; InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H; InChIKey=KZNIFHPLKGYRTM-UHFFFAOYSA-N; Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1; chamomile; spigenin; versulin |
| | alt_id: | CHEBI:12084; CHEBI:22588; CHEBI:2768 |
| | xref_casrn: | 520-36-5 |
| | xref: | Beilstein:262620 "Beilstein Registry Number"; ChEMBL:101564 "ChEMBL COMPOUND"; ChemIDplus:520-36-5 "CAS Registry Number"; CiteXplore:23304222 "PubMed citation"; CiteXplore:23344191 "PubMed citation"; CiteXplore:23354402 "PubMed citation"; CiteXplore:23359392 "PubMed citation"; HMDB:HMDB02124 "HMDB"; KEGG COMPOUND:520-36-5 "CAS Registry Number"; KEGG COMPOUND:C01477 "KEGG COMPOUND"; LIPID MAPS:LMPK12110005 "LIPID MAPS instance" |
| | xref_mesh: | MESH:D047310 |
| | xref: | MetaCyc:CPD-431 "MetaCyc"; Reaxys:262620 "Reaxys Registry Number"; Wikipedia:Apigenin "Wikipedia" |
| | cyclic_relationship: | is_conjugate_acid_of CHEBI:58470 |
|
|
apigenin
|
| G |
A2m |
alpha-2-macroglobulin |
|
multiple interactions |
EXP |
4 |
158,103,711 |
158,153,423 |
RGD:6480464 |
CTD |
| G |
Abcc1 |
ATP-binding cassette, subfamily C (CFTR/MRP), member 1 |
|
decreases activity |
ISO |
10 |
452,239 |
575,705 |
RGD:6480464 |
CTD |
| G |
Afg3l2 |
AFG3 ATPase family member 3-like 2 (S. cerevisiae) |
|
increases expression |
ISO |
18 |
63,930,652 |
63,976,211 |
RGD:6480464 |
CTD |
| G |
Afp |
alpha-fetoprotein |
|
affects binding |
EXP |
14 |
19,092,563 |
19,110,728 |
RGD:6480464 |
CTD |
| G |
Ahr |
aryl hydrocarbon receptor |
|
multiple interactions |
ISO |
6 |
54,205,104 |
54,240,268 |
RGD:6480464 |
CTD |
| G |
Ahr |
aryl hydrocarbon receptor |
|
multiple interactions |
ISO |
6 |
54,205,104 |
54,240,268 |
RGD:6480464 |
CTD |
| G |
Ahr |
aryl hydrocarbon receptor |
|
multiple interactions |
ISO |
6 |
54,205,104 |
54,240,268 |
RGD:6480464 |
CTD |
| G |
Ahr |
aryl hydrocarbon receptor |
|
multiple interactions |
ISO |
6 |
54,205,104 |
54,240,268 |
RGD:6480464 |
CTD |
| G |
Aip |
aryl-hydrocarbon receptor-interacting protein |
|
multiple interactions |
ISO |
1 |
206,697,248 |
206,704,457 |
RGD:6480464 |
CTD |
| G |
Akt1 |
v-akt murine thymoma viral oncogene homolog 1 |
|
multiple interactions |
ISO |
6 |
137,640,482 |
137,657,552 |
RGD:6480464 |
CTD |
| G |
Akt1 |
v-akt murine thymoma viral oncogene homolog 1 |
|
decreases expression |
ISO |
6 |
137,640,482 |
137,657,552 |
RGD:6480464 |
CTD |
| G |
Arhgap29 |
Rho GTPase activating protein 29 |
|
increases expression |
ISO |
2 |
218,619,428 |
218,679,087 |
RGD:6480464 |
CTD |
| G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
|
multiple interactions |
ISO |
2 |
190,333,978 |
190,391,015 |
RGD:6480464 |
CTD |
| G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
|
multiple interactions |
ISO |
2 |
190,333,978 |
190,391,015 |
RGD:6480464 |
CTD |
| G |
Atf6 |
activating transcription factor 6 |
|
multiple interactions |
ISO |
13 |
86,543,773 |
86,718,970 |
RGD:6480464 |
CTD |
| G |
Bcl2 |
B-cell CLL/lymphoma 2 |
|
decreases expression |
ISO |
13 |
12,730,736 |
12,905,108 |
RGD:6480464 |
CTD |
| G |
Bcl2 |
B-cell CLL/lymphoma 2 |
|
decreases response to substance |
ISO |
13 |
12,730,736 |
12,905,108 |
RGD:6480464 |
CTD |
| G |
Birc3 |
baculoviral IAP repeat-containing 3 |
|
increases cleavage |
ISO |
8 |
4,682,202 |
4,696,856 |
RGD:6480464 |
CTD |
| G |
Bnip3l |
BCL2/adenovirus E1B interacting protein 3-like |
|
increases expression |
ISO |
15 |
46,516,626 |
46,539,756 |
RGD:6480464 |
CTD |
| G |
Casp12 |
caspase 12 |
|
multiple interactions |
ISO |
8 |
2,082,933 |
2,110,511 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
multiple interactions |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases activity |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases cleavage |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
multiple interactions |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases activity |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases cleavage |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp7 |
caspase 7 |
|
increases activity |
ISO |
1 |
262,689,300 |
262,721,591 |
RGD:6480464 |
CTD |
| G |
Casp7 |
caspase 7 |
|
increases cleavage |
ISO |
1 |
262,689,300 |
262,721,591 |
RGD:6480464 |
CTD |
| G |
Casp8 |
caspase 8 |
|
increases cleavage |
ISO |
9 |
57,389,353 |
57,437,803 |
RGD:6480464 |
CTD |
| G |
Casp9 |
caspase 9, apoptosis-related cysteine peptidase |
|
increases cleavage |
ISO |
5 |
160,704,234 |
160,721,796 |
RGD:6480464 |
CTD |
| G |
Casp9 |
caspase 9, apoptosis-related cysteine peptidase |
|
increases cleavage |
ISO |
5 |
160,704,234 |
160,721,796 |
RGD:6480464 |
CTD |
| G |
Cat |
catalase |
|
decreases expression |
ISO |
3 |
88,654,077 |
88,686,212 |
RGD:6480464 |
CTD |
| G |
Cat |
catalase |
|
decreases response to substance |
ISO |
3 |
88,654,077 |
88,686,212 |
RGD:6480464 |
CTD |
| G |
Cat |
catalase |
|
increases expression |
ISO |
3 |
88,654,077 |
88,686,212 |
RGD:6480464 |
CTD |
| G |
Cat |
catalase |
|
increases activity |
ISO |
3 |
88,654,077 |
88,686,212 |
RGD:6480464 |
CTD |
| G |
Ccnb1 |
cyclin B1 |
|
decreases expression |
ISO |
2 |
31,574,600 |
31,581,784 |
RGD:6480464 |
CTD |
| G |
Cd40 |
CD40 molecule, TNF receptor superfamily member 5 |
|
multiple interactions |
ISO |
3 |
156,092,602 |
156,107,427 |
RGD:6480464 |
CTD |
| G |
Cdk1 |
cyclin-dependent kinase 1 |
|
multiple interactions |
ISO |
20 |
20,018,044 |
20,044,030 |
RGD:6480464 |
CTD |
| G |
Cdkal1 |
CDK5 regulatory subunit associated protein 1-like 1 |
|
increases expression |
ISO |
17 |
41,208,037 |
41,259,863 |
RGD:6480464 |
CTD |
| G |
Cdkal1 |
CDK5 regulatory subunit associated protein 1-like 1 |
|
increases expression |
ISO |
17 |
41,208,037 |
41,259,863 |
RGD:6480464 |
CTD |
| G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
|
multiple interactions |
ISO |
20 |
7,376,325 |
7,386,778 |
RGD:6480464 |
CTD |
| G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
|
increases expression |
ISO |
20 |
7,376,325 |
7,386,778 |
RGD:6480464 |
CTD |
| G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
|
increases expression |
ISO |
20 |
7,376,325 |
7,386,778 |
RGD:6480464 |
CTD |
| G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
|
increases expression |
ISO |
20 |
7,376,325 |
7,386,778 |
RGD:6480464 |
CTD |
| G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
|
increases expression |
ISO |
20 |
7,376,325 |
7,386,778 |
RGD:6480464 |
CTD |
| G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
|
increases expression |
ISO |
20 |
7,376,325 |
7,386,778 |
RGD:6480464 |
CTD |
| G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
|
increases expression |
ISO |
5 |
131,012,524 |
131,017,679 |
RGD:6480464 |
CTD |
| G |
Cebpb |
CCAAT/enhancer binding protein (C/EBP), beta |
|
decreases expression |
ISO |
3 |
158,826,021 |
158,827,848 |
RGD:6480464 |
CTD |
| G |
Cftr |
cystic fibrosis transmembrane conductance regulator |
|
increases activity |
ISO |
4 |
43,874,852 |
44,041,870 |
RGD:6480464 |
CTD |
| G |
Cftr |
cystic fibrosis transmembrane conductance regulator |
|
increases activity |
ISO |
4 |
43,874,852 |
44,041,870 |
RGD:6480464 |
CTD |
| G |
Cftr |
cystic fibrosis transmembrane conductance regulator |
|
affects localization |
ISO |
4 |
43,874,852 |
44,041,870 |
RGD:6480464 |
CTD |
| G |
Clca1 |
chloride channel accessory 1 |
|
decreases expression |
ISO |
2 |
243,057,135 |
243,084,146 |
RGD:6480464 |
CTD |
| G |
Cxcl12 |
chemokine (C-X-C motif) ligand 12 |
|
multiple interactions |
ISO |
4 |
153,503,576 |
153,516,423 |
RGD:6480464 |
CTD |
| G |
Cxcl12 |
chemokine (C-X-C motif) ligand 12 |
|
increases expression |
ISO |
4 |
153,503,576 |
153,516,423 |
RGD:6480464 |
CTD |
| G |
Cycs |
cytochrome c, somatic |
|
affects localization |
ISO |
4 |
78,825,878 |
78,827,978 |
RGD:6480464 |
CTD |
| G |
Cyp11b1 |
cytochrome P450, family 11, subfamily b, polypeptide 1 |
|
decreases expression |
ISO |
7 |
112,977,395 |
112,984,080 |
RGD:6480464 |
CTD |
| G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
|
decreases expression |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
increases expression |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
increases expression |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
|
decreases activity |
ISO |
8 |
61,439,062 |
61,447,861 |
RGD:6480464 |
CTD |
| G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
|
decreases activity |
ISO |
8 |
61,439,062 |
61,447,861 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
multiple interactions |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
increases chemical synthesis |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
multiple interactions |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
decreases activity |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
decreases activity |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
multiple interactions |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
|
multiple interactions |
ISO |
1 |
243,281,320 |
243,320,945 |
RGD:6480464 |
CTD |
| G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
|
decreases activity |
ISO |
12 |
9,517,016 |
9,541,000 |
RGD:6480464 |
CTD |
| G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
|
multiple interactions |
ISO |
12 |
9,517,016 |
9,541,000 |
RGD:6480464 |
CTD |
| G |
Ddit3 |
DNA-damage inducible transcript 3 |
|
multiple interactions |
ISO |
7 |
67,247,749 |
67,252,571 |
RGD:6480464 |
CTD |
| G |
Duox1 |
dual oxidase 1 |
|
decreases expression |
ISO |
3 |
109,095,250 |
109,128,415 |
RGD:6480464 |
CTD |
| G |
Eif5b |
eukaryotic translation initiation factor 5B |
|
increases expression |
ISO |
9 |
36,937,415 |
36,993,650 |
RGD:6480464 |
CTD |
| G |
Erbb2 |
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
|
multiple interactions |
ISO |
10 |
87,219,157 |
87,242,919 |
RGD:6480464 |
CTD |
| G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
|
multiple interactions |
ISO |
10 |
95,794,488 |
95,855,895 |
RGD:6480464 |
CTD |
| G |
Erp29 |
endoplasmic reticulum protein 29 |
|
increases expression |
ISO |
12 |
36,225,110 |
36,231,363 |
RGD:6480464 |
CTD |
| G |
Esr1 |
estrogen receptor 1 |
|
multiple interactions |
ISO |
1 |
35,523,680 |
35,759,891 |
RGD:6480464 |
CTD |
| G |
Esr1 |
estrogen receptor 1 |
|
affects binding |
ISO |
1 |
35,523,680 |
35,759,891 |
RGD:6480464 |
CTD |
| G |
Esr1 |
estrogen receptor 1 |
|
decreases expression |
ISO |
1 |
35,523,680 |
35,759,891 |
RGD:6480464 |
CTD |
| G |
Esr1 |
estrogen receptor 1 |
|
multiple interactions |
ISO |
1 |
35,523,680 |
35,759,891 |
RGD:6480464 |
CTD |
| G |
Esr1 |
estrogen receptor 1 |
|
increases activity |
ISO |
1 |
35,523,680 |
35,759,891 |
RGD:6480464 |
CTD |
| G |
Esr1 |
estrogen receptor 1 |
|
increases phosphorylation |
EXP |
1 |
35,523,680 |
35,759,891 |
RGD:6480464 |
CTD |
| G |
Esr1 |
estrogen receptor 1 |
|
increases activity |
ISO |
1 |
35,523,680 |
35,759,891 |
RGD:6480464 |
CTD |
| G |
Esr1 |
estrogen receptor 1 |
|
multiple interactions |
ISO |
1 |
35,523,680 |
35,759,891 |
RGD:6480464 |
CTD |
| G |
Esr2 |
estrogen receptor 2 (ER beta) |
|
multiple interactions |
ISO |
6 |
98,691,167 |
98,775,299 |
RGD:6480464 |
CTD |
| G |
Esr2 |
estrogen receptor 2 (ER beta) |
|
increases activity |
ISO |
6 |
98,691,167 |
98,775,299 |
RGD:6480464 |
CTD |
| G |
Esr2 |
estrogen receptor 2 (ER beta) |
|
increases activity |
ISO |
6 |
98,691,167 |
98,775,299 |
RGD:6480464 |
CTD |
| G |
Esr2 |
estrogen receptor 2 (ER beta) |
|
increases activity |
ISO |
6 |
98,691,167 |
98,775,299 |
RGD:6480464 |
CTD |
| G |
Esr2 |
estrogen receptor 2 (ER beta) |
|
increases activity |
ISO |
6 |
98,691,167 |
98,775,299 |
RGD:6480464 |
CTD |
| G |
Esr2 |
estrogen receptor 2 (ER beta) |
|
affects binding |
ISO |
6 |
98,691,167 |
98,775,299 |
RGD:6480464 |
CTD |
| G |
Fam178a |
family with sequence similarity 178, member A |
|
decreases expression |
ISO |
1 |
249,986,434 |
250,048,899 |
RGD:6480464 |
CTD |
| G |
Fas |
Fas (TNF receptor superfamily, member 6) |
|
decreases expression |
ISO |
1 |
238,259,443 |
238,274,745 |
RGD:6480464 |
CTD |
| G |
Fbp1 |
fructose-1,6-bisphosphatase 1 |
|
decreases expression |
ISO |
17 |
7,795,717 |
7,818,041 |
RGD:6480464 |
CTD |
| G |
Fos |
FBJ osteosarcoma oncogene |
|
multiple interactions |
ISO |
6 |
109,559,135 |
109,562,001 |
RGD:6480464 |
CTD |
| G |
Fos |
FBJ osteosarcoma oncogene |
|
multiple interactions |
ISO |
6 |
109,559,135 |
109,562,001 |
RGD:6480464 |
CTD |
| G |
Frmd4a |
FERM domain containing 4A |
|
increases expression |
ISO |
17 |
84,783,244 |
85,068,101 |
RGD:6480464 |
CTD |
| G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
|
increases expression |
ISO |
8 |
82,724,429 |
82,762,848 |
RGD:6480464 |
CTD |
| G |
Gli1 |
GLI family zinc finger 1 |
|
decreases expression |
ISO |
7 |
67,288,291 |
67,297,461 |
RGD:6480464 |
CTD |
| G |
Gpx1 |
glutathione peroxidase 1 |
|
increases expression |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Gsta4 |
glutathione S-transferase alpha 4 |
|
decreases expression |
ISO |
8 |
83,165,139 |
83,183,055 |
RGD:6480464 |
CTD |
| G |
Hif1a |
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
|
decreases expression |
ISO |
6 |
96,419,024 |
96,463,891 |
RGD:6480464 |
CTD |
| G |
Hmox1 |
heme oxygenase (decycling) 1 |
|
multiple interactions |
ISO |
19 |
13,963,139 |
13,969,960 |
RGD:6480464 |
CTD |
| G |
Hmox1 |
heme oxygenase (decycling) 1 |
|
decreases expression |
ISO |
19 |
13,963,139 |
13,969,960 |
RGD:6480464 |
CTD |
| G |
Hsp90b1 |
heat shock protein 90, beta, member 1 |
|
multiple interactions |
ISO |
7 |
23,332,986 |
23,347,525 |
RGD:6480464 |
CTD |
| G |
Hspa1a |
heat shock protein 1A |
|
decreases expression |
ISO |
20 |
3,945,716 |
3,959,552 |
RGD:6480464 |
CTD |
| G |
Hspa1a |
heat shock protein 1A |
|
decreases expression |
ISO |
20 |
3,945,716 |
3,959,552 |
RGD:6480464 |
CTD |
| G |
Hspa1b |
heat shock protein 1B |
|
affects expression |
ISO |
20 |
3,955,274 |
3,957,748 |
RGD:6480464 |
CTD |
| G |
Hspa1l |
heat shock protein 1-like |
|
decreases expression |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Hspa2 |
heat shock protein 2 |
|
decreases expression |
ISO |
6 |
99,000,541 |
99,003,041 |
RGD:6480464 |
CTD |
| G |
Hspa5 |
heat shock protein 5 |
|
multiple interactions |
ISO |
3 |
13,783,825 |
13,788,022 |
RGD:6480464 |
CTD |
| G |
Hspa5 |
heat shock protein 5 |
|
decreases expression |
ISO |
3 |
13,783,825 |
13,788,022 |
RGD:6480464 |
CTD |
| G |
Hspa8 |
heat shock 70kDa protein 8 |
|
decreases expression |
ISO |
8 |
43,784,035 |
43,787,760 |
RGD:6480464 |
CTD |
| G |
Icam1 |
intercellular adhesion molecule 1 |
|
multiple interactions |
ISO |
8 |
20,040,177 |
20,051,939 |
RGD:6480464 |
CTD |
| G |
Icam1 |
intercellular adhesion molecule 1 |
|
multiple interactions |
ISO |
8 |
20,040,177 |
20,051,939 |
RGD:6480464 |
CTD |
| G |
Idh3a |
isocitrate dehydrogenase 3 (NAD+) alpha |
|
decreases expression |
ISO |
8 |
58,135,412 |
58,156,019 |
RGD:6480464 |
CTD |
| G |
Ifng |
interferon gamma |
|
multiple interactions |
EXP |
7 |
57,621,756 |
57,625,792 |
RGD:6480464 |
CTD |
| G |
Il10 |
interleukin 10 |
|
multiple interactions |
ISO |
13 |
43,953,900 |
43,957,766 |
RGD:6480464 |
CTD |
| G |
Il1b |
interleukin 1 beta |
|
multiple interactions |
ISO |
3 |
116,964,422 |
116,970,867 |
RGD:6480464 |
CTD |
| G |
Il1b |
interleukin 1 beta |
|
multiple interactions |
EXP |
3 |
116,964,422 |
116,970,867 |
RGD:6480464 |
CTD |
| G |
Il4 |
interleukin 4 |
|
decreases expression |
ISO |
10 |
39,074,582 |
39,080,134 |
RGD:6480464 |
CTD |
| G |
Ins1 |
insulin 1 |
|
multiple interactions |
EXP |
1 |
258,001,134 |
258,001,688 |
RGD:6480464 |
CTD |
| G |
Jun |
jun proto-oncogene |
|
multiple interactions |
ISO |
5 |
115,358,166 |
115,361,259 |
RGD:6480464 |
CTD |
| G |
Kdm3a |
lysine (K)-specific demethylase 3A |
|
increases expression |
ISO |
4 |
104,866,501 |
104,911,355 |
RGD:6480464 |
CTD |
| G |
Lep |
leptin |
|
increases expression |
ISO |
4 |
55,943,837 |
55,945,938 |
RGD:6480464 |
CTD |
| G |
Lrrc26 |
leucine rich repeat containing 26 |
|
increases expression |
ISO |
3 |
3,452,457 |
3,453,783 |
RGD:6480464 |
CTD |
| G |
Ltbp1 |
latent transforming growth factor beta binding protein 1 |
|
decreases expression |
ISO |
6 |
19,942,626 |
20,355,084 |
RGD:6480464 |
CTD |
| G |
Mapk1 |
mitogen activated protein kinase 1 |
|
multiple interactions |
ISO |
11 |
85,968,732 |
86,030,387 |
RGD:6480464 |
CTD |
| G |
Mapk1 |
mitogen activated protein kinase 1 |
|
multiple interactions |
ISO |
11 |
85,968,732 |
86,030,387 |
RGD:6480464 |
CTD |
| G |
Mapk3 |
mitogen activated protein kinase 3 |
|
multiple interactions |
ISO |
1 |
185,935,044 |
185,941,245 |
RGD:6480464 |
CTD |
| G |
Mib1 |
mindbomb E3 ubiquitin protein ligase 1 |
|
increases expression |
ISO |
18 |
2,106,102 |
2,224,819 |
RGD:6480464 |
CTD |
| G |
Mmp1 |
matrix metallopeptidase 1 (interstitial collagenase) |
|
decreases expression |
ISO |
8 |
4,333,773 |
4,354,284 |
RGD:6480464 |
CTD |
| G |
Mmp9 |
matrix metallopeptidase 9 |
|
multiple interactions |
ISO |
3 |
155,985,473 |
155,993,433 |
RGD:6480464 |
CTD |
| G |
Neo1 |
neogenin 1 |
|
increases expression |
ISO |
8 |
62,681,481 |
62,789,841 |
RGD:6480464 |
CTD |
| G |
Nfkb1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
|
multiple interactions |
EXP |
2 |
233,091,013 |
233,187,501 |
RGD:6480464 |
CTD |
| G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
|
multiple interactions |
ISO |
6 |
75,729,302 |
75,732,475 |
RGD:6480464 |
CTD |
| G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
|
multiple interactions |
ISO |
6 |
75,729,302 |
75,732,475 |
RGD:6480464 |
CTD |
| G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
|
multiple interactions |
EXP |
6 |
75,729,302 |
75,732,475 |
RGD:6480464 |
CTD |
| G |
Nfkbib |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
|
multiple interactions |
ISO |
1 |
83,865,440 |
83,873,010 |
RGD:6480464 |
CTD |
| G |
Nos2 |
nitric oxide synthase 2, inducible |
|
multiple interactions |
ISO |
10 |
65,036,884 |
65,072,453 |
RGD:6480464 |
CTD |
| G |
Nos2 |
nitric oxide synthase 2, inducible |
|
multiple interactions |
ISO |
10 |
65,036,884 |
65,072,453 |
RGD:6480464 |
CTD |
| G |
Nos2 |
nitric oxide synthase 2, inducible |
|
multiple interactions |
EXP |
10 |
65,036,884 |
65,072,453 |
RGD:6480464 |
CTD |
| G |
Nos2 |
nitric oxide synthase 2, inducible |
|
multiple interactions |
ISO |
10 |
65,036,884 |
65,072,453 |
RGD:6480464 |
CTD |
| G |
Pank2 |
pantothenate kinase 2 |
|
decreases expression |
ISO |
3 |
118,970,527 |
119,004,728 |
RGD:6480464 |
CTD |
| G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
|
multiple interactions |
ISO |
13 |
96,309,670 |
96,341,486 |
RGD:6480464 |
CTD |
| G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
|
multiple interactions |
ISO |
13 |
96,309,670 |
96,341,486 |
RGD:6480464 |
CTD |
| G |
Pgr |
progesterone receptor |
|
affects binding |
ISO |
8 |
5,784,717 |
5,845,901 |
RGD:6480464 |
CTD |
| G |
Pgr |
progesterone receptor |
|
multiple interactions |
ISO |
8 |
5,784,717 |
5,845,901 |
RGD:6480464 |
CTD |
| G |
Pkmyt1 |
protein kinase, membrane associated tyrosine/threonine 1 |
|
decreases expression |
ISO |
10 |
12,982,319 |
12,993,706 |
RGD:6480464 |
CTD |
| G |
Polr2h |
polymerase (RNA) II (DNA directed) polypeptide H |
|
increases expression |
ISO |
11 |
82,421,657 |
82,426,105 |
RGD:6480464 |
CTD |
| G |
Pparg |
peroxisome proliferator-activated receptor gamma |
|
multiple interactions |
ISO |
4 |
151,492,220 |
151,617,331 |
RGD:6480464 |
CTD |
| G |
Pparg |
peroxisome proliferator-activated receptor gamma |
|
decreases expression |
ISO |
4 |
151,492,220 |
151,617,331 |
RGD:6480464 |
CTD |
| G |
Prkaa1 |
protein kinase, AMP-activated, alpha 1 catalytic subunit |
|
multiple interactions |
ISO |
2 |
54,327,821 |
54,360,462 |
RGD:6480464 |
CTD |
| G |
Prpsap1 |
phosphoribosyl pyrophosphate synthetase-associated protein 1 |
|
increases expression |
ISO |
10 |
106,582,381 |
106,604,072 |
RGD:6480464 |
CTD |
| G |
Psca |
prostate stem cell antigen |
|
decreases expression |
ISO |
7 |
112,823,862 |
112,835,190 |
RGD:6480464 |
CTD |
| G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
|
multiple interactions |
ISO |
13 |
64,427,288 |
64,432,978 |
RGD:6480464 |
CTD |
| G |
Ranbp10 |
RAN binding protein 10 |
|
increases expression |
ISO |
19 |
35,601,078 |
35,661,711 |
RGD:6480464 |
CTD |
| G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
|
multiple interactions |
ISO |
1 |
208,262,669 |
208,273,148 |
RGD:6480464 |
CTD |
| G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
|
increases expression |
ISO |
1 |
208,262,669 |
208,273,148 |
RGD:6480464 |
CTD |
| G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
|
multiple interactions |
EXP |
1 |
208,262,669 |
208,273,148 |
RGD:6480464 |
CTD |
| G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
|
multiple interactions |
ISO |
1 |
208,262,669 |
208,273,148 |
RGD:6480464 |
CTD |
| G |
Rps6kb1 |
ribosomal protein S6 kinase, polypeptide 1 |
|
decreases expression |
ISO |
10 |
76,657,024 |
76,698,088 |
RGD:6480464 |
CTD |
| G |
Sele |
selectin E |
|
multiple interactions |
ISO |
13 |
79,813,455 |
79,822,845 |
RGD:6480464 |
CTD |
| G |
Slain2 |
SLAIN motif family, member 2 |
|
increases expression |
ISO |
14 |
37,639,681 |
37,708,306 |
RGD:6480464 |
CTD |
| G |
Slc16a1 |
solute carrier family 16, member 1 (monocarboxylic acid transporter 1) |
|
multiple interactions |
EXP |
2 |
199,860,341 |
199,879,856 |
RGD:6480464 |
CTD |
| G |
Sod1 |
superoxide dismutase 1, soluble |
|
decreases expression |
ISO |
11 |
29,810,766 |
29,816,342 |
RGD:6480464 |
CTD |
| G |
Sptbn1 |
spectrin, beta, non-erythrocytic 1 |
|
increases expression |
ISO |
14 |
111,076,741 |
111,246,286 |
RGD:6480464 |
CTD |
| G |
Sult1a1 |
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
|
increases sulfation |
ISO |
1 |
185,829,205 |
185,832,725 |
RGD:6480464 |
CTD |
| G |
Sult1e1 |
sulfotransferase family 1E, estrogen-preferring, member 1 |
|
multiple interactions |
ISO |
14 |
21,948,475 |
21,965,541 |
RGD:6480464 |
CTD |
| G |
Tecr |
trans-2,3-enoyl-CoA reductase |
|
increases expression |
ISO |
19 |
26,232,602 |
26,259,289 |
RGD:6480464 |
CTD |
| G |
Tfpt |
TCF3 (E2A) fusion partner |
|
decreases expression |
ISO |
1 |
63,901,368 |
63,910,301 |
RGD:6480464 |
CTD |
| G |
Tnf |
tumor necrosis factor |
|
multiple interactions |
ISO |
20 |
3,661,000 |
3,663,618 |
RGD:6480464 |
CTD |
| G |
Tnf |
tumor necrosis factor |
|
multiple interactions |
ISO |
20 |
3,661,000 |
3,663,618 |
RGD:6480464 |
CTD |
| G |
Tnf |
tumor necrosis factor |
|
multiple interactions |
ISO |
20 |
3,661,000 |
3,663,618 |
RGD:6480464 |
CTD |
| G |
Tnf |
tumor necrosis factor |
|
multiple interactions |
ISO |
20 |
3,661,000 |
3,663,618 |
RGD:6480464 |
CTD |
| G |
Tnf |
tumor necrosis factor |
|
multiple interactions |
ISO |
20 |
3,661,000 |
3,663,618 |
RGD:6480464 |
CTD |
| G |
Tp53 |
tumor protein p53 |
|
multiple interactions |
ISO |
10 |
56,399,721 |
56,411,150 |
RGD:6480464 |
CTD |
| G |
Tp53 |
tumor protein p53 |
|
increases expression |
ISO |
10 |
56,399,721 |
56,411,150 |
RGD:6480464 |
CTD |
| G |
Tp63 |
tumor protein p63 |
|
increases expression |
ISO |
11 |
76,900,622 |
77,200,251 |
RGD:6480464 |
CTD |
| G |
Tp73 |
tumor protein p73 |
|
increases expression |
ISO |
5 |
170,848,979 |
171,078,739 |
RGD:6480464 |
CTD |
| G |
Tyr |
tyrosinase |
|
increases expression |
ISO |
1 |
143,641,257 |
143,746,315 |
RGD:6480464 |
CTD |
| G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
|
increases expression |
ISO |
9 |
87,091,241 |
87,098,362 |
RGD:6480464 |
CTD |
| G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
|
multiple interactions |
ISO |
9 |
87,091,241 |
87,098,362 |
RGD:6480464 |
CTD |
| G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
|
increases glucuronidation |
ISO |
9 |
87,091,241 |
87,098,362 |
RGD:6480464 |
CTD |
| G |
Ugt1a8 |
UDP glycosyltransferase 1 family, polypeptide A8 |
|
increases glucuronidation |
ISO |
9 |
87,017,029 |
87,098,362 |
RGD:6480464 |
CTD |
| G |
Ugt1a9 |
UDP glucuronosyltransferase 1 family, polypeptide A9 |
|
increases glucuronidation |
ISO |
9 |
86,986,915 |
87,098,362 |
RGD:6480464 |
CTD |
| G |
Ugt2b15 |
UDP glucuronosyltransferase 2 family, polypeptide B15 |
|
increases metabolic processing |
EXP |
14 |
22,346,334 |
22,366,860 |
RGD:6480464 |
CTD |
| G |
Ugt2b15 |
UDP glucuronosyltransferase 2 family, polypeptide B15 |
|
increases metabolic processing |
ISO |
14 |
22,346,334 |
22,366,860 |
RGD:6480464 |
CTD |
| G |
Usp48 |
ubiquitin specific peptidase 48 |
|
increases expression |
ISO |
5 |
156,351,117 |
156,418,283 |
RGD:6480464 |
CTD |
| G |
Utrn |
utrophin |
|
increases expression |
ISO |
1 |
7,099,840 |
7,614,980 |
RGD:6480464 |
CTD |
| G |
Vcam1 |
vascular cell adhesion molecule 1 |
|
multiple interactions |
ISO |
2 |
212,277,654 |
212,297,376 |
RGD:6480464 |
CTD |
| G |
Vegfa |
vascular endothelial growth factor A |
|
decreases expression |
ISO |
9 |
10,520,730 |
10,536,071 |
RGD:6480464 |
CTD |
| G |
Wisp2 |
WNT1 inducible signaling pathway protein 2 |
|
increases expression |
ISO |
3 |
154,748,977 |
154,760,324 |
RGD:6480464 |
CTD |
| G |
Wisp2 |
WNT1 inducible signaling pathway protein 2 |
|
multiple interactions |
ISO |
3 |
154,748,977 |
154,760,324 |
RGD:6480464 |
CTD |
| G |
Zcrb1 |
zinc finger CCHC-type and RNA binding motif 1 |
|
increases expression |
ISO |
7 |
131,852,634 |
131,865,971 |
RGD:6480464 |
CTD |
| G |
Zfp110 |
zinc finger protein 110 |
|
increases expression |
ISO |
1 |
72,735,178 |
72,750,419 |
RGD:6480464 |
CTD |
5,7-dihydroxy-4'-methoxyflavone
|
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
increases metabolic processing |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
|
decreases activity |
ISO |
8 |
61,439,062 |
61,447,861 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
increases metabolic processing |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
multiple interactions |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
|
multiple interactions |
ISO |
1 |
243,281,320 |
243,320,945 |
RGD:6480464 |
CTD |
| G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
|
multiple interactions |
ISO |
12 |
9,517,016 |
9,541,000 |
RGD:6480464 |
CTD |
scutellarein
|
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
decreases activity |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
|
affects metabolic processing |
ISO |
8 |
61,462,207 |
61,468,237 |
RGD:6480464 |
CTD |
| G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
|
affects metabolic processing |
ISO |
8 |
61,439,062 |
61,447,861 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
decreases activity |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
affects metabolic processing |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
| G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
multiple interactions |
ISO |
6 |
2,548,224 |
2,553,767 |
RGD:6480464 |
CTD |
scutellarin
|
| G |
App |
amyloid beta (A4) precursor protein |
|
multiple interactions |
EXP |
11 |
24,457,855 |
24,693,851 |
RGD:6480464 |
CTD |
| G |
Bcl2l1 |
Bcl2-like 1 |
|
multiple interactions |
EXP |
3 |
143,129,087 |
143,180,199 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
multiple interactions |
EXP |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Fgf2 |
fibroblast growth factor 2 |
|
decreases expression |
EXP |
2 |
123,893,314 |
123,947,136 |
RGD:6480464 |
CTD |
| G |
Nos2 |
nitric oxide synthase 2, inducible |
|
decreases expression |
EXP |
10 |
65,036,884 |
65,072,453 |
RGD:6480464 |
CTD |
| G |
Nos3 |
nitric oxide synthase 3, endothelial cell |
|
increases expression |
EXP |
4 |
6,158,847 |
6,179,441 |
RGD:6480464 |
CTD |
| G |
Pla2g2a |
phospholipase A2, group IIA (platelets, synovial fluid) |
|
affects activity |
ISO |
5 |
157,654,786 |
157,657,360 |
RGD:6480464 |
CTD |
| G |
Vegfa |
vascular endothelial growth factor A |
|
decreases expression |
EXP |
9 |
10,520,730 |
10,536,071 |
RGD:6480464 |
CTD |
Term paths to the root
|