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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions decreases expression |
EXP ISO |
Colistin results in decreased phosphorylation of AKT1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein] Colistin results in decreased expression of AKT1 protein modified form |
CTD |
PMID:28465020 PMID:35378205 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
Colistin results in increased expression of APAF1 mRNA; Colistin results in increased expression of APAF1 protein |
CTD |
PMID:34560125 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Atg12 |
autophagy related 12 |
increases expression |
ISO |
Colistin results in increased expression of ATG12 mRNA |
CTD |
PMID:35378205 |
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NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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G |
Atg5 |
autophagy related 5 |
increases expression |
ISO |
Colistin results in increased expression of ATG5 mRNA |
CTD |
PMID:35378205 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Atg9a |
autophagy related 9A |
increases expression |
ISO |
Colistin results in increased expression of ATG9A mRNA |
CTD |
PMID:35378205 |
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NCBI chr 9:76,677,403...76,688,050
Ensembl chr 9:76,677,404...76,687,986
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
EXP ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein] Colistin results in increased expression of BAX mRNA; Colistin results in increased expression of BAX protein |
CTD |
PMID:28465020 PMID:28842171 PMID:34560125 PMID:35378205 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions increases phosphorylation |
EXP ISO |
Colistin results in decreased expression of BCL2 protein Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2 protein] Colistin results in decreased expression of BCL2 mRNA; Colistin results in decreased expression of BCL2 protein Colistin results in increased phosphorylation of BCL2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; [Colistin co-treated with Anisomycin] results in increased phosphorylation of BCL2 protein; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein] |
CTD |
PMID:28465020 PMID:28842171 PMID:30138604 PMID:34560125 PMID:35378205 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression |
ISO |
Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2L1 protein] |
CTD |
PMID:35378205 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Becn1 |
beclin 1 |
increases expression multiple interactions |
EXP ISO |
Colistin results in increased expression of BECN1 mRNA; Colistin results in increased expression of BECN1 protein Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein] |
CTD |
PMID:28842171 PMID:30318960 PMID:35378205 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases expression increases cleavage |
EXP ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; [Colistin co-treated with Anisomycin] results in increased cleavage of CASP3 protein; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Colistin results in increased activity of and results in increased cleavage of CASP3 protein; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 protein]; rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein] Colistin results in increased activity of CASP3 protein 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Colistin results in increased activity of CASP3 protein]; MitoTEMPO inhibits the reaction [Colistin results in increased activity of CASP3 protein]; setanaxib inhibits the reaction [Colistin results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP3 protein] Colistin results in increased cleavage of CASP3 protein Colistin results in increased expression of CASP3 mRNA; Colistin results in increased expression of CASP3 protein |
CTD |
PMID:28465020 PMID:28842171 PMID:30138604 PMID:30273961 PMID:30318960 PMID:34560125 PMID:35378205 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
Colistin results in increased cleavage of CASP8 protein |
CTD |
PMID:34560125 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases expression increases activity multiple interactions increases cleavage |
ISO |
Colistin results in increased expression of CASP9 mRNA Colistin results in increased activity of CASP9 protein 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Colistin results in increased activity of CASP9 protein]; MitoTEMPO inhibits the reaction [Colistin results in increased activity of CASP9 protein]; setanaxib inhibits the reaction [Colistin results in increased activity of CASP9 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP9 protein] Colistin results in increased cleavage of CASP9 protein |
CTD |
PMID:34560125 PMID:35378205 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression decreases activity multiple interactions |
EXP ISO |
Colistin results in decreased expression of CAT protein Colistin results in decreased activity of CAT protein chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein] |
CTD |
PMID:30138604 PMID:30273961 PMID:35378205 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Dgcr8 |
DGCR8 microprocessor complex subunit |
decreases expression |
ISO |
Colistin results in decreased expression of DGCR8 protein |
CTD |
PMID:34560125 |
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NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242
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G |
Hmox1 |
heme oxygenase 1 |
decreases expression |
ISO |
Colistin results in decreased expression of HMOX1 mRNA; Colistin results in decreased expression of HMOX1 protein |
CTD |
PMID:34560125 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein] |
CTD |
PMID:30138604 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
increases expression |
ISO |
Colistin results in increased expression of KEAP1 mRNA; Colistin results in increased expression of KEAP1 protein |
CTD |
PMID:34560125 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases expression |
EXP |
chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] Colistin results in increased expression of MAP1LC3B mRNA; Colistin results in increased expression of MAP1LC3B protein |
CTD |
PMID:30273961 PMID:30318960 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mettl3 |
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit |
decreases expression |
ISO |
Colistin results in decreased expression of METTL3 mRNA; Colistin results in decreased expression of METTL3 protein |
CTD |
PMID:34560125 |
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NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041
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G |
Mrgprx2 |
MAS related GPR family member X2 |
multiple interactions increases response to substance |
ISO |
MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein] MRGPRX2 protein results in increased susceptibility to Colistin |
CTD |
PMID:31132327 |
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NCBI chr 1:98,116,192...98,135,534
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases expression |
ISO |
Colistin results in decreased expression of MTOR protein modified form |
CTD |
PMID:35378205 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Ndufb8 |
NADH:ubiquinone oxidoreductase subunit B8 |
decreases expression |
ISO |
Colistin results in decreased expression of NDUFB8 protein |
CTD |
PMID:35378205 |
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NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases expression |
ISO |
Colistin results in decreased expression of NFE2L2 protein |
CTD |
PMID:34560125 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Ngf |
nerve growth factor |
multiple interactions |
EXP |
NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] |
CTD |
PMID:30318960 |
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NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Nox4 |
NADPH oxidase 4 |
increases expression |
ISO |
Colistin results in increased expression of NOX4 mRNA; Colistin results in increased expression of NOX4 protein |
CTD |
PMID:35378205 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Oga |
O-GlcNAcase |
increases secretion multiple interactions |
ISO |
Colistin results in increased secretion of OGA protein MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein] |
CTD |
PMID:31132327 |
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NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
EXP |
[Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein |
CTD |
PMID:28842171 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Sdhb |
succinate dehydrogenase complex iron sulfur subunit B |
decreases expression |
ISO |
Colistin results in decreased expression of SDHB protein |
CTD |
PMID:35378205 |
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NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
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G |
Sqstm1 |
sequestosome 1 |
increases degradation multiple interactions |
EXP |
Colistin results in increased degradation of SQSTM1 protein Anisomycin promotes the reaction [Colistin results in increased degradation of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein] |
CTD |
PMID:28842171 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
ISO |
Colistin results in increased expression of TGFB1 mRNA; Colistin results in increased expression of TGFB1 protein |
CTD |
PMID:35378205 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
increases expression increases secretion multiple interactions |
EXP ISO |
Colistin results in increased expression of TNF protein Colistin results in increased secretion of TNF protein Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein] |
CTD |
PMID:30138604 PMID:31132327 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
EXP |
Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of TP53 protein] |
CTD |
PMID:28842171 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tsc2 |
TSC complex subunit 2 |
increases expression |
ISO |
Colistin results in increased expression of TSC2 protein |
CTD |
PMID:35378205 |
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NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
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G |
Uqcrc2 |
ubiquinol cytochrome c reductase core protein 2 |
decreases expression |
ISO |
Colistin results in decreased expression of UQCRC2 protein |
CTD |
PMID:35378205 |
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NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
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G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
increases expression multiple interactions |
ISO |
Polymyxin B results in increased expression of ALOX12 protein TP53 protein promotes the reaction [Polymyxin B results in increased expression of ALOX12 protein] |
CTD |
PMID:37088170 |
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NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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G |
Atf3 |
activating transcription factor 3 |
multiple interactions |
ISO |
Polymyxin B promotes the reaction [Particulate Matter results in increased expression of ATF3 mRNA] |
CTD |
PMID:21652769 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Ccl11 |
C-C motif chemokine ligand 11 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein] |
CTD |
PMID:26882889 |
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NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]] |
CTD |
PMID:21652769 PMID:26882889 PMID:28555929 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions decreases secretion |
ISO |
Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]]; Acetylcysteine promotes the reaction [Polymyxin B results in decreased secretion of CCL3 protein]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL3 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of CCL3 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine results in decreased secretion of CCL3 protein] |
CTD |
PMID:26882889 PMID:28555929 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL5 protein] Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein] |
CTD |
PMID:26882889 PMID:29348435 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein] |
CTD |
PMID:26882889 |
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NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Cd80 |
Cd80 molecule |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD80 protein] |
CTD |
PMID:14977963 |
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NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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G |
Cd86 |
CD86 molecule |
increases expression multiple interactions |
ISO |
Polymyxin B results in increased expression of CD86 protein Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD86 protein] Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein] |
CTD |
PMID:14977963 PMID:15671028 PMID:30944281 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions decreases expression |
ISO |
Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 protein] Polymyxin B results in decreased expression of CSF2 protein |
CTD |
PMID:31442584 |
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NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Csf3 |
colony stimulating factor 3 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein]; Polymyxin B promotes the reaction [Cadmium Chloride results in increased expression of CSF3 protein] |
CTD |
PMID:26790433 |
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NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of CXCL2 mRNA] |
CTD |
PMID:21652769 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[Polymyxin B co-treated with Particulate Matter] results in increased expression of CXCL1 protein; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CXCL1 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of CXCL1 mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]] |
CTD |
PMID:26882889 PMID:28555929 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Polymyxin B promotes the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:20801209 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
EXP |
Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP2C11 protein] |
CTD |
PMID:18079364 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] |
CTD |
PMID:18079364 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Fth1 |
ferritin heavy chain 1 |
decreases expression |
ISO |
Polymyxin B results in decreased expression of FTH1 protein |
CTD |
PMID:37088170 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [Alpha-Amanitin results in decreased expression of GAPDH mRNA] |
CTD |
PMID:26385100 |
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NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
Polymyxin B results in increased expression of GCLM mRNA |
CTD |
PMID:37088170 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gpnmb |
glycoprotein nmb |
increases secretion |
ISO |
Polymyxin B results in increased secretion of GPNMB protein |
CTD |
PMID:32905824 |
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NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] |
CTD |
PMID:30891624 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions decreases expression |
ISO |
baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]; SLC7A11 protein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of GPX4 protein] GPX4 protein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein] Polymyxin B results in decreased expression of GPX4 mRNA; Polymyxin B results in decreased expression of GPX4 protein |
CTD |
PMID:37088170 PMID:37354967 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
increases secretion |
ISO |
Polymyxin B results in increased secretion of HAVCR1 protein |
CTD |
PMID:32905824 |
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NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]; Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] |
CTD |
PMID:22014880 |
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NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
Polymyxin B inhibits the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]] baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of HMOX1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]] Polymyxin B results in increased expression of HMOX1 mRNA; Polymyxin B results in increased expression of HMOX1 protein |
CTD |
PMID:28555929 PMID:37088170 PMID:37354967 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein] |
CTD |
PMID:24080332 PMID:30944281 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of IL10 protein] |
CTD |
PMID:14977963 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:26882889 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] |
CTD |
PMID:9278343 PMID:26882889 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein] |
CTD |
PMID:26882889 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL1A mRNA] |
CTD |
PMID:21703343 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Polymyxin B inhibits the reaction [Vehicle Emissions results in increased secretion of IL1B protein] Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL1B protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of IL1B mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA] |
CTD |
PMID:14993811 PMID:18406506 PMID:26882889 PMID:27393915 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein] |
CTD |
PMID:26882889 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO EXP |
Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein] Dextran Sulfate inhibits the reaction [Polymyxin B results in decreased expression of IL6 protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of IL6 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]] Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of IL6] |
CTD |
PMID:8886760 PMID:12185005 PMID:20549640 PMID:21784459 PMID:26882889 PMID:28555929 PMID:31442584 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK1 protein Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]]; Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15671028 PMID:28555929 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Polymyxin B results in increased phosphorylation of and results in increased activity of MAPK3 protein Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]]; Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15671028 PMID:28555929 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp1 |
matrix metallopeptidase 1 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]; Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]] |
CTD |
PMID:18986645 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Polymyxin B inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein] |
CTD |
PMID:30891624 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mrgprx2 |
MAS related GPR family member X2 |
increases response to substance multiple interactions |
ISO |
MRGPRX2 protein results in increased susceptibility to Polymyxin B MRGPRX2 protein affects the reaction [Polymyxin B results in increased secretion of OGA protein] |
CTD |
PMID:31132327 |
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NCBI chr 1:98,116,192...98,135,534
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
[Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein; [Particulate Matter co-treated with Polymyxin B] results in increased secretion of MYD88 protein; MYD88 protein affects the reaction [[Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]] |
CTD |
PMID:28555929 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
Polymyxin B inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:12568917 PMID:23500011 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Oga |
O-GlcNAcase |
increases secretion multiple interactions |
ISO |
Polymyxin B results in increased secretion of OGA protein MRGPRX2 protein affects the reaction [Polymyxin B results in increased secretion of OGA protein] |
CTD |
PMID:31132327 |
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NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
baicalein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]; GPX4 protein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]; Polymyxin B affects the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]] Polymyxin B promotes the reaction [Particulate Matter results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21652769 PMID:23500011 PMID:27393915 PMID:28555929 PMID:37088170 PMID:37354967 More...
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rig1 |
RNA sensor RIG-1 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of RIGI mRNA] |
CTD |
PMID:27183587 |
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NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
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G |
Sele |
selectin E |
multiple interactions |
ISO |
Polymyxin B promotes the reaction [Particulate Matter results in increased expression of SELE mRNA] |
CTD |
PMID:21652769 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Sirt1 |
sirtuin 1 |
decreases expression multiple interactions |
ISO |
Polymyxin B results in decreased expression of SIRT1 protein baicalein inhibits the reaction [Polymyxin B results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]] |
CTD |
PMID:37354967 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Slc7a11 |
solute carrier family 7 member 11 |
decreases expression multiple interactions |
ISO |
Polymyxin B results in decreased expression of SLC7A11 protein baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]; SLC7A11 protein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of SLC7A11 protein] |
CTD |
PMID:37088170 PMID:37354967 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Tfrc |
transferrin receptor |
increases expression multiple interactions |
ISO |
Polymyxin B results in increased expression of TFRC mRNA; Polymyxin B results in increased expression of TFRC protein TP53 protein promotes the reaction [Polymyxin B results in increased expression of TFRC protein] |
CTD |
PMID:37088170 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] |
CTD |
PMID:22014880 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases secretion decreases expression |
ISO EXP |
Dextran Sulfate inhibits the reaction [Polymyxin B results in decreased expression of TNF protein]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]]; Polymyxin B inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Dust results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]] Polymyxin B inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Polymyxin B inhibits the reaction [Vehicle Emissions results in increased secretion of TNF protein] Polymyxin B inhibits the reaction [Particulate Matter results in increased expression of TNF] Polymyxin B results in increased secretion of TNF protein |
CTD |
PMID:8886760 PMID:12185005 PMID:18406506 PMID:26882889 PMID:28555929 PMID:29348435 PMID:31132327 PMID:31442584 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]; Polymyxin B results in increased expression of and results in increased acetylation of TP53 protein; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of GPX4 protein]; TP53 protein promotes the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]; TP53 protein promotes the reaction [Polymyxin B results in increased expression of ALOX12 protein]; TP53 protein promotes the reaction [Polymyxin B results in increased expression of TFRC protein] |
CTD |
PMID:37088170 PMID:37354967 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vegfa |
vascular endothelial growth factor A |
increases secretion |
ISO |
Polymyxin B results in increased secretion of VEGFA protein |
CTD |
PMID:32905824 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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