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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:colistin
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Accession:CHEBI:37943 term browser browse the term
Definition:A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.
Synonyms:related_synonym: Formula=C52H97N16O13R;   SMILES=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)CCC[C@@H](C*)C;   colistina;   colistine;   colistinum;   polymyxin E
 alt_id: CHEBI:34651;   CHEBI:472593;   CHEBI:560465;   CHEBI:566816;   CHEBI:596826;   CHEBI:597111;   CHEBI:600596;   CHEBI:659853
 xref: CAS:1066-17-7;   CAS:1264-72-8;   DrugBank:DB00803;   KEGG:C13768;   KEGG:D02138
 xref_mesh: MESH:D003091
 xref: PMID:15825037;   PMID:16931410;   PMID:17145797;   PMID:17562800;   PMID:17576842;   PMID:17606684;   PMID:17620384;   PMID:17646423;   PMID:17846127;   PMID:17876007;   PMID:18625681;   PMID:25322351;   PMID:26252512;   PMID:26415906;   PMID:26488563;   PMID:26730548;   PMID:27160031;   PMID:27411324;   PMID:27480806;   PMID:27524102;   PMID:27552304;   PMID:27684296;   PMID:27743779;   PMID:27790432;   PMID:27793510;   PMID:27891118;   PMID:27917926;   PMID:28018876;   PMID:28029008;   PMID:28215823;   PMID:28257552;   PMID:28267594;   PMID:28267779;   PMID:28300674;   PMID:28315729;   PMID:28321410


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colistin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
decreases expression		 EXP
ISO		 Colistin results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]
Colistin results in decreased expression of AKT1 protein modified form		 CTD PMID:28465020 PMID:35378205 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Colistin results in increased expression of APAF1 mRNA; Colistin results in increased expression of APAF1 protein CTD PMID:34560125 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atg12 autophagy related 12 increases expression ISO Colistin results in increased expression of ATG12 mRNA CTD PMID:35378205 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Colistin results in increased expression of ATG5 mRNA CTD PMID:35378205 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg9a autophagy related 9A increases expression ISO Colistin results in increased expression of ATG9A mRNA CTD PMID:35378205 NCBI chr 9:76,677,403...76,688,050
Ensembl chr 9:76,677,404...76,687,986 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]
Colistin results in increased expression of BAX mRNA; Colistin results in increased expression of BAX protein		 CTD PMID:28465020 PMID:28842171 PMID:34560125 PMID:35378205 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases phosphorylation		 EXP
ISO		 Colistin results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; [Colistin co-treated with Anisomycin] results in increased phosphorylation of BCL2 protein; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]
Colistin results in increased phosphorylation of BCL2 protein
Colistin results in decreased expression of BCL2 mRNA; Colistin results in decreased expression of BCL2 protein
Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2 protein]		 CTD PMID:28465020 PMID:28842171 PMID:30138604 PMID:34560125 PMID:35378205 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2L1 protein] CTD PMID:35378205 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 EXP
ISO		 Colistin results in increased expression of BECN1 mRNA; Colistin results in increased expression of BECN1 protein
Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]		 CTD PMID:28842171 PMID:30318960 PMID:35378205 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
increases activity		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; [Colistin co-treated with Anisomycin] results in increased cleavage of CASP3 protein; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Colistin results in increased activity of and results in increased cleavage of CASP3 protein; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 protein]; rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]
Colistin results in increased expression of CASP3 mRNA; Colistin results in increased expression of CASP3 protein
Colistin results in increased cleavage of CASP3 protein
Colistin results in increased activity of CASP3 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Colistin results in increased activity of CASP3 protein]; MitoTEMPO inhibits the reaction [Colistin results in increased activity of CASP3 protein]; setanaxib inhibits the reaction [Colistin results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP3 protein]		 CTD PMID:28465020 PMID:28842171 PMID:30138604 PMID:30273961 PMID:30318960 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO Colistin results in increased cleavage of CASP8 protein CTD PMID:34560125 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage
multiple interactions
increases activity		 ISO Colistin results in increased expression of CASP9 mRNA
Colistin results in increased cleavage of CASP9 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Colistin results in increased activity of CASP9 protein]; MitoTEMPO inhibits the reaction [Colistin results in increased activity of CASP9 protein]; setanaxib inhibits the reaction [Colistin results in increased activity of CASP9 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP9 protein]		 CTD PMID:34560125 PMID:35378205 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression
multiple interactions
decreases activity		 EXP
ISO		 Colistin results in decreased expression of CAT protein
chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]		 CTD PMID:30138604 PMID:30273961 PMID:35378205 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit decreases expression ISO Colistin results in decreased expression of DGCR8 protein CTD PMID:34560125 NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO Colistin results in decreased expression of HMOX1 mRNA; Colistin results in decreased expression of HMOX1 protein CTD PMID:34560125 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein] CTD PMID:30138604 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Colistin results in increased expression of KEAP1 mRNA; Colistin results in increased expression of KEAP1 protein CTD PMID:34560125 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 EXP chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein]
Colistin results in increased expression of MAP1LC3B mRNA; Colistin results in increased expression of MAP1LC3B protein		 CTD PMID:30273961 PMID:30318960 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Colistin results in decreased expression of METTL3 mRNA; Colistin results in decreased expression of METTL3 protein CTD PMID:34560125 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 multiple interactions
increases response to substance		 ISO MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein]
MRGPRX2 protein results in increased susceptibility to Colistin		 CTD PMID:31132327 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Colistin results in decreased expression of MTOR protein modified form CTD PMID:35378205 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Colistin results in decreased expression of NDUFB8 protein CTD PMID:35378205 NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression ISO Colistin results in decreased expression of NFE2L2 protein CTD PMID:34560125 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of BECN1 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of CASP3 protein]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B mRNA]; NGF protein inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] CTD PMID:30318960 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Colistin results in increased expression of NOX4 mRNA; Colistin results in increased expression of NOX4 protein CTD PMID:35378205 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Oga O-GlcNAcase increases secretion
multiple interactions		 ISO Colistin results in increased secretion of OGA protein
MRGPRX2 protein affects the reaction [Colistin results in increased secretion of OGA protein]		 CTD PMID:31132327 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein CTD PMID:28842171 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B decreases expression ISO Colistin results in decreased expression of SDHB protein CTD PMID:35378205 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sqstm1 sequestosome 1 increases degradation
multiple interactions		 EXP Colistin results in increased degradation of SQSTM1 protein
Anisomycin promotes the reaction [Colistin results in increased degradation of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein]		 CTD PMID:28842171 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Colistin results in increased expression of TGFB1 mRNA; Colistin results in increased expression of TGFB1 protein CTD PMID:35378205 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion		 EXP
ISO		 Colistin results in increased expression of TNF protein
Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]
Colistin results in increased secretion of TNF protein		 CTD PMID:30138604 PMID:31132327 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 EXP Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Colistin results in increased expression of TP53 protein] CTD PMID:28842171 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tsc2 TSC complex subunit 2 increases expression ISO Colistin results in increased expression of TSC2 protein CTD PMID:35378205 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression ISO Colistin results in decreased expression of UQCRC2 protein CTD PMID:35378205 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      biological role 19808
        antimicrobial agent 18166
          peptide antibiotic 1817
            colistin 34
              colistimethate 0
              colistimethate sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            heteroorganic entity 19484
                              organochalcogen compound 19248
                                organooxygen compound 19165
                                  carbon oxoacid 18633
                                    carboxylic acid 18630
                                      carboacyl group 17703
                                        univalent carboacyl group 17703
                                          carbamoyl group 17553
                                            carboxamide 17553
                                              peptide 11126
                                                cyclic peptide 8875
                                                  heterodetic cyclic peptide 1647
                                                    polymyxin 80
                                                      colistin A 34
                                                        colistin 34
                                                          colistimethate 0
                                                          colistimethate sodium 0
paths to the root