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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:retinoic acid signaling pathway
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Accession:PW:0001014 term browser browse the term
Definition:Retinoic acid, a vitamin A-derived metabolite, plays important roles in development and cell differentiation. All-trans retinoic acid (RA) binds to nuclear RA (RARs) and X (RXRs) receptor subtypes that once activated act as transcription factors.
Synonyms:exact_synonym: RA signaling pathway
 related_synonym: Signaling by Retinoic Acid;   retinoic acid receptor signaling pathway
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retinoic acid signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncoa1 nuclear receptor coactivator 1 ISO RGD PMID:19471584 RGD:6484676 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:19471584 RGD:6484676 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 ISO RGD PMID:19471584 RGD:6484676 NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631 		JBrowse link
G Ncoa6 nuclear receptor coactivator 6 IDA RGD PMID:10866662 RGD:633378 NCBI chr 3:164,351,062...164,422,079
Ensembl chr 3:164,351,062...164,421,991 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO RGD PMID:19471584 RGD:6484676 NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:19471584 RGD:6484676 NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 ISO RGD PMID:19471584 RGD:6484676 NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353 		JBrowse link
G Pramex1 PRAME like, X-linked 1 ISO RGD PMID:19471584 RGD:6484676 NCBI chr  X:102,862,457...102,867,725
Ensembl chr  X:102,861,881...102,870,708 		JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 ISO RGD PMID:19471584 RGD:6484676 NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921 		JBrowse link
G Rara retinoic acid receptor, alpha ISO RGD PMID:17132850 PMID:19471584 PMID:17320364 RGD:6484674, RGD:6484676, RGD:6484731 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160 		JBrowse link
G Rarb retinoic acid receptor, beta ISO RGD PMID:17132850 PMID:19471584 PMID:17320364 RGD:6484674, RGD:6484676, RGD:6484731 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040 		JBrowse link
G Rarg retinoic acid receptor, gamma ISO RGD PMID:17132850 PMID:19471584 PMID:17320364 RGD:6484674, RGD:6484676, RGD:6484731 NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:135,246,427...135,268,889 		JBrowse link
G Rxra retinoid X receptor alpha ISO RGD PMID:17132853 PMID:17320364 RGD:6484675, RGD:6484731 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Rxrb retinoid X receptor beta ISO RGD PMID:17132853 PMID:17320364 RGD:6484675, RGD:6484731 NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,818,709...4,825,359 		JBrowse link
G Rxrg retinoid X receptor gamma ISO RGD PMID:17132853 PMID:17320364 RGD:6484675, RGD:6484731 NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095 		JBrowse link
G Trim24 tripartite motif-containing 24 ISO RGD PMID:19471584 RGD:6484676 NCBI chr 4:67,534,240...67,659,014
Ensembl chr 4:67,534,335...67,684,226 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      transcription factor mediated signaling pathway 445
        retinoic acid signaling pathway 16
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      homeostasis pathway 1772
        organic chemical homeostasis pathway 767
          vitamin homeostasis 151
            vitamin A homeostasis 151
              retinoic acid signaling pathway 16
paths to the root