Adcy10 (adenylate cyclase 10) - Rat Genome Database

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Gene: Adcy10 (adenylate cyclase 10) Rattus norvegicus
Analyze
Symbol: Adcy10
Name: adenylate cyclase 10
RGD ID: 708450
Description: Enables ATPase binding activity; adenylate cyclase activity; and manganese ion binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of apoptotic process; and regulation of reactive oxygen species biosynthetic process. Located in several cellular components, including astrocyte end-foot; central region of growth cone; and neuronal cell body. Orthologous to human ADCY10 (adenylate cyclase 10); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenylate cyclase 10 (soluble); adenylate cyclase type 10; germ cell soluble adenylyl cyclase; LOC59320; Sac; soluble adenylyl cyclase; testicular soluble adenylyl cyclase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,280,595 - 80,366,939 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1380,284,295 - 80,366,926 (+)EnsemblGRCr8
mRatBN7.21377,747,752 - 77,833,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1377,768,468 - 77,833,951 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1380,364,714 - 80,453,344 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01381,668,713 - 81,757,332 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01378,914,792 - 79,003,063 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01383,701,952 - 83,787,010 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,721,300 - 83,787,018 (+)Ensemblrn6Rnor6.0
Rnor_5.01388,583,534 - 88,667,840 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41381,208,090 - 81,302,902 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1377,464,675 - 77,547,216 (+)NCBICelera
RGSC_v3.11381,222,277 - 81,317,089 (+)NCBI
Cytogenetic Map13q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cAMP biosynthetic process  (IDA,IEA,IMP,ISO)
cyclic nucleotide biosynthetic process  (IEA)
epithelial cilium movement involved in extracellular fluid movement  (IEA,ISO,ISS)
glucose catabolic process  (IMP)
intracellular signal transduction  (IEA)
mitochondrial ATP transmembrane transport  (IMP)
negative regulation of cardiac muscle cell contraction  (IMP)
negative regulation of mitochondrial membrane potential  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
neuron projection extension  (IMP)
neuron projection maintenance  (IMP)
neuron projection retraction  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of axon extension  (IMP)
positive regulation of cAMP-dependent protein kinase activity  (IMP)
positive regulation of cardiac muscle cell apoptotic process  (IMP)
positive regulation of cardiac muscle hypertrophy  (IMP)
positive regulation of glycogen catabolic process  (IMP)
positive regulation of intrinsic apoptotic signaling pathway  (IDA)
positive regulation of mitochondrial depolarization  (IMP)
positive regulation of ossification  (IMP)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IMP)
positive regulation of peptidyl-threonine phosphorylation  (IMP)
positive regulation of protein targeting to mitochondrion  (IMP)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IDA)
regulation of membrane repolarization  (IMP)
regulation of mitophagy  (IMP)
spermatid development  (IEP)
spermatogenesis  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. Appukuttan A, etal., Cardiovasc Res. 2012 Feb 1;93(2):340-9. doi: 10.1093/cvr/cvr306. Epub 2011 Nov 21.
2. Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase. Appukuttan A, etal., Cardiovasc Res. 2013 Sep 1;99(4):734-42. doi: 10.1093/cvr/cvt137. Epub 2013 May 31.
3. Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Buck J, etal., Proc Natl Acad Sci U S A 1999 Jan 5;96(1):79-84.
4. Inhibition of Intracellular Type 10 Adenylyl Cyclase Protects Cortical Neurons Against Reperfusion-Induced Mitochondrial Injury and Apoptosis. Chagtoo M, etal., Mol Neurobiol. 2018 Mar;55(3):2471-2482. doi: 10.1007/s12035-017-0473-y. Epub 2017 Apr 6.
5. Autoinhibitory regulation of soluble adenylyl cyclase. Chaloupka JA, etal., Mol Reprod Dev. 2006 Mar;73(3):361-8. doi: 10.1002/mrd.20409.
6. Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Choi HB, etal., Neuron. 2012 Sep 20;75(6):1094-104. doi: 10.1016/j.neuron.2012.08.032.
7. Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth. Corredor RG, etal., J Neurosci. 2012 May 30;32(22):7734-44. doi: 10.1523/JNEUROSCI.5288-11.2012.
8. The functional association between the sodium/bicarbonate cotransporter (NBC) and the soluble adenylyl cyclase (sAC) modulates cardiac contractility. Espejo MS, etal., Pflugers Arch. 2020 Jan;472(1):103-115. doi: 10.1007/s00424-019-02331-x. Epub 2019 Nov 22.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Regulation of AMPK activity by type 10 adenylyl cyclase: contribution to the mitochondrial biology, cellular redox and energy homeostasis. Jayarajan V, etal., Cell Mol Life Sci. 2019 Dec;76(24):4945-4959. doi: 10.1007/s00018-019-03152-y. Epub 2019 Jun 6.
11. Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. Kolodecik TR, etal., PLoS One. 2012;7(7):e41320. doi: 10.1371/journal.pone.0041320. Epub 2012 Jul 23.
12. Manganese ion dependent adenylate cyclase activity in rat testes: purification and properties. Kornblihtt AR, etal., Biochemistry. 1981 Mar 3;20(5):1262-7.
13. Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. Kumar S, etal., J Biol Chem. 2009 May 29;284(22):14760-8. Epub 2009 Mar 31.
14. Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. Martinez J, etal., J Neurosci. 2014 Jul 9;34(28):9281-9. doi: 10.1523/JNEUROSCI.1434-14.2014.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. Paunescu TG, etal., Am J Physiol Renal Physiol. 2008 Jan;294(1):F130-8. Epub 2007 Oct 24.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
24. Soluble adenylyl cyclase: A novel player in cardiac hypertrophy induced by isoprenaline or pressure overload. Schirmer I, etal., PLoS One. 2018 Feb 21;13(2):e0192322. doi: 10.1371/journal.pone.0192322. eCollection 2018.
25. Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. Stessin AM, etal., J Biol Chem. 2006 Jun 23;281(25):17253-8. Epub 2006 Apr 20.
26. The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function. Teodoro JS, etal., Int J Mol Sci. 2020 Jul 11;21(14):4896. doi: 10.3390/ijms21144896.
27. Pulsed electromagnetic fields promote bone formation by activating the sAC-cAMP-PKA-CREB signaling pathway. Wang YY, etal., J Cell Physiol. 2019 Mar;234(3):2807-2821. doi: 10.1002/jcp.27098. Epub 2018 Aug 1.
28. Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Wu KY, etal., Nat Neurosci. 2006 Oct;9(10):1257-64. Epub 2006 Sep 10.
29. Expression of the soluble adenylyl cyclase during rat spermatogenesis: evidence for cytoplasmic sites of cAMP production in germ cells. Xie F and Conti M, Dev Biol. 2004 Jan 1;265(1):196-206. doi: 10.1016/j.ydbio.2003.09.020.
Additional References at PubMed
PMID:12609998   PMID:14512417   PMID:15659711   PMID:17591988   PMID:19144954   PMID:23686854   PMID:24567411   PMID:34800366  


Genomics

Comparative Map Data
Adcy10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,280,595 - 80,366,939 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1380,284,295 - 80,366,926 (+)EnsemblGRCr8
mRatBN7.21377,747,752 - 77,833,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1377,768,468 - 77,833,951 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1380,364,714 - 80,453,344 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01381,668,713 - 81,757,332 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01378,914,792 - 79,003,063 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01383,701,952 - 83,787,010 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,721,300 - 83,787,018 (+)Ensemblrn6Rnor6.0
Rnor_5.01388,583,534 - 88,667,840 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41381,208,090 - 81,302,902 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1377,464,675 - 77,547,216 (+)NCBICelera
RGSC_v3.11381,222,277 - 81,317,089 (+)NCBI
Cytogenetic Map13q23NCBI
ADCY10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,809,386 - 167,914,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,809,386 - 167,914,215 (-)Ensemblhg38GRCh38
GRCh371167,778,623 - 167,883,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,045,506 - 166,149,964 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341164,510,540 - 164,614,998NCBI
Celera1140,887,888 - 140,992,712 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1139,024,896 - 139,129,092 (-)NCBIHuRef
CHM1_11169,200,865 - 169,305,664 (-)NCBICHM1_1
T2T-CHM13v2.01167,160,872 - 167,265,599 (-)NCBIT2T-CHM13v2.0
Adcy10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,309,114 - 165,404,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,312,752 - 165,404,343 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381165,483,518 - 165,576,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,485,183 - 165,576,774 (+)Ensemblmm10GRCm38
MGSCv371167,415,314 - 167,506,904 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361167,321,858 - 167,413,448 (+)NCBIMGSCv36mm8
Celera1167,931,319 - 168,021,551 (+)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map172.83NCBI
Adcy10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554629,207,314 - 9,278,621 (+)Ensembl
ChiLan1.0NW_0049554629,196,984 - 9,278,850 (+)NCBIChiLan1.0ChiLan1.0
ADCY10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,848,277 - 81,957,079 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1181,516,261 - 81,625,530 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01143,239,576 - 143,404,038 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,023,671 - 147,129,705 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,023,671 - 147,129,705 (-)EnsemblpanPan2panpan1.1
ADCY10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1730,576,445 - 30,660,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl730,577,591 - 30,660,926 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha730,114,468 - 30,197,885 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0730,395,203 - 30,479,360 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl730,395,909 - 30,479,360 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1730,235,622 - 30,319,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0730,266,955 - 30,350,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0730,505,414 - 30,588,892 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adcy10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344100,415,703 - 100,483,395 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,274,154 - 18,330,173 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648118,274,158 - 18,330,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl483,098,290 - 83,205,454 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1483,103,768 - 83,205,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2490,773,869 - 90,880,759 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12561,129,837 - 61,228,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2561,140,293 - 61,230,117 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605562,864,231 - 62,951,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248265,845,001 - 5,897,497 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248265,844,868 - 5,897,541 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Adcy10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11044,622,333 - 44,686,978 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adcy10
363 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000004326
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
BF390833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21377,754,938 - 77,755,111 (+)MAPPERmRatBN7.2
Rnor_6.01383,707,768 - 83,707,940NCBIRnor6.0
Rnor_5.01388,587,226 - 88,587,398UniSTSRnor5.0
RGSC_v3.41381,211,716 - 81,211,888UniSTSRGSC3.4
Celera1377,468,305 - 77,468,477UniSTS
RH 3.4 Map13478.4UniSTS
Cytogenetic Map13q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 66 160 91 90 59 66 59 6 318 165 11 139 73 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF081941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000082677   ⟹   ENSRNOP00000072356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1380,284,295 - 80,366,926 (+)Ensembl
mRatBN7.2 Ensembl1377,768,468 - 77,833,951 (+)Ensembl
Rnor_6.0 Ensembl1383,721,300 - 83,787,018 (+)Ensembl
RefSeq Acc Id: NM_021684   ⟹   NP_067716
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,284,316 - 80,366,939 (+)NCBI
mRatBN7.21377,751,312 - 77,833,952 (+)NCBI
Rnor_6.01383,704,139 - 83,787,002 (+)NCBI
Rnor_5.01388,583,534 - 88,667,840 (+)NCBI
RGSC_v3.41381,208,090 - 81,302,902 (+)RGD
Celera1377,464,675 - 77,547,216 (+)RGD
Sequence:
RefSeq Acc Id: XM_008769677   ⟹   XP_008767899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,366,932 (+)NCBI
mRatBN7.21377,747,752 - 77,833,925 (+)NCBI
Rnor_6.01383,701,952 - 83,787,010 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769678   ⟹   XP_008767900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,366,932 (+)NCBI
mRatBN7.21377,747,752 - 77,833,925 (+)NCBI
Rnor_6.01383,701,952 - 83,787,010 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091049   ⟹   XP_038946977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,309,936 - 80,366,932 (+)NCBI
mRatBN7.21377,776,945 - 77,833,945 (+)NCBI
RefSeq Acc Id: XM_039091050   ⟹   XP_038946978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,321,195 - 80,366,932 (+)NCBI
mRatBN7.21377,788,204 - 77,833,945 (+)NCBI
RefSeq Acc Id: XM_039091051   ⟹   XP_038946979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,321,195 - 80,366,932 (+)NCBI
mRatBN7.21377,788,204 - 77,833,945 (+)NCBI
RefSeq Acc Id: XM_039091052   ⟹   XP_038946980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,330,320 - 80,366,932 (+)NCBI
mRatBN7.21377,797,328 - 77,833,945 (+)NCBI
RefSeq Acc Id: XM_063272564   ⟹   XP_063128634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,366,932 (+)NCBI
RefSeq Acc Id: XM_063272565   ⟹   XP_063128635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,366,932 (+)NCBI
RefSeq Acc Id: XM_063272566   ⟹   XP_063128636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,358,114 (+)NCBI
RefSeq Acc Id: XM_063272567   ⟹   XP_063128637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,351,352 (+)NCBI
RefSeq Acc Id: XM_063272568   ⟹   XP_063128638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,334,546 - 80,366,932 (+)NCBI
RefSeq Acc Id: NP_067716   ⟸   NM_021684
- UniProtKB: Q9Z286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767899   ⟸   XM_008769677
- Peptide Label: isoform X1
- UniProtKB: Q9Z286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767900   ⟸   XM_008769678
- Peptide Label: isoform X1
- UniProtKB: Q9Z286 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072356   ⟸   ENSRNOT00000082677
RefSeq Acc Id: XP_038946977   ⟸   XM_039091049
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946978   ⟸   XM_039091050
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946979   ⟸   XM_039091051
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946980   ⟸   XM_039091052
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063128635   ⟸   XM_063272565
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128634   ⟸   XM_063272564
- Peptide Label: isoform X1
- UniProtKB: Q9Z286 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128636   ⟸   XM_063272566
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128637   ⟸   XM_063272567
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063128638   ⟸   XM_063272568
- Peptide Label: isoform X9
- UniProtKB: A6IDH3 (UniProtKB/TrEMBL)
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z286-F1-model_v2 AlphaFold Q9Z286 1-1608 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708450 AgrOrtholog
BioCyc Gene G2FUF-17567 BioCyc
Ensembl Genes ENSRNOG00000053410 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082677 ENTREZGENE
  ENSRNOT00000082677.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  Adenylate_cyclase_typ10 UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:59320 UniProtKB/Swiss-Prot
NCBI Gene 59320 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 10 UniProtKB/Swiss-Prot
  TESTICULAR SOLUBLE ADENYLYL CYCLASE UniProtKB/Swiss-Prot
Pfam Guanylate_cyc UniProtKB/Swiss-Prot
PhenoGen Adcy10 PhenoGen
PIRSF Soluble_adenylyl_cyclase UniProtKB/Swiss-Prot
PROSITE GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053410 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
UniProt A6IDH3 ENTREZGENE, UniProtKB/TrEMBL
  ADCYA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Adcy10  adenylate cyclase 10  Adcy10  adenylate cyclase 10 (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adcy10  adenylate cyclase 10 (soluble)  Adcy10  adenylate cyclase 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Adcy10  adenylate cyclase 10  Adcy10  adenylate cyclase 10 (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Adcy10  adenylate cyclase 10 (soluble)      Symbol and Name updated 1299863 APPROVED
2005-09-30 LOC59320        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed preferentially in testis 1299450