Adcy10 (adenylate cyclase 10) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Adcy10 (adenylate cyclase 10) Ictidomys tridecemlineatus
Analyze
Symbol: Adcy10
Name: adenylate cyclase 10
RGD ID: 12639488
Description: ENCODES a protein that exhibits adenylate cyclase activity (ortholog); ATPase binding (ortholog); manganese ion binding (ortholog); INVOLVED IN cAMP biosynthetic process (ortholog); glucose catabolic process (ortholog); mitochondrial ATP transmembrane transport (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Breast Cancer, Familial (ortholog); Cardiomegaly (ortholog); cholangiocarcinoma (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); astrocyte end-foot (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenylate cyclase 10, soluble; adenylate cyclase type 10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mIctTri1.hap1 - mIctTri1.hap1 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1103,255,590 - 3,325,130 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024409344100,415,703 - 100,483,395 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,274,154 - 18,330,173 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648118,274,158 - 18,330,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0



Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cAMP biosynthetic process  (IEA,ISO)
cellular response to carbon dioxide  (IEA)
cyclic nucleotide biosynthetic process  (IEA)
epithelial cilium movement involved in extracellular fluid movement  (IEA)
glucose catabolic process  (ISO)
intracellular signal transduction  (IEA)
mitochondrial ATP transmembrane transport  (ISO)
negative regulation of cardiac muscle cell contraction  (ISO)
negative regulation of mitochondrial membrane potential  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
neuron projection extension  (ISO)
neuron projection maintenance  (ISO)
neuron projection retraction  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cAMP-dependent protein kinase activity  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of glycogen catabolic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of ossification  (ISO)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein localization to mitochondrion  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
regulation of intracellular pH  (IEA)
regulation of membrane repolarization  (ISO)
regulation of mitophagy  (ISO)
spermatid development  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adcy10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1103,255,590 - 3,325,130 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024409344100,415,703 - 100,483,395 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,274,154 - 18,330,173 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648118,274,158 - 18,330,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,809,386 - 167,914,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,809,098 - 167,914,215 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371167,778,623 - 167,883,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,045,506 - 166,149,964 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341164,510,540 - 164,614,998NCBI
Celera1140,887,888 - 140,992,712 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1139,024,896 - 139,129,092 (-)NCBIHuRef
CHM1_11169,200,865 - 169,305,664 (-)NCBICHM1_1
T2T-CHM13v2.01167,160,872 - 167,265,599 (-)NCBIT2T-CHM13v2.0
Adcy10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,309,114 - 165,404,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,312,752 - 165,404,344 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381165,483,518 - 165,576,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,485,183 - 165,576,774 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371167,415,314 - 167,506,904 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361167,321,858 - 167,413,448 (+)NCBIMGSCv36mm8
Celera1167,931,319 - 168,021,551 (+)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map172.83NCBI
Adcy10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,280,595 - 80,366,939 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1380,284,295 - 80,366,926 (+)EnsemblGRCr8
mRatBN7.21377,747,752 - 77,833,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1377,768,468 - 77,833,951 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1380,364,714 - 80,453,344 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01381,668,713 - 81,757,332 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01378,914,792 - 79,003,063 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1379,654,127 - 79,736,271 (+)NCBI
Lyon_Normotensive1379,875,633 - 79,958,200 (+)NCBI
Lyon_Hypertensive1379,815,198 - 79,897,759 (+)NCBI
F344_StmMcwi1379,861,147 - 79,943,293 (+)NCBI
Rnor_6.01383,701,952 - 83,787,010 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,721,300 - 83,787,018 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01388,583,534 - 88,667,840 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41381,208,090 - 81,302,902 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1377,464,675 - 77,547,216 (+)NCBICelera
RGSC_v3.11381,222,277 - 81,317,089 (+)NCBI
Cytogenetic Map13q23NCBI
Adcy10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554629,207,314 - 9,278,621 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554629,196,984 - 9,278,850 (+)NCBIChiLan1.0ChiLan1.0
ADCY10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,848,277 - 81,957,079 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1181,516,261 - 81,625,530 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01143,239,576 - 143,404,038 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,023,671 - 147,129,705 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,023,671 - 147,129,705 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
ADCY10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1730,576,445 - 30,660,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl730,577,591 - 30,660,926 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha730,114,468 - 30,197,885 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0730,395,203 - 30,479,360 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl730,395,909 - 30,479,360 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1730,235,622 - 30,319,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0730,266,955 - 30,350,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0730,505,414 - 30,588,892 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
ADCY10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl483,098,290 - 83,205,454 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1483,103,768 - 83,205,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2490,773,869 - 90,880,759 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12561,755,553 - 61,843,930 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366605562,864,231 - 62,951,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.12561,129,837 - 61,228,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2561,140,293 - 61,230,117 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Adcy10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248265,844,868 - 5,897,541 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248265,845,001 - 5,897,497 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Adcy10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11044,622,333 - 44,686,978 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005319843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040278364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040278365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040278366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040278367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040278368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040278369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040278370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040278371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040278372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_078022253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_078022254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_078022255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_078022256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_078022257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_078022258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_078022259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_013426324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JBPVTT010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000003282   ⟹   ENSSTOP00000002934
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648118,274,154 - 18,330,173 (+)Ensembl
RefSeq Acc Id: XM_078022253   ⟹   XP_077878379
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1103,255,590 - 3,325,130 (-)NCBI
RefSeq Acc Id: XM_078022254   ⟹   XP_077878380
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1103,255,590 - 3,325,130 (-)NCBI
RefSeq Acc Id: XM_078022255   ⟹   XP_077878381
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1103,255,590 - 3,325,130 (-)NCBI
RefSeq Acc Id: XM_078022256   ⟹   XP_077878382
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1103,255,590 - 3,325,130 (-)NCBI
RefSeq Acc Id: XM_078022257   ⟹   XP_077878383
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1103,255,590 - 3,308,388 (-)NCBI
RefSeq Acc Id: XM_078022258   ⟹   XP_077878384
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1103,255,590 - 3,308,412 (-)NCBI
RefSeq Acc Id: XM_078022259   ⟹   XP_077878385
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1103,255,590 - 3,301,173 (-)NCBI
RefSeq Acc Id: XR_013426324
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap1103,262,802 - 3,325,130 (-)NCBI
Ensembl Acc Id: ENSSTOP00000002934   ⟸   ENSSTOT00000003282
RefSeq Acc Id: XP_077878380   ⟸   XM_078022254
- Peptide Label: isoform X1
- UniProtKB: I3M1Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_077878379   ⟸   XM_078022253
- Peptide Label: isoform X1
- UniProtKB: I3M1Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_077878381   ⟸   XM_078022255
- Peptide Label: isoform X2
- UniProtKB: I3M1Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_077878382   ⟸   XM_078022256
- Peptide Label: isoform X3
- UniProtKB: I3M1Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_077878384   ⟸   XM_078022258
- Peptide Label: isoform X5
- UniProtKB: I3M1Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_077878383   ⟸   XM_078022257
- Peptide Label: isoform X4
- UniProtKB: I3M1Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_077878385   ⟸   XM_078022259
- Peptide Label: isoform X6
- UniProtKB: I3M1Z8 (UniProtKB/TrEMBL)
Protein Domains
Guanylate cyclase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003252 Ensembl, UniProtKB/TrEMBL
  ENSSTOG00015016317 ENTREZGENE
Ensembl Transcript ENSSTOT00000003282.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
NCBI Gene Adcy10 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 10 UniProtKB/TrEMBL
  TESTICULAR SOLUBLE ADENYLYL CYCLASE UniProtKB/TrEMBL
Pfam Guanylate_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF55073 UniProtKB/TrEMBL
UniProt I3M1Z8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-04 Adcy10  adenylate cyclase 10    adenylate cyclase 10, soluble  Symbol and/or name change 5135510 APPROVED