RGD Reference Report - Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. - Rat Genome Database

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Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.

Authors: Choi, Hyun B  Gordon, Grant R J  Zhou, Ning  Tai, Chao  Rungta, Ravi L  Martinez, Jennifer  Milner, Teresa A  Ryu, Jae K  McLarnon, James G  Tresguerres, Martin  Levin, Lonny R  Buck, Jochen  MacVicar, Brian A 
Citation: Choi HB, etal., Neuron. 2012 Sep 20;75(6):1094-104. doi: 10.1016/j.neuron.2012.08.032.
RGD ID: 329412477
Pubmed: PMID:22998876   (View Abstract at PubMed)
PMCID: PMC3630998   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuron.2012.08.032   (Journal Full-text)

Astrocytes are proposed to participate in brain energy metabolism by supplying substrates to neurons from their glycogen stores and from glycolysis. However, the molecules involved in metabolic sensing and the molecular pathways responsible for metabolic coupling between different cell types in the brain are not fully understood. Here we show that a recently cloned bicarbonate (HCO₃⁻) sensor, soluble adenylyl cyclase (sAC), is highly expressed in astrocytes and becomes activated in response to HCO₃⁻ entry via the electrogenic NaHCO₃ cotransporter (NBC). Activated sAC increases intracellular cAMP levels, causing glycogen breakdown, enhanced glycolysis, and the release of lactate into the extracellular space, which is subsequently taken up by neurons for use as an energy substrate. This process is recruited over a broad physiological range of [K⁺](ext) and also during aglycemic episodes, helping to maintain synaptic function. These data reveal a molecular pathway in astrocytes that is responsible for brain metabolic coupling to neurons.



Gene Ontology Annotations    

Biological Process

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Adcy10  (adenylate cyclase 10)


Additional Information