RGD Reference Report - Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals.

Authors: Buck, J  Sinclair, ML  Schapal, L  Cann, MJ  Levin, LR 
Citation: Buck J, etal., Proc Natl Acad Sci U S A 1999 Jan 5;96(1):79-84.
RGD ID: 1299450
Pubmed: (View Article at PubMed) PMID:9874775

Mammals have nine differentially regulated isoforms of G protein-responsive transmembrane-spanning adenylyl cyclases. We now describe the existence of a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or Forskolin regulation. Northern analysis indicates the gene encoding soluble adenylyl cyclase (sAC) is preferentially expressed in testis. As purified from rat testis cytosol, the active form of sAC appears to be a fragment derived from the full-length protein, suggesting a proteolytic mechanism for sAC activation. The two presumptive catalytic domains of sAC are closely related to cyanobacterial adenylyl cyclases, providing an evolutionary link between bacterial and mammalian signaling molecules.

Annotation

Gene Ontology Annotations    

Biological Process

Cellular Component
cytosol  (IDA)

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Adcy10  (adenylate cyclase 10)


Additional Information