Fkbp5 (FKBP prolyl isomerase 5) - Rat Genome Database

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Gene: Fkbp5 (FKBP prolyl isomerase 5) Rattus norvegicus
Analyze
Symbol: Fkbp5
Name: FKBP prolyl isomerase 5
RGD ID: 1309155
Description: Predicted to enable heat shock protein binding activity; peptidyl-prolyl cis-trans isomerase activity; and protein-macromolecule adaptor activity. Involved in response to alcohol and response to cocaine. Predicted to be located in cytosol and nucleoplasm. Biomarker of alcohol dependence and cocaine abuse. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5); PARTICIPATES IN aldosterone signaling pathway; cortisol signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FK506 binding protein 5; LOC361810; peptidyl-prolyl cis-trans isomerase FKBP5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,458,931 - 6,577,227 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl206,458,940 - 6,543,118 (-)EnsemblGRCr8
mRatBN7.2206,457,207 - 6,575,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,457,216 - 6,541,674 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx207,169,862 - 7,254,715 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,531,701 - 6,616,554 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,011,129 - 7,095,687 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,976,704 - 8,097,290 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,976,713 - 8,019,020 (-)Ensemblrn6Rnor6.0
Rnor_5.02010,177,058 - 10,296,330 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4206,637,478 - 6,686,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera208,013,420 - 8,098,415 (-)NCBICelera
RGSC_v3.1206,637,712 - 6,722,980 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenoxybenzoic acid  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alcohol  (EXP,ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atenolol  (ISO)
Aurin  (ISO)
azoxystrobin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
CCCP  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroethene  (ISO)
chloroprene  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
ciclopirox  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dapsone  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ferrostatin-1  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
Galiellalactone  (ISO)
genistein  (EXP)
glafenine  (EXP)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP,ISO)
graphene oxide  (ISO)
hexadecanoic acid  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
lead diacetate  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
maneb  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nefazodone  (ISO)
nevirapine  (EXP)
niclosamide  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quinomethionate  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thiram  (ISO)
tibolone  (ISO)
tioguanine  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Chronic cocaine administration upregulates FKBP5 in the extended amygdala of male and female rats. Connelly KL and Unterwald EM, Drug Alcohol Depend. 2019 Jun 1;199:101-105. doi: 10.1016/j.drugalcdep.2019.02.019. Epub 2019 Apr 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice. Huang MC, etal., Neuropsychopharmacology. 2014 Jul;39(8):2029-38. doi: 10.1038/npp.2014.55. Epub 2014 Mar 7.
5. Stress-Responsive Gene FK506-Binding Protein 51 Mediates Alcohol-Induced Liver Injury Through the Hippo Pathway and Chemokine (C-X-C Motif) Ligand 1 Signaling. Kusumanchi P, etal., Hepatology. 2021 Sep;74(3):1234-1250. doi: 10.1002/hep.31800. Epub 2021 Aug 30.
6. Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. Levran O, etal., Psychoneuroendocrinology. 2014 Jul;45:67-76. doi: 10.1016/j.psyneuen.2014.03.017. Epub 2014 Apr 6.
7. Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans. Nylander I, etal., Mol Neurobiol. 2017 Oct;54(8):6225-6234. doi: 10.1007/s12035-016-0157-z. Epub 2016 Oct 5.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
10. The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans. Qiu B, etal., Int J Mol Sci. 2016 Aug 5;17(8):1271. doi: 10.3390/ijms17081271.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Roy A, etal., Neuropsychopharmacology. 2010 Jul;35(8):1674-83. doi: 10.1038/npp.2009.236. Epub 2010 Jan 20.
15. FKBP5 rs4713916: A Potential Genetic Predictor of Interindividual Different Response to Inhaled Corticosteroids in Patients with Chronic Obstructive Pulmonary Disease in a Real-Life Setting. Russo P, etal., Int J Mol Sci. 2019 Apr 24;20(8):2024. doi: 10.3390/ijms20082024.
16. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:9660753   PMID:11350175   PMID:12477932   PMID:19056867   PMID:19946888   PMID:22318949   PMID:23012479   PMID:23169346   PMID:24139875   PMID:26482332   PMID:27655894   PMID:28298552  
PMID:28826069   PMID:29738768   PMID:30101500   PMID:35296422   PMID:36116554   PMID:38540789   PMID:38557197  


Genomics

Comparative Map Data
Fkbp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,458,931 - 6,577,227 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl206,458,940 - 6,543,118 (-)EnsemblGRCr8
mRatBN7.2206,457,207 - 6,575,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,457,216 - 6,541,674 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx207,169,862 - 7,254,715 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,531,701 - 6,616,554 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,011,129 - 7,095,687 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,976,704 - 8,097,290 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,976,713 - 8,019,020 (-)Ensemblrn6Rnor6.0
Rnor_5.02010,177,058 - 10,296,330 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4206,637,478 - 6,686,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera208,013,420 - 8,098,415 (-)NCBICelera
RGSC_v3.1206,637,712 - 6,722,980 (-)NCBI
Cytogenetic Map20p12NCBI
FKBP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38635,573,590 - 35,728,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl635,572,945 - 35,728,622 (-)Ensemblhg38GRCh38
GRCh37635,541,367 - 35,696,360 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36635,649,345 - 35,764,692 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34635,649,345 - 35,764,692NCBI
Celera637,095,325 - 37,250,941 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,262,003 - 35,414,145 (-)NCBIHuRef
CHM1_1635,543,370 - 35,695,008 (-)NCBICHM1_1
T2T-CHM13v2.0635,396,664 - 35,548,947 (-)NCBIT2T-CHM13v2.0
Fkbp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,617,727 - 28,705,123 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,618,068 - 28,736,501 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381728,398,753 - 28,486,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,399,094 - 28,517,527 (-)Ensemblmm10GRCm38
MGSCv371728,536,040 - 28,578,001 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361728,126,686 - 28,213,677 (-)NCBIMGSCv36mm8
Celera1728,952,443 - 28,994,535 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.66NCBI
Fkbp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,447,075 - 3,548,564 (-)Ensembl
ChiLan1.0NW_0049554373,445,515 - 3,548,874 (-)NCBIChiLan1.0ChiLan1.0
FKBP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2550,041,656 - 50,157,135 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1645,909,174 - 46,025,026 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,135,745 - 35,250,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,337,883 - 36,452,664 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,337,883 - 36,452,664 (-)EnsemblpanPan2panpan1.1
FKBP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,724,668 - 4,833,691 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl124,727,497 - 4,833,323 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha124,740,948 - 4,848,966 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0125,063,927 - 5,168,920 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1124,723,945 - 4,831,451 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,803,014 - 4,910,568 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,902,109 - 5,010,966 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fkbp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,257,337 - 40,350,757 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,640,355 - 23,700,314 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,611,166 - 23,702,283 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKBP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,440,842 - 31,567,487 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1731,441,764 - 31,550,704 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,370,570 - 36,478,505 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FKBP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,432,595 - 36,551,233 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,481,024 - 36,552,456 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604435,490,229 - 35,609,781 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fkbp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,870,240 - 21,929,838 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475421,825,122 - 21,930,870 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fkbp5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1185,418,543 - 5,460,703 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fkbp5
448 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:527
Count of miRNA genes:263
Interacting mature miRNAs:315
Transcripts:ENSRNOT00000033119
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
D20Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,514,977 - 6,515,143 (+)MAPPERmRatBN7.2
Rnor_6.0208,034,467 - 8,034,632NCBIRnor6.0
Rnor_5.02010,234,757 - 10,234,922UniSTSRnor5.0
RGSC_v3.4206,695,531 - 6,695,696UniSTSRGSC3.4
Celera208,071,384 - 8,071,549UniSTS
Cytogenetic Map20p12UniSTS
D20Got119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,462,036 - 6,462,274 (+)MAPPERmRatBN7.2
Rnor_6.0207,981,532 - 7,981,769NCBIRnor6.0
Rnor_5.02010,181,883 - 10,182,120UniSTSRnor5.0
RGSC_v3.4206,642,306 - 6,642,543UniSTSRGSC3.4
Celera208,018,222 - 8,018,463UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033119   ⟹   ENSRNOP00000034024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,458,940 - 6,517,643 (-)Ensembl
mRatBN7.2 Ensembl206,457,216 - 6,516,128 (-)Ensembl
Rnor_6.0 Ensembl207,976,713 - 8,019,020 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109678   ⟹   ENSRNOP00000084395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,458,940 - 6,543,118 (-)Ensembl
mRatBN7.2 Ensembl206,457,216 - 6,541,674 (-)Ensembl
RefSeq Acc Id: NM_001012174   ⟹   NP_001012174
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,458,931 - 6,543,555 (-)NCBI
mRatBN7.2206,457,207 - 6,541,835 (-)NCBI
Rnor_6.0207,976,704 - 8,061,724 (-)NCBI
Rnor_5.02010,177,058 - 10,296,330 (-)NCBI
RGSC_v3.4206,637,478 - 6,686,768 (-)RGD
Celera208,013,420 - 8,098,415 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256222   ⟹   XP_006256284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,458,931 - 6,517,675 (-)NCBI
mRatBN7.2206,457,207 - 6,516,504 (-)NCBI
Rnor_6.0207,976,704 - 8,036,022 (-)NCBI
Rnor_5.02010,177,058 - 10,296,330 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256224   ⟹   XP_006256286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,458,931 - 6,577,227 (-)NCBI
mRatBN7.2206,457,207 - 6,575,404 (-)NCBI
Rnor_6.0207,976,704 - 8,097,290 (-)NCBI
Rnor_5.02010,177,058 - 10,296,330 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098819   ⟹   XP_038954747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,458,931 - 6,543,417 (-)NCBI
mRatBN7.2206,457,207 - 6,541,694 (-)NCBI
RefSeq Acc Id: NP_001012174   ⟸   NM_001012174
- UniProtKB: Q5U2T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256286   ⟸   XM_006256224
- Peptide Label: isoform X3
- UniProtKB: Q5U2T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256284   ⟸   XM_006256222
- Peptide Label: isoform X1
- UniProtKB: F7EYK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034024   ⟸   ENSRNOT00000033119
RefSeq Acc Id: XP_038954747   ⟸   XM_039098819
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZX46 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084395   ⟸   ENSRNOT00000109678
Protein Domains
PPIase FKBP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2T9-F1-model_v2 AlphaFold Q5U2T9 1-456 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309155 AgrOrtholog
BioCyc Gene G2FUF-4420 BioCyc
Ensembl Genes ENSRNOG00000022523 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033119 ENTREZGENE
  ENSRNOT00000033119.7 UniProtKB/TrEMBL
  ENSRNOT00000109678 ENTREZGENE
  ENSRNOT00000109678.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  3.10.50.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191081 IMAGE-MGC_LOAD
InterPro Immunophilin_FKBP-type UniProtKB/TrEMBL
  PPIase_dom_sf UniProtKB/TrEMBL
  PPIase_FKBP UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
KEGG Report rno:361810 UniProtKB/TrEMBL
MGC_CLONE MGC:94621 IMAGE-MGC_LOAD
NCBI Gene 361810 ENTREZGENE
PANTHER PEPTIDYLPROLYL ISOMERASE UniProtKB/TrEMBL
  TETRATRICOPEPTIDE REPEAT DOMAIN 9 UniProtKB/TrEMBL
Pfam FKBP_C UniProtKB/TrEMBL
  TPR_1 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PharmGKB FKBP5 RGD
PhenoGen Fkbp5 PhenoGen
PROSITE FKBP_PPIASE UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022523 RatGTEx
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP FKBP-like UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt A0A8I5ZX46 ENTREZGENE, UniProtKB/TrEMBL
  F7EYK0 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2T9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-09 Fkbp5  FKBP prolyl isomerase 5  Fkbp5  FK506 binding protein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Fkbp5  FK506 binding protein 5  Fkbp5_predicted  FK506 binding protein 5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fkbp5_predicted  FK506 binding protein 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED