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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309155
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fkbp5
Name: FKBP prolyl isomerase 5
Acc ID: CHEBI:4325
Term: dapsone
Definition: A sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
Chemical ID: MESH:D003622
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fkbp5multiple interactionsISOFKBP5 (Homo sapiens)6480464CTDDapsone analog inhibits the reaction [Metribolone results in increased expression of FKBP5 mRNA]PMID:21440447
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