Ddit4 (DNA-damage-inducible transcript 4) - Rat Genome Database

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Gene: Ddit4 (DNA-damage-inducible transcript 4) Rattus norvegicus
Analyze
Symbol: Ddit4
Name: DNA-damage-inducible transcript 4
RGD ID: 621731
Description: Predicted to enable 14-3-3 protein binding activity. Involved in several processes, including negative regulation of TOR signaling; nervous system development; and neurotrophin TRK receptor signaling pathway. Predicted to be located in cytosol and mitochondrion. Orthologous to human DDIT4 (DNA damage inducible transcript 4); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2,4-trimethylbenzene; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801; protein regulated in development and DNA damage response 1; REDD-1; Rtp801
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82028,434,938 - 28,437,037 (-)NCBIGRCr8
mRatBN7.22027,891,989 - 27,894,088 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,891,998 - 27,894,105 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2028,903,584 - 28,905,683 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02028,289,842 - 28,291,941 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,032,605 - 29,034,704 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,509,283 - 29,511,382 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,509,289 - 29,511,382 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02031,315,024 - 31,317,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42027,252,273 - 27,254,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12027,266,073 - 27,268,171 (-)NCBI
Celera2029,333,162 - 29,335,357 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,3-dinitrobenzene  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-aminobenzhydrazide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
adenine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
anthracen-2-amine  (EXP)
antimycin A  (ISO)
arachidonic acid  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
bafilomycin A1  (EXP)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A5  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
cefaloridine  (EXP)
celastrol  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
diisononyl phthalate  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylselenide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
Ethylenethiourea  (EXP)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gedunin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 501516  (ISO)
helenalin  (ISO)
hexaconazole  (ISO)
hexanal  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyl  (ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irinotecan  (EXP)
iron dichloride  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
kenpaullone  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
mancozeb  (EXP)
maneb  (EXP)
menadione  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mithramycin  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
Muraglitazar  (EXP)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-succinylsulfathiazole  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
nevirapine  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
orlistat  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
picene  (ISO)
pinostrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
prothioconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (EXP)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP,ISO)
triacsin C  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vanillin  (ISO)
vinclozolin  (EXP)
withaferin A  (ISO)
Yessotoxin  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO,ISS)
cytosol  (IEA,ISO)
mitochondrion  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Hypoxia-inducible factor-1alpha accumulation in the brain after experimental intracerebral hemorrhage. Jiang Y, etal., J Cereb Blood Flow Metab 2002 Jun;22(6):689-96.
3. RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. Malagelada C, etal., J Neurosci. 2008 Dec 31;28(53):14363-71. doi: 10.1523/JNEUROSCI.3928-08.2008.
4. RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration. Malagelada C, etal., J Neurosci. 2011 Mar 2;31(9):3186-96. doi: 10.1523/JNEUROSCI.4011-10.2011.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Shoshani T, etal., Mol Cell Biol 2002 Apr;22(7):2283-93.
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12453409   PMID:17005863   PMID:17074751   PMID:17556672   PMID:18198340   PMID:18336631   PMID:18850054   PMID:19127203   PMID:19297425   PMID:20032058   PMID:20166753   PMID:20176937  
PMID:21192293   PMID:21272563   PMID:21410687   PMID:21478870   PMID:21896779   PMID:23978538   PMID:24018049   PMID:24458146   PMID:24691733   PMID:25101677   PMID:25450383   PMID:25876513  
PMID:27105917   PMID:27233899   PMID:32732871   PMID:33745924   PMID:36375964  


Genomics

Comparative Map Data
Ddit4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82028,434,938 - 28,437,037 (-)NCBIGRCr8
mRatBN7.22027,891,989 - 27,894,088 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,891,998 - 27,894,105 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2028,903,584 - 28,905,683 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02028,289,842 - 28,291,941 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,032,605 - 29,034,704 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,509,283 - 29,511,382 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,509,289 - 29,511,382 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02031,315,024 - 31,317,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42027,252,273 - 27,254,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12027,266,073 - 27,268,171 (-)NCBI
Celera2029,333,162 - 29,335,357 (-)NCBICelera
Cytogenetic Map20q11NCBI
DDIT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,273,924 - 72,276,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,273,919 - 72,276,036 (+)EnsemblGRCh38hg38GRCh38
GRCh371074,033,682 - 74,035,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,703,683 - 73,705,803 (+)NCBINCBI36Build 36hg18NCBI36
Build 341073,703,682 - 73,705,803NCBI
Celera1067,317,429 - 67,319,550 (+)NCBICelera
Cytogenetic Map10q22.1ENTREZGENE
HuRef1068,028,151 - 68,030,271 (+)NCBIHuRef
CHM1_11074,315,457 - 74,317,577 (+)NCBICHM1_1
T2T-CHM13v2.01073,144,950 - 73,147,062 (+)NCBIT2T-CHM13v2.0
Ddit4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,785,497 - 59,787,592 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,785,491 - 59,787,656 (-)EnsemblGRCm39 Ensembl
GRCm381059,949,675 - 59,951,770 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,949,669 - 59,951,834 (-)EnsemblGRCm38mm10GRCm38
MGSCv371059,412,423 - 59,414,518 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361059,345,032 - 59,347,127 (-)NCBIMGSCv36mm8
Celera1061,046,891 - 61,048,986 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.66NCBI
Ddit4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543719,322,407 - 19,324,562 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543719,322,407 - 19,324,562 (-)NCBIChiLan1.0ChiLan1.0
DDIT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2884,423,173 - 84,426,596 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11084,429,789 - 84,431,917 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01068,796,712 - 68,798,840 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11071,264,028 - 71,266,155 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,264,029 - 71,266,149 (+)Ensemblpanpan1.1panPan2
DDIT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,916,718 - 22,918,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,916,096 - 22,964,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,053,206 - 23,055,382 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,196,970 - 23,199,141 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,196,350 - 23,199,152 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,097,917 - 23,100,093 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,298,834 - 23,301,011 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0423,652,232 - 23,654,408 (+)NCBIUU_Cfam_GSD_1.0
Ddit4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721358,154,142 - 58,156,276 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,646,797 - 6,648,983 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,646,864 - 6,648,982 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDIT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,117,710 - 75,119,902 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,117,708 - 75,119,907 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DDIT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,033,058 - 59,035,157 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl959,032,755 - 59,035,241 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604819,668,791 - 19,670,901 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddit4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247546,091,809 - 6,094,525 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247546,091,914 - 6,094,035 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ddit4
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:416
Count of miRNA genes:236
Interacting mature miRNAs:295
Transcripts:ENSRNOT00000000703
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
RH132188  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22027,892,211 - 27,892,418 (+)MAPPERmRatBN7.2
Rnor_6.02029,509,506 - 29,509,712NCBIRnor6.0
Rnor_5.02031,315,247 - 31,315,453UniSTSRnor5.0
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000085026   ⟹   ENSRNOP00000073198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,891,998 - 27,894,105 (-)Ensembl
Rnor_6.0 Ensembl2029,509,289 - 29,511,382 (-)Ensembl
RefSeq Acc Id: NM_080906   ⟹   NP_543182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,434,938 - 28,437,037 (-)NCBI
mRatBN7.22027,891,989 - 27,894,088 (-)NCBI
Rnor_6.02029,509,283 - 29,511,382 (-)NCBI
Rnor_5.02031,315,024 - 31,317,123 (-)NCBI
RGSC_v3.42027,252,273 - 27,254,371 (-)RGD
Celera2029,333,162 - 29,335,357 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_543182 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62021 (Get FASTA)   NCBI Sequence Viewer  
  AAL38423 (Get FASTA)   NCBI Sequence Viewer  
  EDL93064 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073198.1
  ENSRNOP00055012214
  ENSRNOP00060003921
GenBank Protein Q8VHZ9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_543182   ⟸   NM_080906
- UniProtKB: Q8VHZ9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073198   ⟸   ENSRNOT00000085026

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHZ9-F1-model_v2 AlphaFold Q8VHZ9 1-229 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701594
Promoter ID:EPDNEW_R12117
Type:single initiation site
Name:Ddit4_1
Description:DNA-damage-inducible transcript 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02029,511,396 - 29,511,456EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621731 AgrOrtholog
BioCyc Gene G2FUF-3751 BioCyc
Ensembl Genes ENSRNOG00000057078 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055009023 UniProtKB/Swiss-Prot
  ENSRNOG00060003243 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085026.2 UniProtKB/TrEMBL
  ENSRNOT00055015255 UniProtKB/Swiss-Prot
  ENSRNOT00060005324 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.470.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623446 IMAGE-MGC_LOAD
InterPro RTP801-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTP801-like_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140942 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72327 IMAGE-MGC_LOAD
NCBI Gene 140942 ENTREZGENE
PANTHER DNA DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12478 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RTP801_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ddit4 PhenoGen
RatGTEx ENSRNOG00000057078 RatGTEx
  ENSRNOG00055009023 RatGTEx
  ENSRNOG00060003243 RatGTEx
UniProt A6K3V8_RAT UniProtKB/TrEMBL
  DDIT4_RAT UniProtKB/Swiss-Prot
  G3V620_RAT UniProtKB/TrEMBL
  Q8VHZ9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ddit4  DNA-damage-inducible transcript 4  Rtp801  HIF-1 responsive RTP801  Symbol and Name updated 1299863 APPROVED
2002-08-07 Rtp801  HIF-1 responsive RTP801      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is up regulation by hypoxia 633979