Ddit4 (DNA damage inducible transcript 4)

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Gene: Ddit4 (DNA damage inducible transcript 4) Chinchilla lanigera

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Symbol:

Ddit4

Name:

DNA damage inducible transcript 4

RGD ID:

9056006

Description:

ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); INVOLVED IN brain development (ortholog); cellular response to dexamethasone stimulus (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); leukemia (ortholog); mouth disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA-damage-inducible transcript 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	19,322,407 - 19,324,562 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	19,322,407 - 19,324,562 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

leukemia (ISO)

mouth disease (ISO)

Nerve Degeneration (ISO)

Parkinson's disease (ISO)

rheumatoid arthritis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (ISO)

cellular response to dexamethasone stimulus (ISO)

intracellular signal transduction (ISO)

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ISO)

negative regulation of glycolytic process (ISO)

negative regulation of TOR signaling (ISO)

neuron differentiation (ISO)

neuron migration (ISO)

neurotrophin TRK receptor signaling pathway (ISO)

protein-containing complex disassembly (ISO)

reactive oxygen species metabolic process (ISO)

response to hypoxia (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

mitochondrion (ISO)

Molecular Function

14-3-3 protein binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ddit4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	19,322,407 - 19,324,562 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	19,322,407 - 19,324,562 (-)	NCBI	ChiLan1.0	ChiLan1.0

DDIT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	72,273,924 - 72,276,036 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	72,273,919 - 72,276,036 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	74,033,682 - 74,035,794 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	73,703,683 - 73,705,803 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	73,703,682 - 73,705,803	NCBI
Celera	10	67,317,429 - 67,319,550 (+)	NCBI		Celera
Cytogenetic Map	10	q22.1	ENTREZGENE
HuRef	10	68,028,151 - 68,030,271 (+)	NCBI		HuRef
CHM1_1	10	74,315,457 - 74,317,577 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	73,144,950 - 73,147,062 (+)	NCBI		T2T-CHM13v2.0

Ddit4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	59,785,497 - 59,787,592 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	59,785,491 - 59,787,656 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	59,949,675 - 59,951,770 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	59,949,669 - 59,951,834 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	59,412,423 - 59,414,518 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	59,345,032 - 59,347,127 (-)	NCBI		MGSCv36	mm8
Celera	10	61,046,891 - 61,048,986 (-)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	29.66	NCBI

Ddit4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	28,434,938 - 28,437,037 (-)	NCBI		GRCr8
mRatBN7.2	20	27,891,989 - 27,894,088 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	27,891,998 - 27,894,105 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	28,903,584 - 28,905,683 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	28,289,842 - 28,291,941 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	29,032,605 - 29,034,704 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	29,509,283 - 29,511,382 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	29,509,289 - 29,511,382 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	31,315,024 - 31,317,123 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	27,252,273 - 27,254,371 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	27,266,073 - 27,268,171 (-)	NCBI
Celera	20	29,333,162 - 29,335,357 (-)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

DDIT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	84,423,173 - 84,426,596 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	84,429,789 - 84,431,917 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	68,796,712 - 68,798,840 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	71,264,028 - 71,266,155 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	71,264,029 - 71,266,149 (+)	Ensembl	panpan1.1		panPan2

DDIT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	22,916,718 - 22,918,893 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	22,916,096 - 22,964,035 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	23,053,206 - 23,055,382 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	23,196,970 - 23,199,141 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	23,196,350 - 23,199,152 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	23,097,917 - 23,100,093 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	23,298,834 - 23,301,011 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	23,652,232 - 23,654,408 (+)	NCBI		UU_Cfam_GSD_1.0

Ddit4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	58,154,142 - 58,156,276 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936521	6,646,797 - 6,648,983 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936521	6,646,864 - 6,648,982 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DDIT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	75,117,710 - 75,119,902 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	75,117,708 - 75,119,907 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DDIT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	59,033,058 - 59,035,157 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	59,032,755 - 59,035,241 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	19,668,791 - 19,670,901 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ddit4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	6,091,809 - 6,094,525 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	6,091,914 - 6,094,035 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005390015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01034844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01073108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000024665 ⟹ ENSCLAP00000024430

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955437	19,322,407 - 19,324,562 (-)	Ensembl

RefSeq Acc Id:

XM_005390015 ⟹ XP_005390072

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955437	19,322,407 - 19,324,562 (-)	NCBI

Sequence:

show sequence

GATCGCAGCAGGCCAAGGGGGAGGTGCGGGAGGCTAAAAGGGACAGGTCTGGGCAGCGCTCGGT
GGTTGGCACCAGTTCGCGCACCCATTCAAGCGGCCGGACTCACCTGTCCCAGCAGTTCTCGCTG
ACCGTGCGAGTTGCGGCTTCTTCGCTCCGGCACCCTTGAGCTCATCAACGAACTCCTGGCTTCC
GACTTCACCATGCCTAACCTTTGGGACCGCTTCTCCTCCGCCTCCTCTTCGTCTTCGTCGCGAA
CGCCCACCCCGGATCGGCCTCCGCGCTCGGCCTGGGGGTCGGCGGCCCGGGAGGAGGGGCTGGA
CCGCTGCGCGAGCCTCGAGAGCTCGGACTGCGAGTCCCTGGACAGCAGCAACAGCGGCTTCGGG
CCGGAGGAAGATTCGGCCTACTTGGATGGGGTGTCCCTGCCCGACTTCGAGCTGCTCAGTGACC
CCGAGGATGAGCACCTGTGTGCCAGCCTCATGCAGCTGCTCCAGGAGAGCCTGTCCCAGGCGCG
ACTGGGCTCACGCCGTCCCGCGCGCCTGCTGATGCCAGCCCAGCTGGTGAGCCAGGTGGGCAAA
GAACTGCTGCGCCTGGCGTACAGCGAGCCGTGCGGCCTGCGGGGGGCGCTGCTCGACGTCTGCG
TGGAGCAGGGCAAGAGCTGCCACAGCGTGGGCCAGCTGGCCCTCGACCCTAGCCTGGTGCCCAC
CTTCCAGCTGACCTTGGTGCTGCGCCTGGACTCTCGCCTGTGGCCCAAGATCCAGGGGCTGTTC
AGTTCGGCCAACTCTCCTTTCGTCCCCGGCTTCAGTCAGTCCCTAACACTGGGCACCGGCTTCA
GAGTCATCAAGAAGAAGCTGTACAGCTCCGAGCAGCTGCTCATCGAGGAGTGCTGAGCTCCCGC
CCGGGGGCTGCACTGCCCCCACGGCAGACAGTAAACTTTTAGGGTGGAGACTTGGCAGGCCAGG
GCCAAGGCACTGATGCCTGTGTTAGAAAACTGACAATAGCCCCCAGTGGAGGAGGTTGCAGAGG
GGGGAGCGTAGTGTTTCCTAGGAAGCTCACTGAGTTGTGTGCAGGTGGGTCCCCGTCGGGGCGC
ATGCCCCTCAGTACTGTAGCATGAAACAAAGGCTTAGGGGCCTTCAGGCTTCCGGCTGGATGTG
TATGTAGCATGTACCGTATTATTTTTATTATCCCTGACAGTACCACGGCAGTGGTGTGACAGCT
AGGAGGGCAGCTGGGCTGTGCTGGCCTCGGCCAGGGGTGTGTGCTTCTGGTAGCTGCCAGGAGG
GAGGGGGGGAGGACTTGGAGTTGGTTTGTGTAGCCCAGTCTGGAGGGACCAAGTGTGTTTGTTG
TTTATTTTGTATCTTGTTTTTCGGATCGGAGCTTCACTACTGACCTGTTCTAGGCAGCTATCTT
ACAGACGCATGAATGTAAGAGTGAAAGGGGTGGGTGTTAGGGTCCCTTGGGACCTTTGACACTG
GAAGACAAAATACACCTGAGAGCTGCGTCCAAACCCGTCCCCCACCGCGACCCAGAGAACTGAA
CTGTGAGGGGTGGGGCTGAGTGGGGATGGGGCTGGAACCCCCTCCCCAGAGGAGTGCCATCCGG
GTCTTCCATTTAGAACTGTTGTTTACATGAAGATACTCACTGTTCATAAATACACTTGATGTTC
AAGTATTAAGACCTATGCAATATTTTTTACTTTTCTAATAAACATGTTTGTTAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005390072	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000024430
	ENSCLAP00000024430.1

RefSeq Acc Id:

XP_005390072 ⟸ XM_005390015

- UniProtKB:

A0A8C2WB42 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPNLWDRFSSASSSSSSRTPTPDRPPRSAWGSAAREEGLDRCASLESSDCESLDSSNSGFGPEE
DSAYLDGVSLPDFELLSDPEDEHLCASLMQLLQESLSQARLGSRRPARLLMPAQLVSQVGKELL
RLAYSEPCGLRGALLDVCVEQGKSCHSVGQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLFSSA
NSPFVPGFSQSLTLGTGFRVIKKKLYSSEQLLIEEC

hide sequence

Ensembl Acc Id:

ENSCLAP00000024430 ⟸ ENSCLAT00000024665

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000016774	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000024665	ENTREZGENE
	ENSCLAT00000024665.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.470.40	UniProtKB/TrEMBL
InterPro	RTP801-like	UniProtKB/TrEMBL
	RTP801-like_C_sf	UniProtKB/TrEMBL
NCBI Gene	Ddit4	ENTREZGENE
PANTHER	DNA DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN	UniProtKB/TrEMBL
	PTHR12478	UniProtKB/TrEMBL
Pfam	RTP801_C	UniProtKB/TrEMBL
UniProt	A0A8C2WB42	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Ddit4	DNA damage inducible transcript 4		DNA-damage-inducible transcript 4	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)