Stk39 (serine threonine kinase 39) - Rat Genome Database

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Gene: Stk39 (serine threonine kinase 39) Rattus norvegicus
Analyze
Symbol: Stk39
Name: serine threonine kinase 39
RGD ID: 621643
Description: Enables several functions, including protein kinase binding activity; transmembrane transporter binding activity; and transporter activator activity. Involved in positive regulation of cation transmembrane transport; positive regulation of p38MAPK cascade; and protein autophosphorylation. Located in cell cortex and cytosol. Orthologous to human STK39 (serine/threonine kinase 39); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: pancreatic serine/threonine-protein kinase; PS/TK; PSTK1; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine/threonine kinase 39, STE20/SPS1 homolog; serine/threonine kinase 39, STE20/SPS1 homolog (yeast); serine/threonine-protein kinase 39; Spak; Ste-20 related kinase; ste-20-related kinase; STE20/SPS1-related proline-alanine-rich protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Stk39em2Mcwi ; Stk39em5Mcwi ; Stk39em6Mcwi
Genetic Models: SS-Stk39em2Mcwi-/- ; SS-Stk39em2Mcwi ; SS-Stk39em2Mcwi-/+ ; SS-Stk39em5Mcwi ; SS-Stk39em6Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8373,321,522 - 73,588,397 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl373,321,522 - 73,586,740 (-)EnsemblGRCr8
mRatBN7.2352,913,583 - 53,179,060 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl352,913,585 - 53,179,060 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx356,307,442 - 56,572,955 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0364,891,008 - 65,156,536 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0362,649,675 - 62,915,802 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0354,359,449 - 54,625,702 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl354,359,451 - 54,625,414 (-)Ensemblrn6Rnor6.0
Rnor_5.0360,973,443 - 61,244,306 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4350,249,626 - 50,517,085 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera352,482,845 - 52,746,814 (-)NCBICelera
RGSC_v3.1350,297,966 - 50,413,457 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dactolisib  (ISO)
daidzein  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
eplerenone  (ISO)
equol  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
methapyrilene  (ISO)
methoxyacetic acid  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosomorpholine  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
Rebamipide  (EXP)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell volume homeostasis  (IEA,ISO)
cellular hyperosmotic response  (IBA,IEA,ISO)
cellular hypotonic response  (IEA,ISO)
cellular response to chemokine  (IEA,ISO)
cellular response to potassium ion  (IEA,ISO)
chemokine (C-X-C motif) ligand 12 signaling pathway  (IEA,ISO)
inflammatory response  (IEA,ISO)
intracellular chloride ion homeostasis  (IEA,ISO)
intracellular signal transduction  (IBA,IEA,ISO)
macrophage activation  (IEA,ISO)
maintenance of lens transparency  (IEA,ISO)
monoatomic ion homeostasis  (ISO)
negative regulation of pancreatic juice secretion  (IEA,ISO)
negative regulation of potassium ion transmembrane transport  (IEA,ISO)
negative regulation of sodium ion transmembrane transport  (IEA,ISO)
negative regulation of transmembrane transport  (IEA,ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of p38MAPK cascade  (IEA,IMP,ISO)
positive regulation of potassium ion import across plasma membrane  (IMP)
positive regulation of potassium ion transport  (IMP)
positive regulation of sodium ion import across plasma membrane  (IMP)
positive regulation of T cell chemotaxis  (IBA,IEA,ISO)
protein autophosphorylation  (IMP,ISO,ISS)
protein phosphorylation  (IDA,ISO)
regulation of blood pressure  (ISO)
regulation of inflammatory response  (ISO)
regulation of monoatomic cation transmembrane transport  (IEA,ISO)
renal sodium ion absorption  (IEA,ISO)
response to aldosterone  (IEA,ISO)
response to dietary excess  (IEA,ISO)
signal transduction  (IEA,ISO)
sodium ion transmembrane transport  (IEA,ISO)

Cellular Component
apical plasma membrane  (IEA,ISO)
basolateral plasma membrane  (IEA,ISO)
cell body  (IEA,ISO)
cell cortex  (IDA)
cytoplasm  (IBA,IEA)
cytosol  (IBA,IDA,IEA,IMP,ISO)
membrane  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). Dowd BF and Forbush B, J Biol Chem. 2003 Jul 25;278(30):27347-53. Epub 2003 May 9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons. Geng Y, etal., J Biol Chem. 2009 May 22;284(21):14020-8. Epub 2009 Mar 23.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway. Inoue K, etal., J Biol Chem. 2012 Jun 15;287(25):20839-50. doi: 10.1074/jbc.M111.319418. Epub 2012 Apr 27.
6. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Johnston AM, etal., Oncogene 2000 Aug 31;19(37):4290-7.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Molecular cloning and characterization of a novel Ste20-related protein kinase enriched in neurons and transporting epithelia. Ushiro H, etal., Arch Biochem Biophys 1998 Jul 15;355(2):233-40.
13. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Vitari AC, etal., Biochem J. 2005 Oct 1;391(Pt 1):17-24.
14. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses. Vorontsova I, etal., Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):310-21. doi: 10.1167/iovs.14-15911.
Additional References at PubMed
PMID:12386165   PMID:16530727   PMID:16669787   PMID:21317537   PMID:21705622   PMID:21907141   PMID:22238094   PMID:24133122   PMID:24393035   PMID:24811174   PMID:25531585   PMID:27400149  
PMID:27782176   PMID:28755400   PMID:30053369   PMID:34396440   PMID:35163352  


Genomics

Comparative Map Data
Stk39
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8373,321,522 - 73,588,397 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl373,321,522 - 73,586,740 (-)EnsemblGRCr8
mRatBN7.2352,913,583 - 53,179,060 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl352,913,585 - 53,179,060 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx356,307,442 - 56,572,955 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0364,891,008 - 65,156,536 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0362,649,675 - 62,915,802 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0354,359,449 - 54,625,702 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl354,359,451 - 54,625,414 (-)Ensemblrn6Rnor6.0
Rnor_5.0360,973,443 - 61,244,306 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4350,249,626 - 50,517,085 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera352,482,845 - 52,746,814 (-)NCBICelera
RGSC_v3.1350,297,966 - 50,413,457 (-)NCBI
Cytogenetic Map3q21NCBI
STK39
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382167,954,022 - 168,247,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2167,949,900 - 168,247,739 (-)Ensemblhg38GRCh38
GRCh372168,810,532 - 169,104,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362168,518,776 - 168,812,351 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342168,636,037 - 168,929,612NCBI
Celera2162,419,314 - 162,712,878 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2160,690,590 - 160,918,691 (-)NCBIHuRef
CHM1_12168,816,415 - 169,109,972 (-)NCBICHM1_1
T2T-CHM13v2.02168,411,922 - 168,705,066 (-)NCBIT2T-CHM13v2.0
Stk39
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39268,040,789 - 68,302,381 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl268,040,789 - 68,302,612 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38268,210,445 - 68,472,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl268,210,445 - 68,472,268 (-)Ensemblmm10GRCm38
MGSCv37268,048,504 - 68,310,038 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36268,011,286 - 68,272,820 (-)NCBIMGSCv36mm8
Celera269,878,607 - 70,140,879 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map239.53NCBI
Stk39
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554496,167,752 - 6,390,736 (+)Ensembl
ChiLan1.0NW_0049554496,112,726 - 6,387,925 (+)NCBIChiLan1.0ChiLan1.0
STK39
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21370,588,939 - 70,885,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B70,603,916 - 70,900,274 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B55,204,203 - 55,501,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B172,674,514 - 172,904,723 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B172,674,514 - 172,970,063 (-)EnsemblpanPan2panpan1.1
STK39
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13612,866,867 - 13,118,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3612,867,188 - 13,183,160 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3612,875,995 - 13,167,194 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03612,983,192 - 13,273,757 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3612,913,021 - 13,297,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,068,051 - 13,358,464 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,054,289 - 13,344,871 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03613,165,580 - 13,457,184 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stk39
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,101,476 - 130,374,107 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646911,274,409 - 11,516,752 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646911,274,398 - 11,516,244 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK39
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1574,447,787 - 74,758,122 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11574,441,019 - 74,757,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21583,412,068 - 83,666,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK39
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11053,451,035 - 53,747,847 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1053,450,891 - 53,682,993 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040145,776,885 - 146,078,123 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk39
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247875,681,928 - 5,966,699 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247875,682,023 - 5,966,770 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Stk39
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1545,569,457 - 45,829,352 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Stk39
3545 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:421
Count of miRNA genes:214
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000037133
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)35986366373704481Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
AW227544  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2352,913,777 - 52,913,926 (+)MAPPERmRatBN7.2
Rnor_6.0354,359,644 - 54,359,792NCBIRnor6.0
Rnor_5.0360,973,636 - 60,973,784UniSTSRnor5.0
RGSC_v3.4350,249,819 - 50,249,967UniSTSRGSC3.4
Celera352,483,038 - 52,483,186UniSTS
Cytogenetic Map3q21UniSTS
AI577947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2352,913,613 - 52,913,790 (+)MAPPERmRatBN7.2
Rnor_6.0354,359,480 - 54,359,656NCBIRnor6.0
Rnor_5.0360,973,472 - 60,973,648UniSTSRnor5.0
RGSC_v3.4350,249,655 - 50,249,831UniSTSRGSC3.4
Celera352,482,874 - 52,483,050UniSTS
Cytogenetic Map3q21UniSTS
RH130764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2352,914,052 - 52,914,233 (+)MAPPERmRatBN7.2
Rnor_6.0354,359,919 - 54,360,099NCBIRnor6.0
Rnor_5.0360,973,911 - 60,974,091UniSTSRnor5.0
RGSC_v3.4350,250,094 - 50,250,274UniSTSRGSC3.4
Celera352,483,313 - 52,483,493UniSTS
Cytogenetic Map3q21UniSTS
BE107798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2353,160,193 - 53,160,413 (+)MAPPERmRatBN7.2
Rnor_6.0354,606,508 - 54,606,727NCBIRnor6.0
Rnor_5.0361,222,231 - 61,222,450UniSTSRnor5.0
RGSC_v3.4350,497,811 - 50,498,030UniSTSRGSC3.4
Celera352,728,532 - 52,728,751UniSTS
Cytogenetic Map3q21UniSTS
RH138572  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2352,916,585 - 52,916,765 (+)MAPPERmRatBN7.2
Rnor_6.0354,362,452 - 54,362,631NCBIRnor6.0
Rnor_5.0360,976,444 - 60,976,623UniSTSRnor5.0
RGSC_v3.4350,252,627 - 50,252,806UniSTSRGSC3.4
Celera352,485,845 - 52,486,024UniSTS
RH 3.4 Map3607.5UniSTS
Cytogenetic Map3q21UniSTS


Genetic Models
This gene Stk39 is modified in the following models/strains:
SS-Stk39em2Mcwi-/-     SS-Stk39em2Mcwi     SS-Stk39em2Mcwi-/+     SS-Stk39em5Mcwi     SS-Stk39em6Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000037133   ⟹   ENSRNOP00000034162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl373,321,994 - 73,554,944 (-)Ensembl
mRatBN7.2 Ensembl352,913,585 - 53,120,996 (-)Ensembl
Rnor_6.0 Ensembl354,359,451 - 54,625,414 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087122   ⟹   ENSRNOP00000071256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl352,913,585 - 53,147,323 (-)Ensembl
Rnor_6.0 Ensembl354,360,420 - 54,593,306 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098784   ⟹   ENSRNOP00000089326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl373,321,522 - 73,586,740 (-)Ensembl
mRatBN7.2 Ensembl352,913,585 - 53,179,060 (-)Ensembl
RefSeq Acc Id: NM_019362   ⟹   NP_062235
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8373,321,522 - 73,586,979 (-)NCBI
mRatBN7.2352,913,585 - 53,179,060 (-)NCBI
Rnor_6.0354,359,451 - 54,625,414 (-)NCBI
Rnor_5.0360,973,443 - 61,244,306 (-)NCBI
RGSC_v3.4350,249,626 - 50,517,085 (-)RGD
Celera352,482,845 - 52,746,814 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761922   ⟹   XP_008760144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8373,321,522 - 73,554,969 (-)NCBI
mRatBN7.2352,913,583 - 53,147,292 (-)NCBI
Rnor_6.0354,359,449 - 54,593,415 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284417   ⟹   XP_063140487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8373,321,522 - 73,489,835 (-)NCBI
RefSeq Acc Id: XM_063284419   ⟹   XP_063140489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8373,321,522 - 73,455,129 (-)NCBI
RefSeq Acc Id: XM_063284420   ⟹   XP_063140490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8373,321,522 - 73,447,999 (-)NCBI
RefSeq Acc Id: XR_010064688
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8373,322,903 - 73,588,397 (-)NCBI
RefSeq Acc Id: NP_062235   ⟸   NM_019362
- UniProtKB: O70541 (UniProtKB/Swiss-Prot),   O88506 (UniProtKB/Swiss-Prot),   A0A8L2QHT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760144   ⟸   XM_008761922
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K007 (UniProtKB/TrEMBL),   A0A8L2QHT8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071256   ⟸   ENSRNOT00000087122
Ensembl Acc Id: ENSRNOP00000034162   ⟸   ENSRNOT00000037133
Ensembl Acc Id: ENSRNOP00000089326   ⟸   ENSRNOT00000098784
RefSeq Acc Id: XP_063140487   ⟸   XM_063284417
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140489   ⟸   XM_063284419
- Peptide Label: isoform X3
- UniProtKB: A6HLZ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140490   ⟸   XM_063284420
- Peptide Label: isoform X3
- UniProtKB: A6HLZ1 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase   Serine/threonine-protein kinase OSR1/WNK CCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88506-F1-model_v2 AlphaFold O88506 1-553 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621643 AgrOrtholog
BioCyc Gene G2FUF-49524 BioCyc
Ensembl Genes ENSRNOG00000024808 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037133 ENTREZGENE
  ENSRNOT00000098784 ENTREZGENE
  ENSRNOT00000098784.1 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  STE20/SPS1-PAK UniProtKB/Swiss-Prot
KEGG Report rno:54348 UniProtKB/Swiss-Prot
NCBI Gene 54348 ENTREZGENE
PANTHER STE20/SPS1-RELATED PROLINE-ALANINE-RICH PROTEIN KINASE UniProtKB/Swiss-Prot
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/Swiss-Prot
Pfam OSR1_C UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Stk39 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024808 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2K007 ENTREZGENE
  A0A8L2QHT8 ENTREZGENE, UniProtKB/TrEMBL
  A6HLZ0_RAT UniProtKB/TrEMBL
  A6HLZ1 ENTREZGENE, UniProtKB/TrEMBL
  O70541 ENTREZGENE
  O88506 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O70541 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Stk39  serine threonine kinase 39  Stk39  serine/threonine kinase 39, STE20/SPS1 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Stk39  serine/threonine kinase 39, STE20/SPS1 homolog (yeast)    serine threonine kinase 39 (STE20/SPS1 homolog, yeast)  Name updated 1299863 APPROVED
2002-08-07 Stk39  serine threonine kinase 39 (STE20/SPS1 homolog, yeast)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization found in the cytoplasm and cytoskeleton 730130
gene_domains contains a putative caspase cleavage site near the C-terminal region 727300
gene_expression mRNA expressed ubiquitously, but in higher amounts in brain and pancreas 727300
gene_pathway specifically activates the p38 pathway 727300
gene_product belongs to the SPS1 subfamily of STE20 kinases 727300