STK39 (serine/threonine kinase 39) - Rat Genome Database

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Gene: STK39 (serine/threonine kinase 39) Pan paniscus
Analyze
Symbol: STK39
Name: serine/threonine kinase 39
RGD ID: 11881041
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN monoatomic ion homeostasis (ortholog); positive regulation of ion transmembrane transporter activity (ortholog); positive regulation of potassium ion transport (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autistic disorder (ortholog); Gitelman syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); cell body (ortholog); cell cortex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: STE20/SPS1-related proline-alanine-rich protein kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21370,588,939 - 70,885,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B70,603,916 - 70,900,274 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B55,204,203 - 55,501,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B172,674,514 - 172,904,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B172,674,514 - 172,970,063 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell volume homeostasis  (IEA)
cellular hyperosmotic response  (IEA)
cellular hypotonic response  (IEA)
cellular response to chemokine  (IEA)
cellular response to potassium ion  (IEA)
chemokine (C-X-C motif) ligand 12 signaling pathway  (IEA)
chromatin remodeling  (IEA)
homeostatic process  (IEA)
inflammatory response  (IEA)
intracellular chloride ion homeostasis  (IEA)
intracellular signal transduction  (IEA)
macrophage activation  (IEA)
maintenance of lens transparency  (IEA)
monoatomic ion homeostasis  (IEA,ISO)
negative regulation of creatine transmembrane transporter activity  (IEA)
negative regulation of pancreatic juice secretion  (IEA)
negative regulation of potassium ion transmembrane transport  (IEA)
negative regulation of potassium ion transmembrane transporter activity  (IEA)
negative regulation of sodium ion transmembrane transporter activity  (IEA)
peptidyl-serine phosphorylation  (IEA)
peptidyl-threonine phosphorylation  (IEA)
phosphorylation  (IEA)
positive regulation of ion transmembrane transporter activity  (ISO)
positive regulation of p38MAPK cascade  (IEA)
positive regulation of potassium ion transport  (ISO)
positive regulation of T cell chemotaxis  (IEA)
protein autophosphorylation  (IEA)
protein phosphorylation  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of inflammatory response  (IEA,ISO)
renal sodium ion absorption  (IEA)
response to aldosterone  (IEA)
response to dietary excess  (IEA)
signal transduction  (IEA)
sodium ion transmembrane transport  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
STK39
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21370,588,939 - 70,885,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B70,603,916 - 70,900,274 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B55,204,203 - 55,501,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B172,674,514 - 172,904,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B172,674,514 - 172,970,063 (-)Ensemblpanpan1.1panPan2
STK39
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382167,954,022 - 168,247,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2167,954,020 - 168,247,595 (-)EnsemblGRCh38hg38GRCh38
GRCh372168,810,532 - 169,104,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362168,518,776 - 168,812,351 (-)NCBINCBI36Build 36hg18NCBI36
Build 342168,636,037 - 168,929,612NCBI
Celera2162,419,314 - 162,712,878 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2160,690,590 - 160,918,691 (-)NCBIHuRef
CHM1_12168,816,415 - 169,109,972 (-)NCBICHM1_1
T2T-CHM13v2.02168,411,922 - 168,705,066 (-)NCBIT2T-CHM13v2.0
Stk39
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39268,040,789 - 68,302,381 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl268,040,789 - 68,302,612 (-)EnsemblGRCm39 Ensembl
GRCm38268,210,445 - 68,472,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl268,210,445 - 68,472,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv37268,048,504 - 68,310,038 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36268,011,286 - 68,272,820 (-)NCBIMGSCv36mm8
Celera269,878,607 - 70,140,879 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
Stk39
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8373,321,522 - 73,588,397 (-)NCBIGRCr8
mRatBN7.2352,913,583 - 53,179,060 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl352,913,585 - 53,179,060 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx356,307,442 - 56,572,955 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0364,891,008 - 65,156,536 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0362,649,675 - 62,915,802 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0354,359,449 - 54,625,702 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl354,359,451 - 54,625,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0360,973,443 - 61,244,306 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,249,626 - 50,517,085 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1350,297,966 - 50,413,457 (-)NCBI
Celera352,482,845 - 52,746,814 (-)NCBICelera
Cytogenetic Map3q21NCBI
Stk39
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554496,167,752 - 6,390,736 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554496,112,726 - 6,387,925 (+)NCBIChiLan1.0ChiLan1.0
STK39
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13612,866,867 - 13,118,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3612,867,188 - 13,183,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3612,875,995 - 13,167,194 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03612,983,192 - 13,273,757 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3612,913,021 - 13,297,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,068,051 - 13,358,464 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,054,289 - 13,344,871 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03613,165,580 - 13,457,184 (-)NCBIUU_Cfam_GSD_1.0
Stk39
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,101,476 - 130,374,107 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646911,274,409 - 11,516,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646911,274,398 - 11,516,244 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK39
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1574,447,787 - 74,758,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11574,441,019 - 74,757,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21583,412,068 - 83,666,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK39
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11053,451,035 - 53,747,847 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1053,450,891 - 53,682,993 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040145,776,885 - 146,078,123 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk39
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247875,681,928 - 5,966,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247875,682,023 - 5,966,770 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSPPAT00000039571   ⟹   ENSPPAP00000016872
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B172,674,514 - 172,904,728 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000039576   ⟹   ENSPPAP00000016877
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B172,675,989 - 172,970,063 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000039577   ⟹   ENSPPAP00000016878
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B172,675,989 - 172,905,928 (-)Ensembl
RefSeq Acc Id: XM_034954433   ⟹   XP_034810324
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21370,588,939 - 70,885,297 (-)NCBI
NHGRI_mPanPan12B70,603,916 - 70,900,274 (-)NCBI
Mhudiblu_PPA_v02B55,204,385 - 55,501,033 (-)NCBI
RefSeq Acc Id: XM_055108709   ⟹   XP_054964684
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21370,588,939 - 70,885,297 (-)NCBI
NHGRI_mPanPan12B70,603,916 - 70,900,274 (-)NCBI
RefSeq Acc Id: XM_063595436   ⟹   XP_063451506
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21370,588,939 - 70,884,861 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034810324 (Get FASTA)   NCBI Sequence Viewer  
  XP_054964684 (Get FASTA)   NCBI Sequence Viewer  
  XP_063451506 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000016872.1
  ENSPPAP00000016877.1
  ENSPPAP00000016878.1
RefSeq Acc Id: XP_034810324   ⟸   XM_034954433
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AHP9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000016878   ⟸   ENSPPAT00000039577
Ensembl Acc Id: ENSPPAP00000016877   ⟸   ENSPPAT00000039576
Ensembl Acc Id: ENSPPAP00000016872   ⟸   ENSPPAT00000039571
RefSeq Acc Id: XP_054964684   ⟸   XM_055108709
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AHP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063451506   ⟸   XM_063595436
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AHP9 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031529 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000039571.1 UniProtKB/TrEMBL
  ENSPPAT00000039576.1 UniProtKB/TrEMBL
  ENSPPAT00000039577.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  STE20/SPS1-PAK UniProtKB/TrEMBL
NCBI Gene STK39 ENTREZGENE
PANTHER STE20/SPS1-RELATED PROLINE-ALANINE-RICH PROTEIN KINASE UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9AHP4_PANPA UniProtKB/TrEMBL
  A0A2R9AHP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AIL1_PANPA UniProtKB/TrEMBL