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Gene: Wnk1 (WNK lysine deficient protein kinase 1) Rattus norvegicus
Symbol: Wnk1
Name: WNK lysine deficient protein kinase 1
RGD ID: 621141
Description: Exhibits several functions, including ATP binding activity; magnesium ion binding activity; and molecular function regulator. Involved in several processes, including cellular response to calcium ion; negative regulation of sodium ion transport; and protein autophosphorylation. Localizes to cytosol and membrane. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1); PARTICIPATES IN Erk5 MAPK signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hereditary sensory neuropathy, type II; Hsn2; Prkwnk1; protein kinase lysine-deficient 1; protein kinase with no lysine 1; protein kinase, lysine deficient 1; protein kinase, lysine-deficient 1; serine/threonine-protein kinase WNK1
Homo sapiens (human) : WNK1 (WNK lysine deficient protein kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Wnk1 (WNK lysine deficient protein kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wnk1 (WNK lysine deficient protein kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : WNK1 (WNK lysine deficient protein kinase 1)
Canis lupus familiaris (dog) : WNK1 (WNK lysine deficient protein kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wnk1 (WNK lysine deficient protein kinase 1)
Sus scrofa (pig) : WNK1 (WNK lysine deficient protein kinase 1)
Chlorocebus sabaeus (African green monkey) : WNK1 (WNK lysine deficient protein kinase 1)
Heterocephalus glaber (naked mole-rat) : Wnk1 (WNK lysine deficient protein kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04152,452,211 - 152,578,469 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,452,848 - 152,578,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,537,467 - 219,662,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44156,297,841 - 156,421,820 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14156,542,681 - 156,666,661 (-)NCBI
Celera4141,980,237 - 142,105,859 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Wnk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621141
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.