WNK1 (WNK lysine deficient protein kinase 1) - Rat Genome Database

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Gene: WNK1 (WNK lysine deficient protein kinase 1) Sus scrofa
Analyze
Symbol: WNK1
Name: WNK lysine deficient protein kinase 1
RGD ID: 14293245
Description: ENCODES a protein that exhibits ATP binding (ortholog); magnesium ion binding (ortholog); phosphatase binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to chemokine (ortholog); negative regulation of GTPase activity (ortholog); PARTICIPATES IN Erk5 MAPK signaling pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); hereditary sensory and autonomic neuropathy type 2 (ortholog); hereditary sensory and autonomic neuropathy type 2A (ortholog); FOUND IN cytoplasm (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: HSN2; LOW QUALITY PROTEIN: serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl568,001,104 - 68,140,757 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1568,000,792 - 68,142,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2570,264,470 - 70,408,519 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IBA,IEA)
membrane  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:15060842   PMID:18521183  


Genomics

Comparative Map Data
WNK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl568,001,104 - 68,140,757 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1568,000,792 - 68,142,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2570,264,470 - 70,408,519 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12752,579 - 911,452 (+)EnsemblGRCh38hg38GRCh38
GRCh3812752,579 - 911,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712861,745 - 1,020,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612732,486 - 890,879 (+)NCBINCBI36hg18NCBI36
Build 3412732,992 - 888,219NCBI
Celera122,468,382 - 2,626,915 (+)NCBI
Cytogenetic Map12p13.33NCBI
HuRef12714,669 - 871,790 (+)NCBIHuRef
CHM1_112861,230 - 1,019,755 (+)NCBICHM1_1
Wnk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,900,930 - 120,015,659 (-)NCBIGRCm39mm39
GRCm39 Ensembl6119,900,930 - 120,015,633 (-)Ensembl
GRCm386119,923,969 - 120,038,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,923,969 - 120,038,672 (-)EnsemblGRCm38mm10GRCm38
MGSCv376119,873,987 - 119,988,673 (-)NCBIGRCm37mm9NCBIm37
MGSCv366119,889,957 - 120,003,398 (-)NCBImm8
Celera6121,760,900 - 121,876,945 (-)NCBICelera
Cytogenetic Map6F1NCBI
Wnk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24153,128,334 - 153,253,905 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4153,128,334 - 153,253,905 (-)Ensembl
Rnor_6.04152,452,211 - 152,578,469 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,452,848 - 152,578,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,537,467 - 219,662,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44156,297,841 - 156,421,820 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14156,542,681 - 156,666,661 (-)NCBI
Celera4141,980,237 - 142,105,859 (-)NCBICelera
Cytogenetic Map4q42NCBI
Wnk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554546,228,492 - 6,358,637 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554546,228,492 - 6,358,690 (-)NCBIChiLan1.0ChiLan1.0
WNK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112791,153 - 945,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12791,153 - 944,602 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012825,659 - 985,016 (+)NCBIMhudiblu_PPA_v0panPan3
WNK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12742,764,184 - 42,914,591 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2742,765,181 - 42,912,806 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,768,749 - 3,918,144 (-)NCBI
ROS_Cfam_1.02743,125,909 - 43,275,644 (+)NCBI
UMICH_Zoey_3.12743,064,974 - 43,214,364 (+)NCBI
UNSW_CanFamBas_1.02743,036,519 - 43,186,218 (+)NCBI
UU_Cfam_GSD_1.0273,127,998 - 3,277,800 (-)NCBI
Wnk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945108,114,216 - 108,250,464 (-)NCBI
SpeTri2.0NW_004936606933,637 - 1,069,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111736,668 - 893,404 (+)NCBI
ChlSab1.1 Ensembl11737,590 - 890,762 (+)Ensembl
Vero_WHO_p1.0NW_0236660637,446,465 - 7,603,119 (-)NCBI
Wnk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247358,987,390 - 9,122,277 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000038423   ⟹   ENSSSCP00000042408
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl568,001,104 - 68,140,757 (+)Ensembl
RefSeq Acc Id: XM_013997884   ⟹   XP_013853338
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1568,000,792 - 68,142,533 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013853338 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS86809 (Get FASTA)   NCBI Sequence Viewer  
  Q6R2V0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013853338   ⟸   XM_013997884
- Sequence:
RefSeq Acc Id: ENSSSCP00000042408   ⟸   ENSSSCT00000038423
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000753 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00040074009 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000042408 UniProtKB/TrEMBL
  ENSSSCP00040046393 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000038423 UniProtKB/TrEMBL
  ENSSSCT00040102601 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene WNK1 ENTREZGENE
Pfam OSR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AEZ4_PIG UniProtKB/TrEMBL
  Q6R2V0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F1SHS6 UniProtKB/Swiss-Prot
VGNC ID VGNC:94962 ENTREZGENE