Pacsin1 (protein kinase C and casein kinase substrate in neurons 1) - Rat Genome Database

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Gene: Pacsin1 (protein kinase C and casein kinase substrate in neurons 1) Rattus norvegicus
Analyze
Symbol: Pacsin1
Name: protein kinase C and casein kinase substrate in neurons 1
RGD ID: 3247
Description: Enables phospholipid binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of dendrite development; and regulation of postsynaptic neurotransmitter receptor internalization. Located in axon terminus; perinuclear region of cytoplasm; and plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human PACSIN1 (protein kinase C and casein kinase substrate in neurons 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dynamin PRD-interacting protein; dynamin proline-rich domain-interacting protein; protein kinase C and casein kinase substrate in neurons protein 1; sdpI; synaptic, dynamin-associated protein I; syndapin 1; syndapin I; syndapin-1; syndapin-I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,719,929 - 5,769,492 (+)NCBIGRCr8
mRatBN7.2205,718,134 - 5,768,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,719,857 - 5,765,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,432,443 - 6,477,979 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,794,221 - 5,839,766 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,273,992 - 6,319,361 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,241,248 - 7,286,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,279,820 - 7,286,586 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,443,609 - 9,489,048 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,875,450 - 5,921,738 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,875,676 - 5,921,965 (+)NCBI
Celera207,282,963 - 7,327,615 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cordon-bleu is an actin nucleation factor and controls neuronal morphology. Ahuja R, etal., Cell. 2007 Oct 19;131(2):337-50.
2. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Anggono V, etal., Nat Neurosci. 2006 Jun;9(6):752-60. doi: 10.1038/nn1695. Epub 2006 Apr 30.
4. PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Anggono V, etal., Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13976-81. doi: 10.1073/pnas.1312467110. Epub 2013 Aug 5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Hou W, etal., PLoS Biol. 2015 Sep 3;13(9):e1002233. doi: 10.1371/journal.pbio.1002233. eCollection 2015.
8. Syndapins integrate N-WASP in receptor-mediated endocytosis. Kessels MM and Qualmann B, EMBO J 2002 Nov 15;21(22):6083-94.
9. Interaction of SPIN90 with syndapin is implicated in clathrin-mediated endocytic pathway in fibroblasts. Kim SH, etal., Genes Cells. 2006 Oct;11(10):1197-211.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Pérez-Otaño I, etal., Nat Neurosci. 2006 May;9(5):611-21. doi: 10.1038/nn1680. Epub 2006 Apr 16.
13. Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein. Qualmann B, etal., Mol Biol Cell 1999 Feb;10(2):501-13.
14. Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Quan A, etal., Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3760-5. doi: 10.1073/pnas.1108294109. Epub 2012 Feb 21.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The functions of the actin nucleator Cobl in cellular morphogenesis critically depend on syndapin I. Schwintzer L, etal., EMBO J. 2011 Jul 1;30(15):3147-59. doi: 10.1038/emboj.2011.207.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton. Wasiak S, etal., J Biol Chem 2001 Jul 13;276(28):26622-8.
21. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
22. Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1. Zucconi A, etal., J Mol Biol. 2001 Apr 13;307(5):1329-39.
Additional References at PubMed
PMID:9746365   PMID:11082044   PMID:15865439   PMID:15930129   PMID:16540475   PMID:17634366   PMID:19101610   PMID:19549836   PMID:20404169   PMID:21640082   PMID:21926968   PMID:22871113  
PMID:23785143   PMID:24509844   PMID:27488904   PMID:28235806   PMID:34290082  


Genomics

Comparative Map Data
Pacsin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,719,929 - 5,769,492 (+)NCBIGRCr8
mRatBN7.2205,718,134 - 5,768,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,719,857 - 5,765,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,432,443 - 6,477,979 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,794,221 - 5,839,766 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,273,992 - 6,319,361 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,241,248 - 7,286,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,279,820 - 7,286,586 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,443,609 - 9,489,048 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,875,450 - 5,921,738 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,875,676 - 5,921,965 (+)NCBI
Celera207,282,963 - 7,327,615 (+)NCBICelera
Cytogenetic Map20p12NCBI
PACSIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38634,466,076 - 34,535,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl634,466,061 - 34,535,229 (+)EnsemblGRCh38hg38GRCh38
GRCh37634,433,853 - 34,503,000 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36634,541,883 - 34,610,978 (+)NCBINCBI36Build 36hg18NCBI36
Build 34634,541,882 - 34,610,976NCBI
Celera635,988,242 - 36,057,336 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef634,156,470 - 34,225,623 (+)NCBIHuRef
CHM1_1634,436,833 - 34,505,990 (+)NCBICHM1_1
T2T-CHM13v2.0634,289,922 - 34,359,072 (+)NCBIT2T-CHM13v2.0
Pacsin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,874,565 - 27,930,092 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,874,483 - 27,930,456 (+)EnsemblGRCm39 Ensembl
GRCm381727,655,591 - 27,711,118 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,655,509 - 27,711,482 (+)EnsemblGRCm38mm10GRCm38
MGSCv371727,792,627 - 27,848,051 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361727,383,271 - 27,438,695 (+)NCBIMGSCv36mm8
Celera1728,208,328 - 28,262,887 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.59NCBI
Pacsin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,634,056 - 2,666,098 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,621,013 - 2,665,194 (+)NCBIChiLan1.0ChiLan1.0
PACSIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,936,406 - 49,005,653 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1644,803,788 - 44,873,037 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0634,030,769 - 34,100,029 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1635,131,697 - 35,201,440 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl635,180,099 - 35,201,440 (+)Ensemblpanpan1.1panPan2
PACSIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,754,075 - 3,811,717 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,753,717 - 3,809,986 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha123,769,517 - 3,827,580 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,090,836 - 4,148,898 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,090,725 - 4,148,893 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,752,394 - 3,810,382 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,833,730 - 3,891,767 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,932,863 - 3,990,934 (+)NCBIUU_Cfam_GSD_1.0
Pacsin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494639,337,736 - 39,386,124 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647624,571,877 - 24,622,707 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647624,574,106 - 24,622,494 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PACSIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl730,492,589 - 30,512,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1730,459,851 - 30,512,736 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2735,237,179 - 35,244,167 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PACSIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11737,565,059 - 37,630,637 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1737,563,714 - 37,574,063 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604434,389,671 - 34,457,426 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pacsin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475422,723,317 - 22,734,344 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475422,723,479 - 22,762,262 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pacsin1
329 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:23
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000037772
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
RH138881  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,765,108 - 5,765,235 (+)MAPPERmRatBN7.2
Rnor_6.0207,286,498 - 7,286,624NCBIRnor6.0
Rnor_5.0209,488,844 - 9,488,970UniSTSRnor5.0
RGSC_v3.4205,921,534 - 5,921,660UniSTSRGSC3.4
Celera207,327,411 - 7,327,537UniSTS
RH 3.4 Map2057.54UniSTS
Cytogenetic Map20p12UniSTS
AA858870  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,767,530 - 5,767,669 (+)MAPPERmRatBN7.2
Rnor_6.0207,288,920 - 7,289,058NCBIRnor6.0
Rnor_5.0209,491,266 - 9,491,404UniSTSRnor5.0
RGSC_v3.4205,923,956 - 5,924,094UniSTSRGSC3.4
Celera207,329,833 - 7,329,971UniSTS
RH 3.4 Map2071.9UniSTS
Cytogenetic Map20p12UniSTS
BE095567  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,767,873 - 5,768,026 (+)MAPPERmRatBN7.2
Rnor_6.0207,289,263 - 7,289,415NCBIRnor6.0
Rnor_5.0209,491,609 - 9,491,761UniSTSRnor5.0
RGSC_v3.4205,924,299 - 5,924,451UniSTSRGSC3.4
Celera207,330,176 - 7,330,328UniSTS
RH 3.4 Map2059.1UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000090820   ⟹   ENSRNOP00000069980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,719,857 - 5,765,313 (+)Ensembl
Rnor_6.0 Ensembl207,279,820 - 7,286,586 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094726   ⟹   ENSRNOP00000089554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,759,888 - 5,765,313 (+)Ensembl
RefSeq Acc Id: NM_017294   ⟹   NP_058990
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,721,660 - 5,767,109 (+)NCBI
mRatBN7.2205,719,857 - 5,765,313 (+)NCBI
Rnor_6.0207,241,248 - 7,286,702 (+)NCBI
Rnor_5.0209,443,609 - 9,489,048 (+)NCBI
RGSC_v3.4205,875,450 - 5,921,738 (+)RGD
Celera207,282,963 - 7,327,615 (+)RGD
Sequence:
RefSeq Acc Id: XM_039098628   ⟹   XP_038954556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,750,664 - 5,769,492 (+)NCBI
mRatBN7.2205,748,864 - 5,768,064 (+)NCBI
RefSeq Acc Id: XM_039098629   ⟹   XP_038954557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,719,929 - 5,769,492 (+)NCBI
mRatBN7.2205,718,134 - 5,768,064 (+)NCBI
RefSeq Acc Id: NP_058990   ⟸   NM_017294
- UniProtKB: Q9Z0W5 (UniProtKB/Swiss-Prot),   A0A0G2JWR2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069980   ⟸   ENSRNOT00000090820
RefSeq Acc Id: XP_038954557   ⟸   XM_039098629
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954556   ⟸   XM_039098628
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWR2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089554   ⟸   ENSRNOT00000094726
Protein Domains
F-BAR   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0W5-F1-model_v2 AlphaFold Q9Z0W5 1-441 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3247 AgrOrtholog
BioCyc Gene G2FUF-4462 BioCyc
Ensembl Genes ENSRNOG00000054603 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00065024677 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090820.2 UniProtKB/TrEMBL
  ENSRNOT00000094726.1 UniProtKB/TrEMBL
  ENSRNOT00065042381 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FCH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PACSIN1/PACSIN2_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PACSIN1_F-BAR UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29704 UniProtKB/Swiss-Prot
NCBI Gene 29704 ENTREZGENE
PANTHER PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23065:SF16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pacsin1 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054603 RatGTEx
  ENSRNOG00065024677 RatGTEx
SMART FCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220296
UniProt A0A0G2JWR2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7J3_RAT UniProtKB/TrEMBL
  A6JJM9_RAT UniProtKB/TrEMBL
  PACN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pacsin1  protein kinase C and casein kinase substrate in neurons 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with dynamin I, synaptojanin, and synapsin I; interaction occurs via the pacsin 1 src homology 3 (SH3) domain 69919
gene_physical_interaction binds mSos by interacting with the mSos1 proline-rich domain 68674
gene_physical_interaction binds mSos by interacting with the mSos1 proline-rich domain 69919
gene_process functions in endocytosis and regulation of actin dynamics 68674
gene_process functions in endocytosis and regulation of actin dynamics 69919
gene_process may function with Sos1 in regulation of actin dynamics 68674
gene_process may function with Sos1 in regulation of actin dynamics 69919