Hdc (histidine decarboxylase) - Rat Genome Database

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Gene: Hdc (histidine decarboxylase) Rattus norvegicus
Analyze
Symbol: Hdc
Name: histidine decarboxylase
RGD ID: 2790
Description: Enables several functions, including histidine decarboxylase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Involved in L-histidine metabolic process and histamine metabolic process. Located in dendrite and neuronal cell body. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,5'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC156577
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,300,628 - 134,318,704 (-)NCBIGRCr8
mRatBN7.23113,847,256 - 113,865,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,847,260 - 113,865,341 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,730,587 - 117,748,889 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,326,119 - 126,344,421 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,986,497 - 124,004,800 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,057,524 - 119,075,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,057,517 - 119,075,619 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,585,190 - 125,603,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,119,316 - 114,138,107 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,024,891 - 114,043,687 (-)NCBI
Celera3112,689,823 - 112,707,916 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,5'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
alachlor  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-methylhistamine  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Atractylone  (ISO)
B 823-08  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
Calcimycin  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dichlorvos  (EXP)
diethylstilbestrol  (EXP,ISO)
diiodine  (ISO)
diisopropyl fluorophosphate  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
fructose  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (EXP)
histamine  (EXP,ISO)
indole-3-methanol  (EXP)
L-ethionine  (EXP)
L-histidine  (ISO)
L-Histidine methyl ester  (ISO)
lead diacetate  (EXP,ISO)
LY294002  (ISO)
malathion  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
milnacipran  (ISO)
Mipafox  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nilotinib  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (EXP)
Pentagastrin  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrethrins  (EXP)
pyridoxal 5'-phosphate  (ISO)
quercetin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (ISO)
succimer  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Chlamydophila (Chlamydia) pneumoniae induces histidine decarboxylase production in the mouse lung. Burian K, etal., Immunol Lett. 2003 Oct 31;89(2-3):229-36.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Variability of the L-Histidine decarboxylase gene in allergic rhinitis. Gervasini G, etal., Allergy. 2010 Dec;65(12):1576-84. doi: 10.1111/j.1398-9995.2010.02425.x.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Correlation between serum gastrin concentration and rat stomach histidine decarboxylase activity. Hakanson R, etal., J Physiol. 1974 Dec;243(2):483-98.
6. Histidine decarboxylase-mediated histamine synthesis in glomeruli from rat kidneys. Heald JI and Hollis TM, Am J Physiol. 1976 May;230(5):1349-53.
7. Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. Joseph DR, etal., Proc Natl Acad Sci U S A 1990 Jan;87(2):733-7.
8. Increase in the level of histidine decarboxylase mRNA expression in nasal mucosa of rats sensitized by toluene diisocyanate. Kitamura Y, etal., Inflamm Res. 2004 Mar;53 Suppl 1:S13-4. Epub 2004 Mar 5.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. NO_AUTHOR Proc Natl Acad Sci U S A 1990 Sep;87(18):7346.
11. Spectroscopic analysis of recombinant rat histidine decarboxylase. Olmo MT, etal., J Biochem. 2002 Sep;132(3):433-9.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability. Rodriguez-Caso C, etal., Eur J Biochem. 2003 Nov;270(21):4376-87.
20. Properties of histidine decarboxylase from rat gastric mucosa. Savany A and Cronenberger L, Eur J Biochem. 1982 Apr;123(3):593-9.
21. Intracellular localization of the 74- and 53-kDa forms of L-histidine decarboxylase in a rat basophilic/mast cell line, RBL-2H3. Tanaka S, etal., J Biol Chem. 1998 Apr 3;273(14):8177-82.
22. Innervation of histaminergic neurons in the posterior hypothalamic region by medial preoptic neurons. Anterograde tracing with Phaseolus vulgaris leucoagglutinin combined with immunocytochemistry of histidine decarboxylase in the rat. Wouterlood FG and Gaykema RP, Brain Res. 1988 Jul 5;455(1):170-6.
23. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Xu X, etal., J Exp Med. 2006 Dec 25;203(13):2907-17. Epub 2006 Dec 11.
Additional References at PubMed
PMID:1702422   PMID:11478947   PMID:12414789   PMID:12477932   PMID:12763636   PMID:14961766   PMID:15316670   PMID:18310073   PMID:21440039   PMID:22767596   PMID:27997552  


Genomics

Comparative Map Data
Hdc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,300,628 - 134,318,704 (-)NCBIGRCr8
mRatBN7.23113,847,256 - 113,865,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,847,260 - 113,865,341 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,730,587 - 117,748,889 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,326,119 - 126,344,421 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,986,497 - 124,004,800 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,057,524 - 119,075,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,057,517 - 119,075,619 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,585,190 - 125,603,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,119,316 - 114,138,107 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,024,891 - 114,043,687 (-)NCBI
Celera3112,689,823 - 112,707,916 (-)NCBICelera
Cytogenetic Map3q36NCBI
HDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381550,241,947 - 50,265,726 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1550,241,947 - 50,265,965 (-)EnsemblGRCh38hg38GRCh38
GRCh371550,534,144 - 50,557,923 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361548,321,436 - 48,345,218 (-)NCBINCBI36Build 36hg18NCBI36
Build 341548,321,442 - 48,345,214NCBI
Celera1527,426,734 - 27,450,752 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1527,365,086 - 27,389,097 (-)NCBIHuRef
CHM1_11550,652,084 - 50,676,103 (-)NCBICHM1_1
T2T-CHM13v2.01548,050,179 - 48,073,964 (-)NCBIT2T-CHM13v2.0
Hdc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,435,579 - 126,465,942 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,435,587 - 126,461,219 (-)EnsemblGRCm39 Ensembl
GRCm382126,593,659 - 126,624,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,593,667 - 126,619,299 (-)EnsemblGRCm38mm10GRCm38
MGSCv372126,419,404 - 126,444,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,285,109 - 126,310,106 (-)NCBIMGSCv36mm8
Celera2127,832,271 - 127,857,347 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Hdc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554094,051,271 - 4,072,642 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554094,051,574 - 4,072,641 (+)NCBIChiLan1.0ChiLan1.0
HDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21639,480,087 - 39,504,191 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11543,664,223 - 43,688,339 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01529,188,296 - 29,212,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11547,510,629 - 47,534,577 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1547,510,629 - 47,534,577 (-)Ensemblpanpan1.1panPan2
HDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,201,222 - 16,223,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,127,350 - 16,149,277 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03016,345,121 - 16,367,075 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3016,345,127 - 16,367,248 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13016,267,658 - 16,289,600 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03016,385,120 - 16,407,243 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03016,491,552 - 16,513,689 (-)NCBIUU_Cfam_GSD_1.0
Hdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864094,455,739 - 94,476,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647112,304,130 - 12,324,570 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647112,303,802 - 12,324,613 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,505,751 - 121,525,252 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,505,677 - 121,525,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,147,966 - 135,167,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12633,051,048 - 33,074,872 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2633,051,966 - 33,074,563 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048108,074,673 - 108,095,456 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247319,835,596 - 9,856,743 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,835,585 - 9,856,743 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hdc
229 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:30
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000041569
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH128172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23113,847,371 - 113,847,563 (+)MAPPERmRatBN7.2
Rnor_6.03119,057,640 - 119,057,831NCBIRnor6.0
Rnor_5.03125,585,306 - 125,585,497UniSTSRnor5.0
RGSC_v3.43114,119,432 - 114,119,623UniSTSRGSC3.4
Celera3112,689,939 - 112,690,130UniSTS
RH 3.4 Map3988.2UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 48 113 91 90 59 25 59 6 217 96 93 45 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000041569   ⟹   ENSRNOP00000041885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3113,847,260 - 113,865,341 (-)Ensembl
Rnor_6.0 Ensembl3119,057,528 - 119,075,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086724   ⟹   ENSRNOP00000072167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3113,847,260 - 113,864,222 (-)Ensembl
Rnor_6.0 Ensembl3119,057,517 - 119,075,619 (-)Ensembl
RefSeq Acc Id: NM_017016   ⟹   NP_058712
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,300,628 - 134,318,704 (-)NCBI
mRatBN7.23113,847,256 - 113,865,334 (-)NCBI
Rnor_6.03119,057,524 - 119,075,599 (-)NCBI
Rnor_5.03125,585,190 - 125,603,276 (-)NCBI
RGSC_v3.43114,119,316 - 114,138,107 (-)RGD
Celera3112,689,823 - 112,707,916 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058712 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41326 (Get FASTA)   NCBI Sequence Viewer  
  AAI28725 (Get FASTA)   NCBI Sequence Viewer  
  EDL80088 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041885.5
  ENSRNOP00000072167.2
GenBank Protein P16453 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058712   ⟸   NM_017016
- UniProtKB: Q63029 (UniProtKB/Swiss-Prot),   P16453 (UniProtKB/Swiss-Prot),   A1A5M4 (UniProtKB/TrEMBL),   D3ZMT4 (UniProtKB/TrEMBL),   A0A9K3Y711 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041885   ⟸   ENSRNOT00000041569
Ensembl Acc Id: ENSRNOP00000072167   ⟸   ENSRNOT00000086724

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16453-F1-model_v2 AlphaFold P16453 1-656 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692389
Promoter ID:EPDNEW_R2914
Type:single initiation site
Name:Hdc_1
Description:histidine decarboxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03119,075,618 - 119,075,678EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2790 AgrOrtholog
BioCyc Gene G2FUF-48023 BioCyc
BioCyc Pathway PWY-6173 [histamine biosynthesis] BioCyc
BioCyc Pathway Image PWY-6173 BioCyc
Ensembl Genes ENSRNOG00000010262 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041569.5 UniProtKB/TrEMBL
  ENSRNOT00000086724.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dopa decarboxylase, N-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8375507 IMAGE-MGC_LOAD
InterPro Aromatic_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyridoxal-P_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24443 UniProtKB/TrEMBL
MGC_CLONE MGC:156577 IMAGE-MGC_LOAD
NCBI Gene 24443 ENTREZGENE
PANTHER GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTIDINE DECARBOXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hdc PhenoGen
PRINTS YHDCRBOXLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DDC_GAD_HDC_YDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010262 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2A8_RAT UniProtKB/TrEMBL
  A0A9K3Y711 ENTREZGENE, UniProtKB/TrEMBL
  A1A5M4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMT4 ENTREZGENE
  DCHS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63029 ENTREZGENE
UniProt Secondary D3ZMT4 UniProtKB/TrEMBL
  Q63029 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hdc  Histidine decarboxylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 655 amino acid residues with an Mr of 73,450 632903