HDC (histidine decarboxylase) - Rat Genome Database

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Gene: HDC (histidine decarboxylase) Canis lupus familiaris
Analyze
Symbol: HDC
Name: histidine decarboxylase
RGD ID: 12364211
Description: ENCODES a protein that exhibits amino acid binding (ortholog); histidine decarboxylase activity (ortholog); identical protein binding (ortholog); INVOLVED IN histamine biosynthetic process (ortholog); histamine metabolic process (ortholog); histidine catabolic process (ortholog); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; ASSOCIATED WITH asthma (ortholog); Bloom syndrome (ortholog); Chlamydophila Infections (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,201,222 - 16,223,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,127,350 - 16,149,277 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03016,345,121 - 16,367,075 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3016,345,127 - 16,367,248 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13016,267,658 - 16,289,600 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03016,385,120 - 16,407,243 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03016,491,552 - 16,513,689 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,201,222 - 16,223,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,127,350 - 16,149,277 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03016,345,121 - 16,367,075 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3016,345,127 - 16,367,248 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13016,267,658 - 16,289,600 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03016,385,120 - 16,407,243 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03016,491,552 - 16,513,689 (-)NCBIUU_Cfam_GSD_1.0
HDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381550,241,947 - 50,265,726 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1550,241,947 - 50,265,965 (-)EnsemblGRCh38hg38GRCh38
GRCh371550,534,144 - 50,557,923 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361548,321,436 - 48,345,218 (-)NCBINCBI36Build 36hg18NCBI36
Build 341548,321,442 - 48,345,214NCBI
Celera1527,426,734 - 27,450,752 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1527,365,086 - 27,389,097 (-)NCBIHuRef
CHM1_11550,652,084 - 50,676,103 (-)NCBICHM1_1
T2T-CHM13v2.01548,050,179 - 48,073,964 (-)NCBIT2T-CHM13v2.0
Hdc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,435,579 - 126,465,942 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,435,587 - 126,461,219 (-)EnsemblGRCm39 Ensembl
GRCm382126,593,659 - 126,624,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,593,667 - 126,619,299 (-)EnsemblGRCm38mm10GRCm38
MGSCv372126,419,404 - 126,444,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,285,109 - 126,310,106 (-)NCBIMGSCv36mm8
Celera2127,832,271 - 127,857,347 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Hdc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,300,628 - 134,318,704 (-)NCBIGRCr8
mRatBN7.23113,847,256 - 113,865,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3113,847,260 - 113,865,341 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3117,730,587 - 117,748,889 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,326,119 - 126,344,421 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03123,986,497 - 124,004,800 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,057,524 - 119,075,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,057,517 - 119,075,619 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,585,190 - 125,603,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,119,316 - 114,138,107 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,024,891 - 114,043,687 (-)NCBI
Celera3112,689,823 - 112,707,916 (-)NCBICelera
Cytogenetic Map3q36NCBI
Hdc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554094,051,271 - 4,072,642 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554094,051,574 - 4,072,641 (+)NCBIChiLan1.0ChiLan1.0
HDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21639,480,087 - 39,504,191 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11543,664,223 - 43,688,339 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01529,188,296 - 29,212,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11547,510,629 - 47,534,577 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1547,510,629 - 47,534,577 (-)Ensemblpanpan1.1panPan2
Hdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864094,455,739 - 94,476,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647112,304,130 - 12,324,570 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647112,303,802 - 12,324,613 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,505,751 - 121,525,252 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,505,677 - 121,525,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,147,966 - 135,167,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12633,051,048 - 33,074,872 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2633,051,966 - 33,074,563 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048108,074,673 - 108,095,456 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247319,835,596 - 9,856,743 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,835,585 - 9,856,743 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HDC
177 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 11 2 3 2 6 4 10 1
Low 4 5 11 4 3 4 6 8 8 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023936   ⟹   ENSCAFP00000022221
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070959   ⟹   ENSCAFP00000053891
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041423   ⟹   ENSCAFP00845032480
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3016,345,127 - 16,367,248 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041523   ⟹   ENSCAFP00845032553
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3016,345,127 - 16,367,248 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041585   ⟹   ENSCAFP00845032606
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3016,345,127 - 16,367,248 (-)Ensembl
RefSeq Acc Id: XM_038442307   ⟹   XP_038298235
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03016,345,121 - 16,367,075 (-)NCBI
RefSeq Acc Id: XM_038516754   ⟹   XP_038372682
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13016,267,658 - 16,289,600 (-)NCBI
RefSeq Acc Id: XM_038580394   ⟹   XP_038436322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03016,491,552 - 16,513,689 (-)NCBI
RefSeq Acc Id: XM_038644687   ⟹   XP_038500615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03016,385,120 - 16,407,243 (-)NCBI
RefSeq Acc Id: XM_544676   ⟹   XP_544676
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,201,222 - 16,223,452 (-)NCBI
Dog10K_Boxer_Tasha3016,127,350 - 16,149,277 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_544676   ⟸   XM_544676
- UniProtKB: A0A8C0T5X1 (UniProtKB/TrEMBL),   A0A8I3PM83 (UniProtKB/TrEMBL),   A0A8C0Z2J6 (UniProtKB/TrEMBL),   A0A8I3PEM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053891   ⟸   ENSCAFT00000070959
RefSeq Acc Id: ENSCAFP00000022221   ⟸   ENSCAFT00000023936
RefSeq Acc Id: XP_038372682   ⟸   XM_038516754
RefSeq Acc Id: XP_038500615   ⟸   XM_038644687
RefSeq Acc Id: XP_038298235   ⟸   XM_038442307
- UniProtKB: A0A8C0T5X1 (UniProtKB/TrEMBL),   A0A8I3PM83 (UniProtKB/TrEMBL),   A0A8C0Z2J6 (UniProtKB/TrEMBL),   A0A8I3PEM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038436322   ⟸   XM_038580394
- UniProtKB: A0A8C0PIZ2 (UniProtKB/TrEMBL),   A0A8C0Q008 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845032553   ⟸   ENSCAFT00845041523
RefSeq Acc Id: ENSCAFP00845032606   ⟸   ENSCAFT00845041585
RefSeq Acc Id: ENSCAFP00845032480   ⟸   ENSCAFT00845041423


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015072 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030026234 UniProtKB/TrEMBL
  ENSCAFG00040019823 UniProtKB/TrEMBL
  ENSCAFG00845023453 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023936.5 UniProtKB/TrEMBL
  ENSCAFT00000070959.2 UniProtKB/TrEMBL
  ENSCAFT00000097852.1 UniProtKB/TrEMBL
  ENSCAFT00030048555.1 UniProtKB/TrEMBL
  ENSCAFT00030048557.1 UniProtKB/TrEMBL
  ENSCAFT00040036926.1 UniProtKB/TrEMBL
  ENSCAFT00040036942.1 UniProtKB/TrEMBL
  ENSCAFT00845041423 ENTREZGENE
  ENSCAFT00845041423.1 UniProtKB/TrEMBL
  ENSCAFT00845041523.1 UniProtKB/TrEMBL
  ENSCAFT00845041585.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
  dopa decarboxylase, N-terminal domain UniProtKB/TrEMBL
InterPro Aromatic_deC UniProtKB/TrEMBL
  PyrdxlP-dep_de-COase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
  Pyridoxal-P_BS UniProtKB/TrEMBL
KEGG Report cfa:487551 UniProtKB/TrEMBL
NCBI Gene HDC ENTREZGENE
PANTHER GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE UniProtKB/TrEMBL
  HISTIDINE DECARBOXYLASE UniProtKB/TrEMBL
Pfam Pyridoxal_deC UniProtKB/TrEMBL
PRINTS YHDCRBOXLASE UniProtKB/TrEMBL
PROSITE DDC_GAD_HDC_YDC UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
UniProt A0A8C0PIZ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q008 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T5X1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z2J6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PEM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PM83 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S3Q4_CANLF UniProtKB/TrEMBL
  A0A8P0PR04_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41625 ENTREZGENE