HDC (histidine decarboxylase) - Rat Genome Database
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Gene: HDC (histidine decarboxylase) Canis lupus familiaris
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Symbol: HDC
Name: histidine decarboxylase
RGD ID: 12364211
Description: ENCODES a protein that exhibits amino acid binding (ortholog); identical protein binding (ortholog); INVOLVED IN histamine metabolic process (ortholog); histidine metabolic process (ortholog); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; ASSOCIATED WITH asthma (ortholog); Chlamydophila Infections (ortholog); Gilles de la Tourette syndrome (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13016,201,222 - 16,223,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
HDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13016,201,222 - 16,223,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
HDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1550,241,947 - 50,265,965 (-)EnsemblGRCh38hg38GRCh38
GRCh381550,241,945 - 50,266,049 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371550,534,144 - 50,558,162 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361548,321,436 - 48,345,218 (-)NCBINCBI36hg18NCBI36
Build 341548,321,442 - 48,345,214NCBI
Celera1527,426,734 - 27,450,752 (-)NCBI
Cytogenetic Map15q21.2NCBI
HuRef1527,365,086 - 27,389,097 (-)NCBIHuRef
CHM1_11550,652,084 - 50,676,103 (-)NCBICHM1_1
Hdc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,435,579 - 126,465,942 (-)NCBIGRCm39mm39
GRCm382126,593,659 - 126,624,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,593,667 - 126,619,299 (-)EnsemblGRCm38mm10GRCm38
MGSCv372126,419,404 - 126,444,401 (-)NCBIGRCm37mm9NCBIm37
MGSCv362126,285,109 - 126,310,106 (-)NCBImm8
Celera2127,832,271 - 127,857,347 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Hdc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03119,057,524 - 119,075,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,057,517 - 119,075,619 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,585,190 - 125,603,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,119,316 - 114,138,107 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13114,024,891 - 114,043,687 (-)NCBI
Celera3112,689,823 - 112,707,916 (-)NCBICelera
Cytogenetic Map3q36NCBI
Hdc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554094,051,271 - 4,072,642 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554094,051,574 - 4,072,641 (+)NCBIChiLan1.0ChiLan1.0
HDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11547,510,629 - 47,534,577 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1547,510,629 - 47,534,577 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01529,188,296 - 29,212,327 (-)NCBIMhudiblu_PPA_v0panPan3
Hdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647112,303,802 - 12,324,613 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,505,742 - 121,525,255 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,505,677 - 121,525,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21135,147,966 - 135,167,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HDC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2633,051,966 - 33,074,563 (+)Ensembl
ChlSab1.12633,051,048 - 33,074,872 (+)NCBI
Hdc
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247319,835,585 - 9,856,743 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 11 2 3 2 6 4 10 1
Low 4 5 11 4 3 4 6 8 8 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_544676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX03016119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000023936   ⟹   ENSCAFP00000022221
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070959   ⟹   ENSCAFP00000053891
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3016,201,589 - 16,223,662 (-)Ensembl
RefSeq Acc Id: XM_544676   ⟹   XP_544676
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13016,201,222 - 16,223,452 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_544676 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_544676   ⟸   XM_544676
- UniProtKB: E2RMU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053891   ⟸   ENSCAFT00000070959
RefSeq Acc Id: ENSCAFP00000022221   ⟸   ENSCAFT00000023936


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015072 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000022221 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000053891 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023936 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000070959 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aromatic_deC UniProtKB/TrEMBL
  PyrdxlP-dep_de-COase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub1 UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major_sub2 UniProtKB/TrEMBL
  Pyridoxal-P_BS UniProtKB/TrEMBL
KEGG Report cfa:487551 UniProtKB/TrEMBL
NCBI Gene HDC ENTREZGENE
Pfam Pyridoxal_deC UniProtKB/TrEMBL
PRINTS YHDCRBOXLASE UniProtKB/TrEMBL
PROSITE DDC_GAD_HDC_YDC UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
UniProt A0A5F4CKH0_CANLF UniProtKB/TrEMBL
  E2RMU1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41625 ENTREZGENE