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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2790
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdc
Name: histidine decarboxylase
Acc ID: CHEBI:18405
Term: pyridoxal 5'-phosphate
Definition: The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Chemical ID: MESH:D011732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdcaffects bindingISOHDC (Homo sapiens)6480464CTDChlorpyrifos binds to [HDC protein binds to Pyridoxal Phosphate]; Diazinon binds to [HDC protein binds to Pyridoxal Phosphate]; Glyphosate binds to [HDC protein binds to Pyridoxal Phosphate]; HDC protein binds to Pyridoxal Phosphate; Isoflurophate binds to [HDC protein binds to Pyridoxal Phosphate]; Malathion binds to [HDC protein binds to Pyridoxal Phosphate]; mipafox binds to [HDC protein binds to Pyridoxal Phosphate]; novichok binds to [HDC protein binds to Pyridoxal Phosphate]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate binds to [HDC protein binds to Pyridoxal Phosphate]; Paraoxon binds to [HDC protein binds to Pyridoxal Phosphate]; phenyl di-n-pentylphosphinate binds to [HDC protein binds to Pyridoxal Phosphate]; phenylsaligenin cyclic phosphate binds to [HDC protein binds to Pyridoxal Phosphate]; S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate binds to [HDC protein binds to Pyridoxal Phosphate]; Sarin binds to [HDC protein binds to Pyridoxal Phosphate]; Soman binds to [HDC protein binds to Pyridoxal Phosphate]; tabun binds to [HDC protein binds to Pyridoxal Phosphate]; VX binds to [HDC protein binds to Pyridoxal Phosphate]PMID:35151785
Hdcmultiple interactionsISOHDC (Homo sapiens)6480464CTD[HDC protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of HistidinePMID:35151785
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